Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name parathion
CAS

Reference List

PubMed Abstract RScore(About this table)
7599962 Blasiak J: Inhibition of erythrocyte membrane (Ca2+ + Mg2+)-ATPase by the organophosphorus insecticides parathion and methylparathion. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Feb;110(2):119-25.

Organophosphorus insecticides parathion and methylparathion non-competitively inhibited the activity of (Ca2+ + Mg2+)-ATPase bound to and solubilized from pig erythrocyte membrane.
113(1,2,2,3) Details
8579683 Blasiak J: Cooperative binding of the organophosphate paraoxon to the (Na+ + K+)-ATPase. Z Naturforsch C. 1995 Sep-Oct;50(9-10):660-3.

Paraoxon, the main active metabolite of the organophosphorus insecticide parathion, exerted a dose-dependent inhibitory effect on the activity of pig kidney (Na+ + K+)-ATPase contained in microsomal fraction and purified from it.
83(1,1,1,3) Details
1380492 Nayeemunnisa, Begum S: Methyl parathion induced regional alterations in the regulatory proteins during critical stage of central nervous system development in albino rat pups. Indian J Physiol Pharmacol. 1992 Apr;36(2):77-82.

Sublethal doses of methyl parathion (O,O-dimethyl-O-nitrophenyl- thiophosphate) injected intraperitoneally to 15 and 21 day old rat pups induced regional alterations in the central nervous system (CNS) in the levels of total RNA, total proteins, modulatory protein Calmodulin (CaM), in the activity levels of membrane bound enzyme Ca (2+)-ATPase and phospholipids.
62(0,2,2,2) Details
6229905 Prasada Rao KS, Ramana Rao KV: Tissue specific alteration of aminotransferases and total ATPases in the fish (Tilapia mossambica) under methyl parathion impact. Toxicol Lett. 1984 Jan;20(1):53-7.

The activity levels of aspartate aminotransferase (AAT), alanine aminotransferase (AlAT) and total adenosine triphosphatase (ATPase) were studied in muscle, gill, liver and brain tissues of control and methyl parathion exposed (MPE) fish.
7(0,0,1,2) Details
6148952 Dierkes-Tizek U, Glaser U, Oldiges H, Hettwer H: [The effect of organophosphates on heart ATPase in the rat] . Arzneimittelforschung. 1984;34(6):671-8.

The effect of organophosphate intoxication with diisopropylfluorophosphate (DFP), paraoxon and parathion on the activity of some ATPases of rat hearts was examined.
5(0,0,0,5) Details
11393797 Barber D, Hunt J, Ehrich M: Inhibition of calcium-stimulated ATPase in the hen brain P2 synaptosomal fraction by organophosphorus esters: relevance to delayed neuropathy. J Toxicol Environ Health A. 2001 May 25;63(2):101-13.

Following in vitro exposure to 10 (-3) to 10 (-5) M OP compounds, Ca-stimulated ATPase activity was inhibited by chlorpyrifos, chlorpyrifos-oxon, phenyl saligenin phosphate (PSP), and tri-o-tolyl phosphate (TOTP), but not by parathion, paraoxon, or diisopropyl fluorophosphate (DFP).
3(0,0,0,3) Details
2151019 Reddy MS, Rao KV: In vitro inhibition of Ca+2 ATPase by methylparathion in prawn: a kinetic approach. Biochem Int. 1990 Dec;22(6):1053-8.

3(0,0,0,3) Details
15978292 Comoglio L, Amin O, Roque A, Betancourt-Lozano M, Anguas D, Haro BM: Evaluation of sublethal biomarkers in Litopenaeus vannamei on foodborne exposure to methyl parathion. Ecotoxicol Environ Saf. 2005 Sep;62(1):66-74. Epub 2004 Dec 15.

The total-ATPase activity was significantly lower in controls than in pesticide treatments (control=77.90+/-12.41; solvent control = 83.69 +/- 22.05; 0.62 = 110.03 +/- 22.17; 1.31 = 121.54 +/- 19.84 microM P (i)*h (-1)*mgprotein (-1)).
3(0,0,0,3) Details
17490606 Sreeramulu K, Liu R, Sharom FJ: Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. Biochim Biophys Acta. 2007 Jul;1768(7):1750-7. Epub 2007 Apr 5.


All the pesticides stimulated P-glycoprotein ATPase activity, with maximum stimulation of up to 213% in a detergent-solubilized preparation, and up to 227% in reconstituted liposomes.
2(0,0,0,2) Details
2559113 Jaramillo-Juarez F, Posadas del Rio FA, Reyes JL, Rodriguez ML, Sanchez EI, Cuellar LH: Effects of intrauterine exposure to parathion on the activity of renal ATPases in offspring. J Appl Toxicol. 1989 Dec;9(6):401-5.

We found a decrease in the enzymatic activity of total ATPases, at the expense of the Mg2+-dependent ATPase.
1(0,0,0,1) Details
11076 Price NR: The effect of two insecticides on the Ca2+ + Mg2+ -activated ATPase of the sarcoplasmic reticulum of the flounder, Platichthys flesus. Comp Biochem Physiol C. 1976;55(2):91-4.

1(0,0,0,1) Details