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Chavez J, Segura P, Vargas MH, Arreola JL, Flores-Soto E, Montano LM: Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release. Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L915-23. Epub 2006 Dec 8.
In in vivo experiments, parathion caused a progressive bronchoobstruction until a plateau was reached.
This paradoxical recontraction was avoided by the M2- or neurokinin-1 (NK1)-receptor antagonists (methoctramine or AF-DX 116, and L-732138, respectively), accompanied by a long-lasting relaxation. |
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