Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
20050821 Gil HW, Seok SJ, Jeong DS, Yang JO, Lee EY, Hong SY: Plasma level of malondialdehyde in the cases of acute paraquat intoxication. Clin Toxicol. 2010 Feb;48(2):149-52.

However, the following parameters were significantly different between survivors and nonsurvivors: the amount of PQ ingestion, plasma PQ levels, basal MDA levels, WBC, hemoglobin, hematocrit, platelet counts, albumin, BUN, creatinine, potassium, amylase, and arterial blood gas analysis (pH, pCO (2), HCO (-)(3)).The nonsurvivors' baseline MDA (11.4 +/- 3.8 vs. 9.8 +/- 2.8, p = 0.040) was higher than the survivors.
1(0,0,0,1) Details
10492276 Kao CH, Hsieh JF, Ho YJ, Hung DZ, Lin TJ, Ding HJ: Acute paraquat intoxication: using nuclear pulmonary studies to predict patient outcome. Chest. 1999 Sep;116(3):709-14.

MEASUREMENTS AND RESULTS: 99mTc DTPA aerosol inhalation and 99mTc macroaggregated albumin (MAA) perfusion lung scintigraphies were performed to determine LV, AP, and lung perfusion (LP).
1(0,0,0,1) Details
12167315 Jaiswal R, Khan MA, Musarrat J: Photosensitized paraquat-induced structural alterations and free radical mediated fragmentation of serum albumin. J Photochem Photobiol B. 2002 Jul;67(3):163-70.

The binding constants (K (a)) and binding capacity (n) of albumin for paraquat were determined to be 3.4 x 10 (5) l/mole and 12.9, respectively.
255(3,3,5,5) Details
18344105 Hantson P, Bernard A, Hermans C: Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury. Clin Toxicol. 2008 Mar;46(3):230-8.

METHODS: Rats were treated with 4-Ipomeanol (IPO), alpha-naphtylthiourea (ANTU), sodium chromate (Na (2) CrO (4)) or paraquat-(PQ).
The changes of CC16, total protein, albumin, and cystatin-C were determined on BALF supernatan, and CC16, cystatin-C and creatinine levels were also determined in serum.
2(0,0,0,2) Details
12523958 Gulden M, Morchel S, Seibert H: Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay. Toxicol Lett. 2003 Feb 3;137(3):159-68.

The aim of the present study was to measure the influence of albumin binding on cytotoxic concentrations of chemicals and to determine binding parameters which can be used for quantitative in vitro-in vivo extrapolations.
Increasing the BSA concentration either decreased the cytotoxic potency (12 compounds) by factors up to 34 (pentachlorophenol), had no effect (14 compounds), or increased the cytotoxicity (paraquat).
3(0,0,0,3) Details
20097132 Fiedler T, Kreikemeyer B, Sugareva V, Redanz S, Arlt R, Standar K, Podbielski A: Impact of the Streptococcus pyogenes Mga regulator on human matrix protein binding and interaction with eukaryotic cells. Int J Med Microbiol. 2010 Jan 21.

Employing the luc reporter fusions, we showed that the complex growth medium THY-broth decreased mga expression and identified albumin as one component responsible for this effect.
Medium supplementation with the oxidative stressor paraquat or anaerobic growth on THY-agar led to a relatively increased human matrix protein binding of the mga mutant.
2(0,0,0,2) Details
20020887 Geter DR, Kan HL, Lowe ER, Rick DL, Charles GD, Gollapudi BB, Mattsson JL: Investigations of oxidative stress, antioxidant response, and protein binding in chlorpyrifos exposed rat neuronal PC12 cells. Toxicol Mech Methods. 2008;18(1):17-23.

Paraquat served as a positive control for ROS.
Examinations into CPF-albumin binding were also conducted.
2(0,0,0,2) Details