| Name | P glycoprotein |
|---|---|
| Synonyms | ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16956706 | Dinis-Oliveira RJ, Duarte JA, Remiao F, Sanchez-Navarro A, Bastos ML, Carvalho F: Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats. Toxicology. 2006 Oct 3;227(1-2):73-85. Epub 2006 Aug 3. Dexamethasone (DEX), a synthetic corticosteroid, has been successfully used in clinical practice during paraquat (PQ) poisonings due to its anti-inflammatory activity, although, as recently observed, its effects related to de novo synthesis of P-glycoprotein (P-gp), may also strongly contribute for its healing effects. |
82(1,1,1,2) | Details |
| 17015168 | Dinis-Oliveira RJ, Remiao F, Duarte JA, Ferreira R, Sanchez Navarro A, Bastos ML, Carvalho F: P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity. Free Radic Biol Med. 2006 Oct 15;41(8):1213-24. Epub 2006 Jul 3. |
9(0,0,1,4) | Details |
| 11557130 | Lehmann T, Kohler C, Weidauer E, Taege C, Foth H: Expression of MRP1 and related transporters in human lung cells in culture. Toxicology. 2001 Oct 5;167(1):59-72. Multidrug resistance type 1 P-glycoproteins (P-gp) and multidrug resistance associated proteins (MRP) were studied in differentiated primary human lung cells in culture, in comparison with permanent human lung cell lines and primary alveolar type II cells from rat lung. AII cells exhibited low basal levels of mdr1b mRNA, that increased over time and after radical production induced by paraquat. mRNAs coding for antioxidative enzymes catalase (CAT), maganese superoxide dismutase (Mn-SOD) and /zinc superoxide dismutase (Cu/Zn-SOD) were not changed. |
3(0,0,0,3) | Details |
| 11178967 | Kim HS, Lee TB, Choi CH: Down-regulation of catalase gene expression in the doxorubicin-resistant AML subline AML-2/DX100. Biochem Biophys Res Commun. 2001 Feb 16;281(1):109-14. The AML-2/DX100 also showed various levels of resistance to daunorubicin and vincristine but was paradoxically sensitive to peroxide (5-fold), t-butyl hydroperoxide (3-fold), and paraquat (2-fold) when compared to the drug-sensitive parental AML-2 cells (AML-2/WT). |
0(0,0,0,0) | Details |