Protein Information

Name anticholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name phosalone
CAS

Reference List

PubMed Abstract RScore(About this table)
438909 Popendorf WJ, Spear RC, Leffingwell JT, Yager J, Kahn E: Harvester exposure to Zolone (phosalone) residues in peach orchards. 107

Despite estimated dose rates of up to 14 mg/hr, the RBC cholinesterase in these workers may have been only slightly inhibited (circa 4%) when compared to an unexposed, control population.
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8343988 Vasilic Z, Drevenkar V, Stengl B, Frobe Z, Rumenjak V: Diethylphosphorus metabolites in serum and urine of persons poisoned by phosalone. J Wildl Dis. 1990 Jan;26(1):103-6.

The correlation between the maximum concentrations of total metabolites, measured in urine of poisoned persons on the day of admission to hospital or a day later, and the initial depression of serum cholinesterase (EC 3.1.1.8) and erythrocyte acetylcholinesterase (EC 3.1.1.7) activities was poor (r = 0.6).
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9440249 Balasandaram K, Ramalingam K, Selvarajan VR: Bioelectrical activity of brain in Rana tigrina (Daudin) in response to phosalone poisoning. Int J Environ Anal Chem. 1983;14(3):215-30.

The above disturbance in the brain electrical activity may have correlation to the inhibition of cation-linked ATPase, as well as the cholinesterase activity.
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2016649 Ames RG, Mengle DC: Analyzing cholinesterase measurements: assumptions, statistics, and interpretations. J Occup Med. 1991 Feb;33(2):101

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2293466 O'Malley MA, McCurdy SA: Subacute poisoning with phosalone, an organophosphate insecticide. West J Med. 1978 Oct;129(4):273-7.

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2304190 White DH, Seginak JT: Brain cholinesterase inhibition in songbirds from pecan groves sprayed with phosalone and disulfoton. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997 Oct;118(2):229-31.
88(1,1,2,3) Details
16440853 Bharavi K, Reddy KS: Effect of anticholinesterase compound phosalone on blood-brain barrier (BBB) permeability. Indian J Physiol Pharmacol. 2005 Jul-Sep;49(3):337-40.
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6853013 Drevenkar V, Stengl B, Tkalcevic B, Vasilic Z: Occupational exposure control by simultaneous determination of N-methylcarbamates and organophosphorus pesticide residues in human urine. 112.


The level of extracted N-methylcarbamates and the concentration of degradation products of organophosphorus pesticides detected in the urine of the same persons were correlated with the blood and plasma cholinesterase activities.
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538451 Drevenkar V, Frobe Z, Vasilic Z, Tkalcevic B, Stefanac Z: The rate of urinary excretion of phosalone residues in occupationally exposed persons. J Occup Med. 1979 Mar;21(3):189-94.

Blood and plasma cholinesterase activities were only slightly reduced during exposure.
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716389 Peoples SA, Maddy KT: Organophosphate pesticide poisoning. Sci Total Environ. 1979 Dec;13(3):235-43.

Average plasma and red cell cholinesterase values for the affected workers were depressed more than 60 percent.
The exposure to residues of the organophosphate pesticides dialifor (Torak ((R))) and phosalone (Zolone ((R))) occurred in one grower's vineyards near Madera, California.
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