| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11913717 | Hurh E, Lee EJ, Kim YG, Kim SY, Kim SH, Kim YC, Lee MG: Effects of neostigmine on the pharmacokinetics of intravenous parathion in rats. Res Commun Mol Pathol Pharmacol. 2000;108(3-4):261-73. Based on in vitro hepatic microsomal studies, neostigmine inhibited significantly the erythromycin N-demethylase activity (1.03 versus 0.871 nmol/mg protein/min), mainly mediated by hepatic cytochrome P450 3A in rats. |
1(0,0,0,1) | Details |
| 6524963 | Purshottam T, Srivastava RK: Effect of high-fat and high-protein diets on toxicity of parathion and dichlorvos. Arch Environ Health. 1984 Nov-Dec;39(6):425-30. Hepatic microsomal cytochrome P-450 and aminopyrine demethylase activity were unchanged, but hydroxylase activity was increased significantly by HPD and HFD. |
1(0,0,0,1) | Details |
| 6766135 | Halpert J, Hammond D, Neal RA: Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate). J Biol Chem. 1980 Feb 10;255(3):1080-9. The loss of heme is 80% of the loss of cytochrome P-450, which in turn is less than the loss of benzphetamine demethylase activity, the turnover number of the modified enzyme being two-thirds that of the native based on the amount of cytochrome P-450 detectable as its complex. |
1(0,0,0,1) | Details |
| 7082368 | Kulkarni AP, Hodgson E: Mouse liver microsomal hexose-6-phosphate dehydrogenase. Biochem Pharmacol. 1982 Mar 15;31(6):1131-7. The sonicated microsomes exhibited H6PD-linked N-demethylase activity toward aminopyrine. Reaction media containing sonicated microsomes, and deoxyglucose-6- also catalyzed N-demethylation of p-chloro-N-methylaniline, and O-demethylation of p-nitroanisole, p-hydroxylation of ring hydroxylation of biphenyl at the 2- and 4-positions, dearylation of parathion, and the N-oxidation of |
1(0,0,0,1) | Details |
| 7722883 | Lodovici M, Aiolli S, Monserrat C, Dolara P, Medica A, Di Simplicio P: Effect of a mixture of 15 commonly used pesticides on DNA levels of and xenobiotic metabolizing enzymes in rat liver. J Environ Pathol Toxicol Oncol. 1994;13(3):163-8. The level of 8-OH- in rat liver DNA was measured as an index of oxidative damage after treating rats for 10 days at a dose ranging from 0.75 to 10 mg/kg with a mixture of 15 pesticides (dithiocarbamate, benomyl, thiabendazole, diphenylamine, chlorthalonil, procimidone, methidathion, chlorpyrifos-ethyl, fenarimol, parathion-methyl, chlorpropham, parathion, vinclozolin, chlorfenvinphos, pirimiphos-ethyl) commonly found in foods of central Italy. The administration of the pesticide mixture dose dependently reduced benzo (a) pyrene hydroxylase, N-demethylase activities, peroxidase, glutathione reductase, glutathione-S-transferase and thiol transferase activities in the liver. |
1(0,0,0,1) | Details |
| 11514953 | Hurh E, Lee EJ, Kim YG, Kim SY, Kim SH, Kim YC, Lee MG: Effects of physostigmine on the pharmacokinetics of intravenous parathion in rats. Biopharm Drug Dispos. 2000 Nov;21(8):331-8. Based on in vitro rat hepatic microsomal studies, physostigmine inhibited significantly the erythromycin N-demethylase activity (1.03 compared with 0.924 nmol/mg protein/min), mainly mediated by hepatic cytochrome P450 3A in rats. |
1(0,0,0,1) | Details |
| 6710530 | Lapadula DM, Carrington CD, Abou-Donia MB: Induction of hepatic microsomal cytochrome P-450 and inhibition of brain, liver, and plasma esterases by an acute dose of S,S,S-tri-n-butyl phosphorotrithioate (DEF) in the adult hen. Toxicol Appl Pharmacol. 1984 Apr;73(2):300-10. O,O-Diethyl O- phosphorothioate (parathion) and tri-o-cresyl (TOCP) were used as negative and positive controls for organophosphorus-induced delayed neurotoxicity (OPIDN). Oral doses of DEF increased cytochrome P-450 content by 70 to 200% while dermal application caused a 200 to 325% increase over control. p-Chloro-N-methylaniline demethylase was also increased by DEF treatments but to a lesser extent than that of hydroxylase or cytochrome P-450 content. |
1(0,0,0,1) | Details |