| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 755667 | Dalvi RR, Howell CD: Interaction of parathion and malathion with hepatic cytochrome P-450 from rats treated with phenobarbital and carbon disulfide. Drug Chem Toxicol. 1978;1(2):191-202. |
113(1,2,2,3) | Details |
| 5264 | Kamataki T, Lee Lin MC, Belcher DH, Neal RA: Studies of the metabolism of parathion with an apparently homogeneous preparation of rabbit liver cytochrome P-450. Drug Metab Dispos. 1976 Mar-Apr;4(2):180-9. These studies revealed that the apparently homogeneous preparation of cytochrome P-450, in the presence of the appropriate cofactors, can catalyze the conversions of parathion to both paraoxon and diethyl phosphorothioic acid. |
113(1,2,2,3) | Details |
| 7696534 | Murray M, Butler AM: Hepatic biotransformation of parathion: role of cytochrome P450 in - and -mediated microsomal oxidation in vitro. Chem Res Toxicol. 1994 Nov-Dec;7(6):792-9. In vitro studies have established that cytochrome P450 (P450) is deactivated by the electrophilic released during the enzymic oxidation of parathion to paraoxon. |
112(1,2,2,2) | Details |
| 7853177 | Murray M, Butler AM: Identification of a reversible component in the in vitro inhibition of rat hepatic cytochrome P450 2B1 by parathion. J Pharmacol Exp Ther. 1995 Feb;272(2):639-44. |
112(1,2,2,2) | Details |
| 2339415 | Chambers JE, Chambers HW: Time course of inhibition of acetylcholinesterase and aliesterases following parathion and paraoxon exposures in rats. Toxicol Appl Pharmacol. 1990 May;103(3):420-9. The effects of pretreatment with cytochrome P450 inducers and inhibitors were also investigated. |
1(0,0,0,1) | Details |
| 14669870 | Jauregui J, Valderrama B, Albores A, Vazquez-Duhalt R: Microsomal transformation of organophosphorus pesticides by white rot fungi. Biodegradation. 2003 Dec;14(6):397-406. These results, supported by specific inhibition experiments and the stringent requirement for during the in vitro assays suggest the involvement of a cytochrome P450. With the exception of Ganoderma applanatum 8168, all strains from a collection of 17 different fungi cultures were able to deplete parathion. |
1(0,0,0,1) | Details |
| 12620367 | Buratti FM, Volpe MT, Meneguz A, Vittozzi L, Testai E: CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Toxicol Appl Pharmacol. 2003 Feb 1;186(3):143-54. The bioactivation of azinphos-methyl (AZIN), chlorpyrifos (CPF), diazinon (DIA), and parathion (PAR), four widely used organophosphorothioate (OPT) pesticides has been investigated in human liver microsomes (HLM). In addition, the role of human cytochrome P450 (CYPs) in OPT desulfuration at pesticide levels representative of human exposure have been defined by means of correlation and immunoinhibition studies. |
1(0,0,0,1) | Details |
| 11422509 | Scharf ME, Parimi S, Meinke LJ, Chandler LD, Siegfried BD: Expression and induction of three family 4 cytochrome P450 (CYP4)* genes identified from insecticide-resistant and susceptible western corn rootworms, Diabrotica virgifera virgifera. Insect Mol Biol. 2001 Apr;10(2):139-46. We have previously determined that cytochrome P450-based oxidation is involved in resistance to the insecticides methyl parathion and carbaryl in geographically distinct Nebraska western corn rootworm populations. |
83(1,1,1,3) | Details |
| 6093289 | Selgrade MK, Daniels MJ, Illing JW, Ralston AL, Grady MA, Charlet E, Graham JA: Increased susceptibility to parathion poisoning following murine cytomegalovirus infection. Toxicol Appl Pharmacol. 1984 Nov;76(2):356-64. The time frame during which enhanced sensitivity to parathion and pentobarbital was observed suggests that this sensitivity may have been caused by viral-induced interferon-mediated depression of cytochrome P-450. |
82(1,1,1,2) | Details |
| 11514953 | Hurh E, Lee EJ, Kim YG, Kim SY, Kim SH, Kim YC, Lee MG: Effects of physostigmine on the pharmacokinetics of intravenous parathion in rats. Biopharm Drug Dispos. 2000 Nov;21(8):331-8. The above data suggested that parathion was metabolized to paraoxon by dexamethasone-inducible hepatic cytochrome P450 (CYP) 3A in rats. |
82(1,1,1,2) | Details |
| 2869902 | Christian MF, Yu SJ: Cytochrome P-450-dependent monooxygenase activity in the velvetbean caterpillar, Anticarsia gemmatalis Hubner. Comp Biochem Physiol C. 1986;83(1):23-7. Piperonyl butoxide decreased and increased the toxicity of methomyl and methyl parathion, respectively, suggesting that the monooxygenase system of velvetbean caterpillars plays a major role in the detoxification of xenobiotics. |
1(0,0,0,1) | Details |
| 12088537 | Fragoso DB, Guedes RN, Guedes RN, Picanco MC, Zambolim L: Insecticide use and organophosphate resistance in the coffee leaf miner Leucoptera coffeella (Lepidoptera: Lyonetiidae). Bull Entomol Res. 2002 Jun;92(3):203-12. Increasing rates of insecticide use against the coffee leaf minerLeucoptera coffeella (Guerin-Meneville) and field reports on insecticide resistance led to an investigation of the possible occurrence of resistance of this species to some of the oldest insecticides used against it in Brazil: chlorpyrifos, disulfoton, ethion and methyl parathion. Results from insecticide bioassays with synergists (diethyl piperonyl butoxide and triphenyl suggested that cytochrome P450-dependent monooxygenases may play a major role in resistance with minor involvement of esterases and glutathione S-transferases. |
1(0,0,0,1) | Details |
| 11245398 | Gelal A, Gumustekin M, Kalkan S, Guven H, Eminoglu O: Effects of subchronic parathion exposure on cyclosporine pharmacokinetics in rats. J Toxicol Environ Health A. 2001 Feb 23;62(4):289-94. Parathion undergoes enzymatic oxidation by hepatic cytochrome P-450 (CYP450) enzymes to the active metabolite paraoxon. |
82(1,1,1,2) | Details |
| 11913717 | Hurh E, Lee EJ, Kim YG, Kim SY, Kim SH, Kim YC, Lee MG: Effects of neostigmine on the pharmacokinetics of intravenous parathion in rats. Res Commun Mol Pathol Pharmacol. 2000;108(3-4):261-73. The above data suggested that parathion was metabolized to paraoxon by dexamethasone-inducible hepatic cytochrome P450 (CYP) 3A in rats. |
82(1,1,1,2) | Details |
| 9439736 | Atterberry TT, Burnett WT, Chambers JE: Age-related differences in parathion and chlorpyrifos toxicity in male rats: target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism. Toxicol Appl Pharmacol. 1997 Dec;147(2):411-8. |
82(1,1,1,2) | Details |
| 8896566 | Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, Furlong CE: The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat Genet. 1996 Nov;14(3):334-6. The insecticides parathion, chlorpyrifos and diazinon are bioactivated to potent cholinesterase inhibitors by cytochrome P-450 systems. |
81(1,1,1,1) | Details |
| 7514706 | Chambers JE, Ma T, Boone JS, Chambers HW: Role of detoxication pathways in acute toxicity levels of phosphorothionate insecticides in the rat. Life Sci. 1994;54(18):1357-64. Cytochrome P450-mediated dearylation activity was higher in males than in females. |
1(0,0,0,1) | Details |
| 8285 | Boyd MR, Neal RA: Studies on the mechanism of toxicity and of development of tolerance to the pulmonary toxin, alpha-naphthylthiourea (ANTU). Drug Metab Dispos. 1976 Jul-Aug;4(4):314-22. This covalent binding, which requires leads to a decrease in mixed-function oxidase activity and to a decrease in the level of cytochrome P-450 detectable as its complex. Pretreatment of rats with small nonlethal doses of ANTU daily for 5 days brings about a decrease in the activity of the mixed-function oxidase enzyme system in the lung which metabolizes parathion. |
1(0,0,0,1) | Details |
| 17079358 | Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR: Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos. Drug Metab Dispos. 2007 Feb;35(2):189-93. Epub 2006 Nov 1. |
81(1,1,1,1) | Details |
| 12625227 | Lee BW, London L, Paulauskis J, Myers J, Christiani DC: Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers. J Occup Environ Med. 2003 Feb;45(2):118-22. Pesticides, such as parathion, are metabolized by cytochrome p-450 system to paraoxon, which is a potent cholinesterase inhibitor. |
81(1,1,1,1) | Details |
| 11180198 | Hurh E, Lee E, Lee A, Kim Y, Kim S, Kim S, Lee M: Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats. Biopharm Drug Dispos. 2000 Jul;21(5):193-204. In order to find what form of hepatic cytochrome P450 (CYP) is involved in the metabolism of parathion to form paraoxon, rats were pretreated with the enzyme inhibitors, such as SKF 525-A and ketoconazole or enzyme inducers, such as dexamethasone, isoniazid, phenobarbital, and 3-methylcholanthrene. |
81(1,1,1,1) | Details |
| 19399609 | Brausch JM, Smith PN: Development of resistance to cyfluthrin and naphthalene among Daphnia magna. Ecotoxicology. 2009 Jul;18(5):600-9. Epub 2009 Apr 28. Cyfluthrin exposed D. magna exhibited cross-resistance to DDT and methyl parathion, and naphthalene resistant D. magna were less sensitive than controls to both pyrene and benz (a) anthracene. When the cytochrome P450 inhibitor piperonyl butoxide was used in conjunction with cyfluthrin and naphthalene the sensitivity of resistant and control D. magna were equal, suggesting P450s were responsible for conveying resistance. |
1(0,0,0,1) | Details |
| 19253540 | Na H, Huang Q, Chen Y, Huang H: [Differential proteins revealed with proteomics in the brain tissue of Paralichthys olivaceus under the stress of methyl parathion]. Se Pu. 2008 Nov;26(6):662-6. The results showed that heat shock protein 70, glutathione S-transferase and cytochrome P450 were significantly found in those differential proteins. |
1(0,0,0,1) | Details |
| 1539180 | Soranno TM, Sultatos LG: Biotransformation of the insecticide parathion by mouse brain. . Toxicol Lett. 1992 Jan;60(1):27-37. The present study is directed towards the characterization of cytochrome-P450-dependent metabolism of parathion by various mouse brain regions. |
81(1,1,1,1) | Details |
| 7040015 | Halpert J, Neal RA: Inactivation of rat liver cytochrome P-450 by the suicide substrates parathion and chloramphenicol. Drug Metab Rev. 1981;12(2):239-59. |
81(1,1,1,1) | Details |
| 9928630 | Ramos S, Sultatos L: -induced alterations in cytochrome P450-dependent biotransformation of the organophosphorus insecticide parathion in the mouse. Toxicology. 1998 Nov 16;131(2-3):155-67. These data suggest that the changes in the activation/detoxification ratio observed with mouse hepatic microsomes resulted from selective inhibition or stimulation of various cytochrome P450 isoforms rather than a -induced alteration in the nonenzymatic rearrangement of the putative phosphooxythirane intermediate generated by cytochromes P450 from parathion. |
45(0,1,3,5) | Details |
| 1510613 | Popovic M, Dakovic-Svajcer K, Nerudova J: [Xenobiotic and biochemical parameters of isolated rat hepatocytes] . Arh Hig Rada Toksikol. 1992 Mar;43(1):21-7. The authors investigated the effects of the inductors (griseofulvin and fenitoin) and the inhibitors of the cytochrome P-450 (metronidazole, chloramphenicol and phenylbutazone), the effects of the drugs with the structure xanthinol- pentoxiphylline, azathioprine, thioguanine, 6-mercaptopurine), and the effects of several pesticides (lindane, binapicrile, parathion) on some biochemical parameters of the rat liver. |
32(0,1,1,2) | Details |
| 10930656 | Straus1 DL, Schlenk D, Chambers JE: Hepatic microsomal desulfuration and dearylation of chlorpyrifos and parathion in fingerling channel catfish: lack of effect from Aroclor 1254. Aquat Toxicol. 2000 Aug 1;50(1-2):141-151. Channel catfish were treated intraperitoneally with 100 mg Aroclor 1254/kg body weight and sacrificed at 96 h to observe the effects of this cytochrome P450 1A (CYP1A) inducer on chlorpyrifos and parathion metabolism. |
1(0,0,0,1) | Details |
| 3138981 | Lambrecht RW, Sinclair PR, Bement WJ, Sinclair JF, Carpenter HM, Buhler DR, Urquhart AJ, Elder GH: Hepatic uroporphyrin accumulation and uroporphyrinogen decarboxylase activity in cultured chick-embryo hepatocytes and in Japanese quail (Coturnix coturnix japonica) and mice treated with polyhalogenated aromatic compounds. Biochem J. 1988 Jul 1;253(1):131-8. Other compounds, such as hexachlorobenzene, parathion, carbamazepine and nifedipine, which have been shown previously to cause uroporphyrin accumulation in these cells, did not decrease uroporphyrinogen decarboxylase activity. Our results with chick hepatocytes and quail, showing uroporphyrin accumulation without a decrease in uroporphyrinogen decarboxylase activity, are consistent with a new two-stage model of the uroporphyria: initially uroporphyrinogen is oxidized by a cytochrome P-450-mediated reaction, followed in rodents by a progressive decrease in uroporphyrinogen decarboxylase activity. |
1(0,0,0,1) | Details |
| 15018574 | Schulze H, Schmid RD, Bachmann TT: Activation of phosphorothionate pesticides based on a cytochrome P450 BM-3 (CYP102 A1) mutant for expanded neurotoxin detection in food using acetylcholinesterase biosensors. Anal Chem. 2004 Mar 15;76(6):1720-5. In contrast, a genetically engineered triple mutant of P450 BM-3 (CYP102 A1) could convert the two frequently used insecticides parathion and chlorpyrifos into their oxo variants as was confirmed by GC/MS measurements. |
1(0,0,0,1) | Details |
| 8316222 | Butler AM, Murray M: Inhibition and inactivation of constitutive cytochromes P450 in rat liver by parathion. Mol Pharmacol. 1993 Jun;43(6):902-8. In hepatic microsomal fractions, the -mediated conversion of parathion to paraoxon occurs with concomitant loss of cytochrome P450 (P450) and associated activities. |
31(0,1,1,1) | Details |
| 11481665 | Abu-Qare AW, Abou-Donia MB: Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats. J Appl Toxicol. 2001 Jul-Aug;21(4):307-16. The lower inhibitory effect of the combination of methyl parathion and diazinon might be due to competition of diazinon with methyl parathion for cytochrome P-450 enzymes, resulting in formation of the potent cholinesterase inhibitor methyl paraoxon. |
31(0,1,1,1) | Details |
| 15690761 | Murray M, Butler AM: Comparative inhibition of inducible and constitutive CYPs in rat hepatic microsomes by parathion. Xenobiotica. 2004 Aug;34(8):723-39. In microsomal fractions, the phosphorothioate pesticide parathion inhibits cytochrome P450 (CYP) enzymes by reversible and irreversible mechanisms resulting in the long-term suppression of drug oxidation. |
31(0,1,1,1) | Details |
| 9179985 | Lee HS, Jeong S, Kim K, Kim JH, Lee SK, Kang BH, Roh JK: In vitro metabolism of the new insecticide flupyrazofos by rat liver microsomes. Xenobiotica. 1997 May;27(5):423-9. Cytochrome P450 oxidatively converted flupyrazofos to flupyrazofos oxon, a major metabolite and phenobarbital-induced microsomes increased this desulphuration by 8-fold. 3. |
1(0,0,0,1) | Details |
| 12669189 | Mutch E, Daly AK, Leathart JB, Blain PG, Williams FM: Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?. Arch Toxicol. 2003 Jun;77(6):313-20. Epub 2003 Mar 21. |
1(0,0,0,1) | Details |
| 7871535 | Ronis MJ, Badger TM: Toxic interactions between fungicides that inhibit biosynthesis and phosphorothioate insecticides in the male rat and bobwhite quail (Colinus virginianus). Toxicol Appl Pharmacol. 1995 Feb;130(2):221-8. Induction of cytochrome P450 in rat and quail liver by EBIFs was accompanied by enhanced oxidative desulfuration of malathion, parathion, and diazinon to toxic oxon products. |
31(0,1,1,1) | Details |
| 7562954 | Ma T, Chambers JE: A kinetic analysis of hepatic microsomal activation of parathion and chlorpyrifos in control and phenobarbital-treated rats. J Biochem Toxicol. 1995 Apr;10(2):63-8. A kinetic analysis of cytochrome P450-mediated desulfuration (activation) or dearylation (detoxication) showed that rat hepatic microsomes have a greater capacity to detoxify and a lower capacity to activate chlorpyrifos compared to parathion. |
31(0,1,1,1) | Details |
| 9750043 | Agyeman AA, Sultatos LG: The actions of the H2-blocker cimetidine on the toxicity and biotransformation of the phosphorothioate insecticide parathion. Toxicology. 1998 Jul 17;128(3):207-18. Parathion, like most organophosphorus insecticides currently in use, must undergo cytochrome P450 (P450)-dependent activation in order to exert its acute mammalian toxicity (cholinergic crisis). |
31(0,1,1,1) | Details |
| 859108 | Davis JE, Mende TJ: A study of the binding of to rat liver microsomes which occurs concurrently with the metabolism of O, O-diethyl O-p-nitrophenyl phosphorothioate (parathion) to O, O-diethyl O-p-nitrophenyl (paraoxon). J Pharmacol Exp Ther. 1977 May;201(2):490-7. Preliminary investigations revealed similar binding occurs when the microsomal preparation is replaced with purified rabbit cytochrome P-450 plus -cytochrome P-450 reductase and |
1(0,0,0,1) | Details |
| 470553 | Martinez-Zedillo G, Castilho-Alonso C, Magdaleno VM, Gonzalez-Angulo A: Cytochrome P-450 and parathion metabolism in the fetal and adult gonads of the horse. Life Sci. 1979 Jul 23;25(4):327-32. |
1(0,0,0,1) | Details |
| 19402758 | Weil M, Scholz S, Zimmer M, Sacher F, Duis K: Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the fish early life stage test. Environ Toxicol Chem. 2009 Sep;28(9):1970-8. The effects of 14 substances on lethal and sublethal endpoints of the DarT and on expression of potential marker genes were investigated: the aryl hydrocarbon receptor 2, cytochrome P450 1A (cypla), heat shock protein 70, fizzy-related protein 1, the transcription factors v-maf musculoaponeurotic fibrosarcoma oncogene family protein g (avian) 1 and NF-E2-p45-related factor, and heme oxygenase 1 (hmox1). For 10 (3,4- and 3,5-dichloroaniline, 1,4-dichlorobenzene, 2,4-dinitrophenol, atrazine, parathion-ethyl, chlorotoluron, 4-nitroquinoline-1-oxide, and cadmium) out of the 14 tested substances, LOEC values derived with the Gene-DarT differ by a factor of less than 10 from LOEC values of fish early life stage tests with zebrafish. |
1(0,0,0,1) | Details |
| 9023313 | Butler AM, Murray M: Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. J Pharmacol Exp Ther. 1997 Feb;280(2):966-73. Studies in rat liver have shown that cytochrome P450 (CYP) enzymes mediate the oxidative biotransformation of the phosphorothioate pesticide parathion to paraoxon and |
31(0,1,1,1) | Details |
| 826783 | Kamataki T, Belcher DH, Neal RA: Studies of the metabolism of diethyl p-nitrophenyl phosphorothionate (parathion) and benzphetamine using an apparently homogeneous preparation of rat liver cytochrome P-450: effect of a cytochrome P-450 antibody preparation. Mol Pharmacol. 1976 Nov;12(6):921-32. |
31(0,1,1,1) | Details |
| 10619188 | Segura P, Chavez J, Montano LM, Vargas MH, Delaunois A, Carbajal V, Gustin P: Identification of mechanisms involved in the acute airway toxicity induced by parathion. Naunyn Schmiedebergs Arch Pharmacol. 1999 Dec;360(6):699-710. The isolated perfused rabbit lung preparation was used to study the acute effects of Pth on airway responsiveness to (10 (-8)-10 (-3) M), (10 (-8)-10 (-3) M) and substance P (10 (-10)-10 (-6) M), pulmonary acetylcholinesterase inhibition and cytochrome P450 (P450) activity, and their modifications with previous administration of Pth (1 mg/kg s.c. daily, 7 days). |
1(0,0,0,1) | Details |
| 3026315 | Sinclair PR, Bement WJ, Bonkovsky HL, Lambrecht RW, Frezza JE, Sinclair JF, Urquhart AJ, Elder GH: Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Biochem J. 1986 Jul 1;237(1):63-71. In a previous paper, an isoenzyme of cytochrome P-450 induced by 3-methylcholanthrene had been implicated in this process [Sinclair, Bement, Bonkovsky & Sinclair (1984) Biochem. Piperonyl butoxide also reversed uroporphyrin accumulation caused by 3,4,5,3',4',5'-hexachlorobiphenyl, mixtures of other halogenated biphenyls, lindane, parathion, nifedipine and |
1(0,0,0,1) | Details |
| 11405414 | Abu-Qare AW, Abdel-Rahman A, Brownie C, Kishk AM, Abou-Donia MB: Inhibition of cholinesterase enzymes following a single dermal dose of chlorpyrifos and methyl parathion, alone and in combination, in pregnant rats. J Toxicol Environ Health A. 2001 Jun 8;63(3):173-89. The lower inhibitory effect of the combination could be due to competition between chlorpyrifos and methyl parathion for cytochrome P-450 enzymes, resulting in inhibition of the formation of the potent cholinesterase inhibitor oxon forms. |
31(0,1,1,1) | Details |
| 6193025 | Sultatos LG, Murphy SD: Kinetic analyses of the microsomal biotransformation of the phosphorothioate insecticides chlorpyrifos and parathion. Fundam Appl Toxicol. 1983 Jan-Feb;3(1):16-21. This complex kinetic behavior could arise as a result of competitive interactions of parathion and chlorpyrifos with multiple forms of microsomal cytochrome P-450. |
31(0,1,1,1) | Details |
| 7520881 | Ma T, Chambers JE: Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microsomes. Food Chem Toxicol. 1994 Aug;32(8):763-7. A kinetic analysis of cytochrome P-450 mediated desulfuration (activation) and dearylation (detoxication) of the two insecticides indicated that rat hepatic microsomes have a higher capacity to activate and a lower capacity to detoxify parathion than chlorpyrifos; these capacities correspond to their acute toxicity levels. |
31(0,1,1,1) | Details |
| 1412461 | Delaunois A, Gustin P, Ansay M: Altered capillary filtration coefficient in parathion- and paraoxon-induced edema in isolated and perfused rabbit lungs. Toxicol Appl Pharmacol. 1992 Oct;116(2):161-9. Piperonyl butoxide (4 x 10 (-4) M), an inhibitor of cytochrome P450, had a strong protective effect against Pth (4 x 10 (-4) M)-induced alterations of endothelium permeability (n = 5, p < 0.001). |
1(0,0,0,1) | Details |
| 8658521 | Lessire F, Gustin P, Delaunois A, Bloden S, Nemmar A, Vargas M, Ansay M: Relationship between parathion and paraoxon toxicokinetics, lung metabolic activity, and cholinesterase inhibition in guinea pig and rabbit lungs. Toxicol Appl Pharmacol. 1996 Jun;138(2):201-10. |
0(0,0,0,0) | Details |
| 7059232 | Purshottam T, Kaveeshwar U: Effect of phenobarbitol pretreatment on regeneration of plasma cholinesterase activity inhibited by parathion or dichlorovos. Arch Environ Health. 1982 Jan-Feb;37(1):53-8. |
0(0,0,0,0) | Details |
| 1268038 | Seawright AA, Hrdlicka J, DeMatteis F: The hepatotoxicity of O,O-diethyl, O-phenyl phosphorothionate (SV1) for the rat. Br J Exp Pathol. 1976 Feb;57(1):16-22. The parathion analogue O, O-diethyl, O-phenyl phosphorothionate (SV1) is hepatotoxic when given in large intraperitoneal doses (400 mg/kg body weight) to male rats that have been treated previously with phenobarbitone. |
0(0,0,0,0) | Details |
| 14658504 | Wright RJ, Scharf ME, Meinke LJ, Zhou X, Siegfried BD, Chandler LD: Larval susceptibility of an insecticide-resistant western corn rootworm (Coleoptera: Chrysomelidae) population to soil insecticides: laboratory bioassays, assays of detoxification enzymes, and field performance. J Econ Entomol. 2000 Feb;93(1):7-13. Resistance ratios (LD50 Phelps County/LD50 Saunders County) for the insecticides methyl parathion, tefluthrin, carbofuran, terbufos, and chlorpyrifos were 28.0, 9.3, 8.7, 2.6 and 1.3, respectively. |
0(0,0,0,0) | Details |
| 10996483 | Sams C, Mason HJ, Rawbone R: Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes. Toxicol Lett. 2000 Aug 16;116(3):217-21. The role of specific cytochrome P450 isoforms in catalysing the oxidative biotransformation of the organophosphorothioate pesticides parathion, chlorpyrifos and diazinon into structures that inhibit cholinesterase has been investigated in human liver microsomes using chemical inhibitors. |
31(0,1,1,1) | Details |
| 6896554 | Sawahata T, Neal RA: Inhibition of rat liver cytochrome P-450 by benzyl hydrodisulfide. Mol Pharmacol. 1982 Mar;21(2):464-7. A similar alteration in the heme moiety of cytochrome P-450 is believed to be responsible, in part, for the loss of monooxygenase activity and cytochrome P-450 seen on incubation of parathion and other thiono--containing compounds with hepatic microsomes or a reconstituted cytochrome P-450-containing monooxygenase system. |
11(0,0,1,6) | Details |
| 8511793 | Veronesi B, Ehrich M: Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides. Toxicol Appl Pharmacol. 1993 Jun;120(2):240-6. B-lymphoblastoids, genetically engineered with human P450 cDNAs, demonstrated higher cytotoxic sensitivity to parathion than unengineered cells, indicating that cytochrome P450-associated monooxidase activity could also influence cytotoxic sensitivity to parathion in culture. |
6(0,0,1,1) | Details |
| 11886776 | Tsagkarakou A, Pasteur N, Cuany A, Chevillon C, Navajas M: Mechanisms of resistance to organophosphates in Tetranychus urticae (Acari: Tetranychidae) from Greece. Insect Biochem Mol Biol. 2002 Apr;32(4):417-24. We investigated the mechanisms conferring resistance to methyl-parathion (44-fold) and to methomyl (8-fold) in Tetranychus urticae from Greece by studying the effect of synergists on the resistance and the kinetic characteristics of various enzymes in a resistant strain (RLAB) and a susceptible reference strain (SAMB). |
0(0,0,0,0) | Details |
| 6138207 | Yawetz A, Sidis I, Gasith A: Metabolism of parathion and brain cholinesterase inhibition in aroclor 1254-treated and untreated Caspian terrapin (Mauremys caspica rivulata, Emydidae, Chelonia) in comparison with two species of wild birds. Comp Biochem Physiol C. 1983;75(2):377-82. |
0(0,0,0,0) | Details |
| 11701217 | Abu-Qare AW, Abdel-Rahman AA, Ahmad H, Kishk AM, Abou-Donia MB: Absorption, distribution, metabolism and excretion of daily oral doses of [14C] methyl parathion in hens. Toxicol Lett. 2001 Dec 15;125(1-3):1-10. The slow elimination rate of methyl parathion is significant, since hens are more comparable to humans with respect to their cytochrome P450 activities. |
6(0,0,1,1) | Details |
| 3983973 | Levi PE, Hodgson E: Oxidation of pesticides by purified cytochrome P-450 isozymes from mouse liver. Toxicol Lett. 1985 Feb-Mar;24(2-3):221-8. The pesticides parathion, fonofos, DEF, Mocap and profenofos were oxidized by the reconstituted monooxygenase system to form acetylcholinesterase (AChE) inhibitors. |
6(0,0,0,6) | Details |
| 2484116 | Popovic M, Dakovic-Svajcer K, Nerudova J, Trivic S: [Pesticides and liver biochemistry] . Arh Hig Rada Toksikol. 1989 Sep;40(3):277-83. The effects of various pesticides (lindane, binapacrile and parathion) on the content of cytochrome P450 and and on the activity of lipoperoxidase, xanthine oxidase and transaminases (SGOT and SPGT) were examined. |
6(0,0,1,1) | Details |
| 10562694 | Delaunois A, Florquin S, Segura P, Montano LM, Vargas MH, Gustin P: Interactions between cytochrome P-450 activities and ozone-induced modulatory effects on endothelial permeability in rabbit lungs: influence of gender. Inhal Toxicol. 1999 Nov;11(11):999-1014. Some lungs were used for preparation of microsomes and measurement of 7-ethoxyresorufin O-deethylase (EROD) and parathion oxidase activities. |
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| 7044288 | Neal RA, Halpert J: Toxicology of thiono- compounds. Annu Rev Pharmacol Toxicol. 1982;22:321-39. These toxic effects of thiono--containing compounds appear to be at least partially the result of their metabolism to reactive intermediates by the cytochrome P-450-containing monooxygenase enzyme systems. |
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| 2874799 | Guengerich FP: Covalent binding to apoprotein is a major fate of heme in a variety of reactions in which cytochrome P-450 is destroyed. Biochem Biophys Res Commun. 1986 Jul 16;138(1):193-8. A major fraction of the heme label was irreversibly bound to apoprotein in all cases, including incubations with fluroxene, 1-octene, vinyl trichloroethylene, vinyl parathion, cumene hydroperoxide, NaN3, or iron- complex. |
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| 15893924 | Waibel M, Schulze H, Huber N, Bachmann TT: Screen-printed bienzymatic sensor based on sol-gel immobilized Nippostrongylusbrasiliensis acetylcholinesterase and a cytochrome P450 BM-3 (CYP102-A1) mutant. Biosens Bioelectron. 2006 Jan 15;21(7):1132-40. The enzyme sol-gel itself already proved to be suitable for the highly sensitive detection of paraoxon and parathion in a spectrometric assay. |
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| 6710530 | Lapadula DM, Carrington CD, Abou-Donia MB: Induction of hepatic microsomal cytochrome P-450 and inhibition of brain, liver, and plasma esterases by an acute dose of S,S,S-tri-n-butyl phosphorotrithioate (DEF) in the adult hen. Toxicol Appl Pharmacol. 1984 Apr;73(2):300-10. O,O-Diethyl O- phosphorothioate (parathion) and tri-o-cresyl (TOCP) were used as negative and positive controls for organophosphorus-induced delayed neurotoxicity (OPIDN). |
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| 2859168 | Osimitz TG, Kulkarni AP: Polyamine effects on cytochrome P-450- and flavin-containing monooxygenase-mediated oxidation of xenobiotics. Drug Metab Dispos. 1985 Mar-Apr;13(2):197-203. and all caused a different degree of stimulation of oxidative dearylation of parathion and O-ethyl-O-p-nitrophenylphosphonothioate, epoxidation of aldrin, and O-deethylation of 7-ethoxycoumarin. |
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| 15557345 | Buratti FM, D'Aniello A, Volpe MT, Meneguz A, Testai E: Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms. Drug Metab Dispos. 2005 Mar;33(3):295-302. Epub 2004 Nov 22. These results are in line with those found with chlorpyrifos, diazinon, azynphos-methyl, and parathion, characterized by the presence of an aromatic ring in the molecule. |
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| 405388 | Guengerich FP: Separation and purification of multiple forms of microsomal cytochrome P-450. J Biol Chem. 1977 Jun 10;252(11):3970-9. |
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| 1489528 | Yang M, Luo Y, Liu Y: Potential use of luminol-dependent chemiluminescence for estimation of free radicals produced in hepatic microsomes and reconstituted cytochrome P-450 systems. Biomed Environ Sci. 1992 Dec;5(4):336-48. The study of CL in detecting free radicals formed by biotransformation of 44 xenobiotics suggested that some of the compounds known as free radicals producing agents by bioactivation increased the light emission in cytochrome P-450 enzyme system, such as carbon tetrachloride, chloroform, tetrachloroethylene etc., the others forming toxic metabolites by biotransformation induced the CL in some cases, such as carbon disulfide, methyldursban, methylparathion etc. or decreased the light emission, such as parathion, and polychlorinated byphenyls etc., and still others whose toxic effects have no relationship with their biotransformation had no influence or an inhibitory effect on the CL, such as aminopyrine, TOCP, and acrylamide. |
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| 3178883 | Nemery B, Aldridge WN: Studies on the metabolism of the pneumotoxin O,S,S-trimethyl phosphorodithioate--II. Biochem Pharmacol. 1988 Oct 1;37(19):3717-22. Other studies had shown binding of radioactivity and OSMeO- production to be cytochrome P-450-dependent processes in microsomes and SSMeO- production to result from the action of cytosolic glutathione-S-transferase on OSSMe. |
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| 2769697 | Chambers JE, Forsyth CS: Lack of inducibility of brain monooxygenase activities including parathion desulfuration. J Biochem Toxicol. 1989 Spring;4(1):65-70. Thus, these brain monooxygenase activities appear to be refractory to induction by two classical types of cytochrome P-450 inducers. |
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| 9931232 | Sturm A, Hansen P: Altered cholinesterase and monooxygenase levels in Daphnia magna and Chironomus riparius exposed to environmental pollutants. Ecotoxicol Environ Saf. 1999 Jan;42(1):9-15. These results suggest that cytochrome P450-dependent monooxygenase activities may be useful variables in toxicity tests with aquatic insects. Parathion, dichlorvos, and aldicarb caused dose-related inhibition of cholinesterase (ChE) in 24-h bioassays with both species. |
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| 6766135 | Halpert J, Hammond D, Neal RA: Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate). J Biol Chem. 1980 Feb 10;255(3):1080-9. |
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| 15813 | Yoshihara S, Neal RA: Comparison of the metabolism of parathion by a rat liver reconstituted mixed-function oxidase enzyme system and by a system containing cumene hydroperoxide and purified rat liver cytochrome P-450. Drug Metab Dispos. 1977 Mar-Apr;5(2):191-7. |
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| 3764930 | Sultatos LG: The effects of phenobarbital pretreatment on the metabolism and acute toxicity of the pesticide parathion in the mouse. Toxicol Appl Pharmacol. 1986 Oct;86(1):105-11. Daily pretreatment of mice with phenobarbital (80 mg/kg, ip) for 4 days induced hepatic cytochrome P-450 content, as well as oxidative activation and oxidative detoxification of parathion, as measured in vitro. |
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| 11684353 | Albores A, Ortega-Mantilla G, Sierra-Santoyo A, Cebrian ME, Munoz-Sanchez JL, Calderon-Salinas JV, Manno M: Cytochrome P450 2B (CYP2B)-mediated activation of methyl-parathion in rat brain extracts. Toxicol Lett. 2001 Oct 15;124(1-3):1-10. |
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| 2730675 | Forsyth CS, Chambers JE: Activation and degradation of the phosphorothionate insecticides parathion and EPN by rat brain. Biochem Pharmacol. 1989 May 15;38(10):1597-603. Cytochrome P-450-dependent monooxygenases are known to activate phosphorothionate insecticides to their oxon analogs by oxidative desulfuration. |
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| 1658105 | Chaturvedi AK, Kuntz DJ, Rao NG: Metabolic aspects of the toxicology of mixtures of parathion, toxaphene and/or 2,4-D in mice. J Appl Toxicol. 1991 Aug;11(4):245-51. In general, TOX and TOX-containing mixtures were found to induce the metabolism of amidopyrine (21-52%), (58-72%), phenacetin (239-307%), pentobarbital (104-148%) and benzo [a] pyrene (143-304%) in the 9000 g liver supernatants and to increase the hepatic cytochrome P-450 contents (57-80%). |
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| 6524963 | Purshottam T, Srivastava RK: Effect of high-fat and high-protein diets on toxicity of parathion and dichlorvos. Arch Environ Health. 1984 Nov-Dec;39(6):425-30. Hepatic microsomal cytochrome P-450 and aminopyrine demethylase activity were unchanged, but hydroxylase activity was increased significantly by HPD and HFD. |
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