| Name | PCNA |
|---|---|
| Synonyms | Cyclin; DNA polymerase delta auxillary protein; PCNA; Proliferating cell nuclear antigen; DNA polymerase delta auxillary proteins; Proliferating cell nuclear antigens |
| Name | azadirachtin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19458912 | Harish Kumar G, Vidya Priyadarsini R, Vinothini G, Vidjaya Letchoumy P, Nagini S: The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis. Invest New Drugs. 2009 May 21. The present study was therefore designed to evaluate the relative chemopreventive potential of the neem limonoids azadirachtin and nimbolide in the hamster buccal pouch (HBP) carcinogenesis model by analyzing the expression of proliferating cell nuclear antigen (PCNA), p21 (waf1), cyclin D1, glutathione S-transferase pi (GST-P), NF-kappaB, inhibitor of kappaB (IkappaB), p53, Fas, Bcl-2, Bax, Bid, Apaf-1, cytochrome C, survivin, caspases-3, -6, -8 and -9, and poly (ADP- polymerase (PARP) by RT-PCR, immunohistochemical, and Western blot analyses. |
31(0,1,1,1) | Details |
| 16652209 | Di Ilio V, Pasquariello N, van der Esch AS, Cristofaro M, Scarsella G, Risuleo G: Cytotoxic and antiproliferative effects induced by a non terpenoid polar extract of A. indica seeds on 3T6 murine fibroblasts in culture. Mol Cell Biochem. 2006 Jul;287(1-2):69-77. Epub 2006 May 2. The anti-proliferative properties of the neem oil-derived compounds were also assayed by evaluation of the nuclear PCNA levels (Proliferating Cell Nuclear Antigen). The most studied component is the terpenoid azadirachtin which is used for its insecticidal and putative antimicrobial properties. |
2(0,0,0,2) | Details |