Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name dichlorvos
CAS 2,2-dichloroethenyl dimethyl phosphate

Reference List

PubMed Abstract RScore(About this table)
2026213 O'Leary KA, Tracy JW: Schistosoma mansoni: glutathione S-transferase-catalyzed detoxication of dichlorvos. Exp Parasitol. 1991 May;72(4):355-61.
112(1,2,2,2) Details
2042734 Tracy JW, O'Leary KA: Analysis of glutathione S-transferase-catalyzed S-alkylglutathione formation by high-performance liquid chromatography. Anal Biochem. 1991 Feb 15;193(1):1-5.

The utility of the method is illustrated by the use of partially purified preparations of rat liver glutathione S-transferases and several prototypic substrates including iodomethane, iodoethane, dichlorvos, and methyl parathion.
83(1,1,1,3) Details
14568351 Pena-Llopis S, Ferrando MD, Pena JB: Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine. Aquat Toxicol. 2003 Dec 10;65(4):337-60.

Fish pre-treated with NAC (1 mmol kg (-1), i.p.) and exposed to 1.5 mg l (-1) (the 96-h LC85) of dichlorvos for 96 h in a static-renewal system achieved an increase of the GSH content, GSH/GSSG ratio, hepatic glutathione reductase (GR), glutathione S-transferase (GST), glutamate:cysteine ligase (GCL), and gamma-glutamyl transferase (gammaGT) activities, which ameliorated the glutathione loss and oxidation, and enzyme inactivation, caused by the OP pesticide.
31(0,1,1,1) Details
18539328 Celik I, Suzek H: Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Ecotoxicol Environ Saf. 2009 Mar;72(3):905-8. Epub 2008 Jun 9.

In this study, the effects of dichlorvos (DIC) at sublethal concentration on malondialdehyde (MDA) content and antioxidant defense system (ADS) such as reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in various tissues of rats exposed to 0.0225 and 0.0450 millimole (mmol) DIC in drinking water were administered orally to rats ad libitum for 28 days continuously.
6(0,0,1,1) Details
19140127 Wu S, Dou W, Wu JJ, Wang JJ: Purification and partial characterization of glutathione S-transferase from insecticide-resistant field populations of Liposcelis paeta Pearman (Psocoptera: Liposcelididae). Arch Insect Biochem Physiol. 2009 Feb;70(2):136-50.

These populations were collected from Nanyang city of Henan Province (NY), Wuzhou (WZ) and Hezhou (HZ) cities of Guangxi Province, China, and had different susceptibilities to dichlorvos [LC (50) s of the NY (281.48 mg/m (2)), the WZ (285.07 mg/m (2)), and the HZ (243.52 mg/m (2)), respectively].
2(0,0,0,2) Details
10826201 Jensen SE: Mechanisms associated with methiocarb resistance in Frankliniella occidentalis (Thysanoptera: Thripidae). J Econ Entomol. 2000 Apr;93(2):464-71.

In vitro assays of general esterase, glutathione S-transferase, and acetylcholinesterase activities showed increased activity in some of the resistant populations and increased activity of the enzymes after methiocarb selection on one of the populations.
Assays of acetylcholinesterase sensitivity to inhibition by methiocarb, dichlorvos, and eserine suggested insensitive acetylcholinesterase in two of the resistant populations.
1(0,0,0,1) Details
15568361 Wu G, Jiang S, Miyata T: Seasonal changes of methamidophos susceptibility and biochemical properties in Plutella xylostella (Lepidoptera: Yponomeutidae) and its parasitoid Cotesia plutellae (Hymenoptera: Braconidae). J Econ Entomol. 2004 Oct;97(5):1689-98.

But carboxylesterase activity was 1.6-fold higher in F0 parents of C. plutellae than in F11 progeny, and glutathione S-transferase activity was 1.5-fold higher in F0 parents of P. xylostella than in F11 progeny.
Methamidophos resistance and acetylcholinesterase (AChE) insensitivity to methamidophos, dichlorvos, and carbofuran were determined in the field populations of Plutella xylostella (L.) (Lepidoptera: Yponomeutidae) and its parasitoid Cotesia plutellae Kurdjumov (Hymenoptera: Braconidae) collected from the corresponding hosts between October 1998 and December 2003 in Fuzhou and Minhou, Fijian, China.
1(0,0,0,1) Details