Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name bromopropylate
CAS 1-methylethyl 4-bromo-α-(4-bromophenyl)-α-hydroxybenzeneacetate

Reference List

PubMed Abstract RScore(About this table)
7974489 Thomas H, Sagelsdorff P, Molitor E, Skripsky T, Waechter F: Bromopropylate: induction of hepatic cytochromes P450 and absence of covalent binding to DNA in mouse liver. Toxicol Appl Pharmacol. 1994 Nov;129(1):155-62.

Immunochemical studies with monoclonal antibodies against rat liver cytochrome P450 isoenzymes of the gene families 1A, 2B, 3A, and 4A confirmed that bromopropylate is a phenobarbitone-type inducer in the mouse liver.
7(0,0,1,2) Details
2387028 Flodstrom S, Hemming H, Warngard L, Ahlborg UG: Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides. Carcinogenesis. 1990 Aug;11(8):1413-7.

The organochlorine pesticide 1,1'-(2,2,2-trichloroethylidene) bis (4-chlorobenzene) (DDT) and four structural analogues (bromopropylate, chlorobenzilate, dicofol and fenarimol) were investigated for their ability to inhibit gap junctional intercellular communication both in the Chinese hamster V79 metabolic co-operation assay and in the scrape-loading/dye-transfer assay in WB-F344 rat liver epithelial cells.
1(0,0,0,1) Details