| Name | choline acetyltransferase |
|---|---|
| Synonyms | CHAT; CHOACTase; CLAT; CMS1A; CMS1A2; ChAT; Choline O acetyltransferase; Choline acetylase… |
| Name | parathion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16675431 | Slotkin TA, Levin ED, Seidler FJ: Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect. 2006 May;114(5):746-51. We contrasted neuritic outgrowth and cholinergic synaptic development in neonatal rats given different organophosphates (chlorpyrifos, diazinon, parathion) at doses spanning the threshold for impaired growth and viability. |
0(0,0,0,0) | Details |
| 940229 | Muramatsu M, Kuriyama K: Effect of organophosphorus compounds on acetylcholine synthesis in brain. . Jpn J Pharmacol. 1976 Apr;26(2):249-54. In addition to well known cholinesterase (ChE) inhibition, parathion showed inhibitory effects on the activity of synaptosomal choline acetyltransferase (ChAc), and on the uptake of [14C-methyl]- and ACHh synthesis in subcellular fractions of the brain. |
81(1,1,1,1) | Details |
| 20015457 | Levin ED, Timofeeva OA, Yang L, Petro A, Ryde IT, Wrench N, Seidler FJ, Slotkin TA: Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. Behav Brain Res. 2010 Apr 2;208(2):319-27. Epub 2009 Dec 17. In association with the effects on cognitive performance, neonatal parathion exposure elicited widespread abnormalities in indices of serotonergic (5HT) and cholinergic synaptic function, characterized by upregulation of 5HT (2) receptors and the 5HT transporter, deficits in choline acetyltransferase activity and nicotinic cholinergic receptors, and increases in hemicholinium-3 binding to the presynaptic choline transporter. |
31(0,1,1,1) | Details |
| 18941570 | Slotkin TA, Bodwell BE, Ryde IT, Levin ED, Seidler FJ: Exposure of neonatal rats to parathion elicits sex-selective impairment of systems in brain regions during adolescence and adulthood. Environ Health Perspect. 2008 Oct;116(10):1308-14. Epub 2008 May 19. METHODS: We assessed neurochemical indices related to the function of synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in brain regions comprising all the major projections, with determinations carried out from adolescence to adulthood (PNDs 30, 60, and 100). |
1(0,0,0,1) | Details |
| 19590683 | Slotkin TA, Lassiter TL, Ryde IT, Wrench N, Levin ED, Seidler FJ: Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on systems in rat brain regions. Environ Health Perspect. 2009 Jun;117(6):916-22. Epub 2009 Feb 3. We assessed three indices of synaptic function: nicotinic receptor binding, choline acetyltransferase activity, and hemicholinium-3 binding. |
1(0,0,0,1) | Details |
| 3975908 | Gupta RC, Rech RH, Lovell KL, Welsch F, Thornburg JE: Brain cholinergic, behavioral, and morphological development in rats exposed in utero to methylparathion. Toxicol Appl Pharmacol. 1985 Mar 15;77(3):405-13. Acetylcholinesterase (AChE) and choline acetyltransferase (CAT) activities, and [3H] quinuclidinyl benzilate (QNB) binding to muscarinic receptors, were determined in several brain regions at 1, 7, 14, 21, and 28 days postnatal age and in maternal brain at Day 19 of gestation. |
1(0,0,0,1) | Details |
| 15019311 | Santos HR, Cintra WM, Aracava Y, Maciel CM, Castro NG, Albuquerque EX: Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon. Neurotoxicology. 2004 Mar;25(3):481-94. The organophosphate cholinesterase (ChE) inhibitor paraoxon is the oxidized active metabolite of parathion, a pesticide whose use in agriculture has been matter of increasing concern. ChE staining decreased in all hippocampal and dentate gyrus regions studied, whereas choline acetyltransferase (ChAT) and zinc-positive fibers remained as in control. |
1(0,0,0,1) | Details |
| 10873710 | Monnet-Tschudi F, Zurich MG, Schilter B, Costa LG, Honegger P: Maturation-dependent effects of chlorpyrifos and parathion and their analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures. Toxicol Appl Pharmacol. 2000 Jun 15;165(3):175-83. Toxic effects, assessed by measuring protein content as an index of general cytotoxicity, and various enzyme activities as cell-type-specific neuronal and glial markers (ChAT and GAD, for cholinergic and GABAergic neurons, respectively, and GS and CNP, for astrocytes and oligodendrocytes, respectively) were only found at more than 70% of AChE inhibition. |
1(0,0,0,1) | Details |
| 9294250 | Scaps P, Demuynck S, Descamps M, Dhainaut A: Effects of organophosphate and pesticides on acetylcholinesterase and choline acetyltransferase activities of the polychaete Nereis diversicolor. Arch Environ Contam Toxicol. 1997 Aug;33(2):203-8. Choline acetyltransferase (ChAT) activity was very low and was not significantly modified by two OP compounds: malathion and parathion-ethyl. |
1(0,0,0,1) | Details |