| Name | microsomal monooxygenases |
|---|---|
| Synonyms | CPC 8; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; CPC8; CYP2C8; CYPIIC 8; CYPIIC8; Cytochrome P 450 1… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12669189 | Mutch E, Daly AK, Leathart JB, Blain PG, Williams FM: Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?. Arch Toxicol. 2003 Jun;77(6):313-20. Epub 2003 Mar 21. These data indicate that CYP3A4/5 and CYP2C8, which constitute up to 40% of human liver P450s, are the most significant participants in the metabolism of parathion. |
33(0,1,1,3) | Details |
| 16757081 | Mutch E, Williams FM: Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32. Epub 2006 Apr 26. There were significant relationships between paraoxon formation from parathion (5 microM, 20 microM and 200 microM) and the CYP3A4/5, CYP2C8 and CYP1A2 mediated reactions, although only the latter two isoforms correlated significantly with the lowest parathion concentration. |
32(0,1,1,2) | Details |
| 10484078 | Nadin L, Murray M: Participation of CYP2C8 in 4-hydroxylation in human hepatic microsomes. Biochem Pharmacol. 1999 Oct 1;58(7):1201-8. Greater inhibition was produced by the less selective CYP3A inhibitors parathion, quinidine, and ketoconazole; CYP1A inhibitors were ineffective. |
4(0,0,0,4) | Details |
| 7097808 | Yamamoto T, Egashira T, Yoshida T, Kuroiwa Y: Comparison of the effect of an equimolar and low dose of fenitrothion and methylparathion on their own metabolism in rat liver. J Toxicol Sci. 1982 Feb;7(1):35-41. The effects of fenitrothion and methylparathion on the activities of cholinesterase and hepatic microsomal monooxygenases were investigated and compared following a single or repeated oral administration of an equimolar and low dose of the insecticides. |
1(0,0,0,1) | Details |