| Name | CYP2B6 |
|---|---|
| Synonyms | CPB 6; CPB6; CYP2B; CYP2B protein; CYP2B6; CYPIIB 6; CYPIIB6; Cytochrome P450 2B6… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17079358 | Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR: Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos. Drug Metab Dispos. 2007 Feb;35(2):189-93. Epub 2006 Nov 1. CYP2B6 and CYP2C19 demonstrated low K (m) and high V (max) values for the metabolism of both model compounds, which supports their role as the primary enzymes that regulate metabolism at low-level human exposures to OPs. |
2(0,0,0,2) | Details |
| 12620367 | Buratti FM, Volpe MT, Meneguz A, Vittozzi L, Testai E: CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Toxicol Appl Pharmacol. 2003 Feb 1;186(3):143-54. The contribution of CYP2B6 to total hepatic oxon formation was relevant in a wide range of pesticide concentrations, being a very efficient catalyst of both the high- and low-affinity phase. The bioactivation of azinphos-methyl (AZIN), chlorpyrifos (CPF), diazinon (DIA), and parathion (PAR), four widely used organophosphorothioate (OPT) pesticides has been investigated in human liver microsomes (HLM). |
1(0,0,0,1) | Details |
| 10414794 | Mutch E, Blain PG, Williams FM: The role of metabolism in determining susceptibility to parathion toxicity in man. Toxicol Lett. 1999 Jun 30;107(1-3):177-87. |
0(0,0,0,0) | Details |