| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | dicofol |
|---|---|
| CAS | 4-chloro-α-(4-chlorophenyl)-α-(trichloromethyl)benzenemethanol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2387028 | Flodstrom S, Hemming H, Warngard L, Ahlborg UG: Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides. Carcinogenesis. 1990 Aug;11(8):1413-7. The organochlorine pesticide 1,1'-(2,2,2-trichloroethylidene) bis (4-chlorobenzene) (DDT) and four structural analogues (bromopropylate, chlorobenzilate, dicofol and fenarimol) were investigated for their ability to inhibit gap junctional intercellular communication both in the Chinese hamster V79 metabolic co-operation assay and in the scrape-loading/dye-transfer assay in WB-F344 rat liver epithelial cells. |
1(0,0,0,1) | Details |
| 11777067 | Stumpf N, Nauen R: Cross-resistance, inheritance, and biochemistry of mitochondrial electron transport inhibitor-acaricide resistance in Tetranychus urticae (Acari: Tetranychidae). J Econ Entomol. 2001 Dec;94(6):1577-83. Furthermore, strain AKITA showed cross-resistance to dicofol. The METI resistant strains AKITA and UK-99 showed 2.4- and 1.7-fold enhanced O-ethoxycoumarin O-deethylation (cytochrome P450) activity. |
1(0,0,0,1) | Details |
| 19595748 | Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH: Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett. 2009 Oct 28;190(2):150-5. Epub 2009 Jul 10. The present study has determined the ability of dicofol, an organochlorine pesticide, to induce cytochrome P450 using rats treated with 1, 10, and 25mg/kg dicofol intraperitoneally for 4 days. |
12(0,0,2,2) | Details |
| 15030474 | Amichot M, Tares S, Brun-Barale A, Arthaud L, Bride JM, Berge JB: Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism. Eur J Biochem. 2004 Apr;271(7):1250-7. The CYP6A2vSVL enzyme had an enhanced metabolism of DDT, producing dicofol, dichlorodiphenyldichloroethane and dichlorodiphenyl |
3(0,0,0,3) | Details |