Protein Information

Name Tyrosinase
Synonyms LB24 AB; Monophenol monooxygenase; OCA1A; OCAIA; SK29 AB; TYR; TYR protein; Tumor rejection antigen AB…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
8381303 Simpson JA, Gieseg SP, Dean RT: Free radical and enzymatic mechanisms for the generation of protein bound reducing moieties. Biochim Biophys Acta. 1993 Feb 13;1156(2):190-6.


Incubations of tyrosinase with BSA or insulin also generated reductive activity.
1(0,0,0,1) Details
7611281 Reish O, Townsend D, Berry SA, Tsai MY, King RA: Tyrosinase inhibition due to interaction of homocyst (e) ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet. 1995 Jul;57(1):127-32.

Copper sulfate restored homocyst (e) ine-inhibited tyrosinase activity when added to the culture cell media at a proportion of 1.25 mol of copper sulfate per 1 mol of DL-homocysteine.
116(1,2,2,6) Details
17287127 Karioti A, Protopappa A, Megoulas N, Skaltsa H: Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum. Bioorg Med Chem. 2007 Apr 1;15(7):2708-14. Epub 2007 Jan 23.

3(0,0,0,3) Details
10547446 Poma A, Pacioni G, Colafarina S, Miranda M: Effect of tyrosinase inhibitors on Tuber borchii mycelium growth in vitro. FEMS Microbiol Lett. 1999 Nov 1;180(1):69-75.

3(0,0,0,3) Details
7849640 Terato H, Yamamoto O: Hydrated electron-induced inactivation of tyrosinase in aqueous solution by exposure to cobalt-60 gamma-rays. Biochem Mol Biol Int. 1994 Sep;34(2):295-300.

2(0,0,0,2) Details
2113847 Cicero R, Gallone A, Maida I, Pintucci G: Effects of copper on the tyrosinase of liver pigment cells from Rana esculenta L. Comp Biochem Physiol B. 1990;96(2):393-7.

2(0,0,0,2) Details
3109385 Lejczak B, Kafarski P, Makowiecka E: Phosphonic analogues of tyrosine and 3,4-dihydroxyphenylalanine (dopa) influence mushroom tyrosinase activity. Biochem J. 1987 Feb 15;242(1):81-8.

2(0,0,0,2) Details
2956123 Huber M, Lerch K: The influence of copper on the induction of tyrosinase and laccase in Neurospora crassa. FEBS Lett. 1987 Jul 27;219(2):335-8.

2(0,0,0,2) Details
3096851 Friedman M, Grosjean OK, Zahnley JC: Inactivation of metalloenzymes by food constituents. Food Chem Toxicol. 1986 Sep;24(9):897-902.


PEAA also inactivated the copper enzyme, polyphenol oxidase (tyrosinase).
2(0,0,0,2) Details
8001175 Marbach K, Fernandez-Larrea J, Stahl U: Reversion of a long-living, undifferentiated mutant of Podospora anserina by copper. Curr Genet. 1994 Aug;26(2):184-6.


The Podospora anserina nuclear mutant grisea displays an undifferentiated growth phenotype (diminished production of aerial hyphae), is female sterile (lack of perithecia), has a prolonged life-span compared to the wild-type strain, and lacks detectable phenoloxidase (laccase and tyrosinase) activity.
1(0,0,0,1) Details
15908724 Tsiskarishvili N: [Cuprum sulfate and vitix in the treatment of vitiligo in children] . Georgian Med News. 2005 Apr;(121):48-51.


It is well known, that melanin is formed from tyrosine by enzyme tyrosinase.
1(0,0,0,1) Details