Protein Information

Name thrombin
Synonyms Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin…

Compound Information

Name azobenzene
CAS diphenyldiazene

Reference List

PubMed Abstract RScore(About this table)
19359478 Kim Y, Phillips JA, Liu H, Kang H, Tan W: Using photons to manipulate enzyme inhibition by an azobenzene-modified nucleic acid probe. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6489-94. Epub 2009 Apr 9.

Specifically, we positioned azobenzene moieties within the DNA sequence complementary to a 15-base-long thrombin aptamer and then linked the azobenzene-modified cDNA to the aptamer by a polyethylene glycol (PEG) linker to make a unimolecular conjugate.
164(2,2,2,4) Details
3928376 Chang JY, Alkan SS, Hilschmann N, Braun DG: Thrombin specificity. Eur J Biochem. 1985 Sep 2;151(2):225-30.

This knowledge was applied to the selective cleavage of antibody light chains with the aim of producing intact fragments of both variable region and constant region. (a) Mouse kappa light chains 10K26 and 10K44 from anti-(azobenzene arsonate) antibodies contain 20 Arg/Lys-Xaa bonds.
8(0,0,0,8) Details
2836439 Sato M, Shudo K, Hiragun A: Functional studies of newly synthesized benzoic acid derivatives: identification of highly potent retinoid-like activity. J Cell Physiol. 1988 May;135(2):179-88.

Three newly synthesized benzoic acid derivatives (terephthalic acid anilides, chalcone carboxylic acid, and azobenzene carboxylic acid), with a certain structural similarity to retinoic acid, were examined for their retinoid-like bioactivity and their capacity to bind to cellular retinoid binding proteins.
Simultaneous treatment with these compounds and retinoic acid produced only a barely detectable additive effect, suggesting a common mechanism of action, whereas unrelated mitogens, thrombin, and insulin worked synergistically in combination with retinoic acid.
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