Protein Information

Name alpha fetoprotein
Synonyms AFP; Alpha fetoprotein; Alpha 1 fetoprotein; Alpha fetoglobulin; Alpha fetoprotein precursor; FETA; HPAFP; Alpha fetoproteins…

Compound Information

Name azobenzene
CAS diphenyldiazene

Reference List

PubMed Abstract RScore(About this table)
2410270 Lamas E, Schweighoffer F, Van Els C, Bachner L, Marie J, Kahn A: Modifications of the expression of liver-specific and non-specific messenger RNAs during azo-dye hepatocarcinogenesis. Eur J Biochem. 1985 Jul 15;150(2):395-9.

The expression of specific and non-specific rat liver messenger RNAs has been studied during 3'-methyl-4-(dimethylamino) azobenzene (3'-MeDAB) carcinogenesis, using cDNA probes complementary to mRNAs encoding aldolase A and B, L-type pyruvate kinase, albumin, alpha-fetoprotein, transferrin and an unidentified 2.7 X 10 (3)-base mRNA. mRNAs specific for undifferentiated cells, such as those encoding aldolase A and the unidentified 2.7 X 10 (3)-base species were re-expressed very early, being easily detectable at the 1st week of 3'-MeDAB treatment.
81(1,1,1,1) Details
6155303 Torii M, Kanai K, Watabe H, Oka H, Oda T: Effect of BCG on hepatocarcinogenesis of the rat induced by 3'-methyl-4-(dimethylamino) azobenzene. Gann. 1980 Feb;71(1):24-9.

After administration of 3'-Me-DAB for 6 weeks, BCG was injected to the rats at 2-week intervals for 50 weeks and the serial determinations of serum alpha-fetoprotein and morphological examination of the liver were made.
2(0,0,0,2) Details
12561433 Fu Y, Deng WG, Li YL, Sugiyama T: [Quantitative analysis of p53 and related genes mRNA in rat hepatocarcinogenesis induced by 3'-Me-DAB]. Ai Zheng. 2003 Jan;22(1):35-41.

In order to find out the alteration in mRNA levels of p53, glutathione S-transferase P (GST-P), alpha-fetoprotein (AFP), and albumin in genesis, developing, and prognosis of hepatocarcinoma, quantitative analysis of mRNA levels of p53, GST-P, AFP, and albumin in prehepatocarcinoma and hepatocarcinoma foci was performed.
METHODS: During hepatocarcinogenesis of F344 rat induced by 3'-methyl-4-dimethylamino-azobenzene (3'-Me-DAB), the levels of these mRNAs were quantitatively analyzed by LightCycler V3 System real-time RT-PCR after capturing accurately micro-foci in prehepatocarcinoma and hepato-carcinoma of rats with laser capture microdissection (LCM).
1(0,0,0,1) Details