Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name propoxur
CAS

Reference List

PubMed Abstract RScore(About this table)
6464348 Nelson DL, Lamb DW, Mihail F: A study of liver microsomal enzymes in rats following propoxur (Baygon) administration. Vet Hum Toxicol. 1984 Aug;26(4):305-8.

The activity of aminopyrine-N-demethylase, cytochrome P-450 and p-nitroanisole-O-demethylase in liver homogenates of rats receiving propoxur was measured.
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115523 Neskovic N, Milosevic M, Kljajic R: Cytochrome P-450 content and NADPH-cytochrome c reductase activity in rats treated with carbaryl and propoxur. Bull Environ Contam Toxicol. 1979 Nov;23(4-5):438-44.
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8294621 Hemingway J, Dunbar SJ, Monro AG, Small GJ: Pyrethroid resistance in German cockroaches (Dictyoptera: Blattelidae): resistance levels and underlying mechanisms. J Econ Entomol. 1993 Dec;86(6):1631-8.

Twelve of these strains were also resistant to chlorpyrifos and propoxur.
Possible resistance mechanisms detected in these populations included elevated levels of cytochrome P450, general esterase and glutathione S-transferase, and nerve insensitivity (kdr-type resistance).
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1517505 Siegfried BD, Scott JG: Biochemical characterization of hydrolytic and oxidative enzymes in insecticide resistant and susceptible strains of the German cockroach (Dictyoptera: Blattellidae). J Econ Entomol. 1992 Aug;85(4):1092-8.

We have identified resistance mechanisms in the German cockroach, Blattella germanica (L.), for propoxur and chlorpyrifos in strains of cockroaches that display multiresistance to several organophosphate and carbamate insecticides.
Analysis of components of the cytochrome P450-dependent monooxygenase system and activities toward model substrates indicate that the two resistance mechanisms also involve different oxidative processes.
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17598550 Sims SR, Appel AG: Linear alcohol ethoxylates: insecticidal and synergistic effects on German cockroaches (Blattodea: Blattellidae) and other insects. J Econ Entomol. 2007 Jun;100(3):871-9.

Tomadol 23-1 significantly reduced the insecticidal activity of propoxur, suggesting antagonism.
The insecticidal activity of Tomadol 23-1 was synergized by coapplication with a sublethal amount of piperonyl butoxide, indicating the involvement of cytochrome P450 microsomal monooxygenases in insect metabolism of AEO surfactants.
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2132992 Hemingway J, Callaghan A, Amin AM: Mechanisms of organophosphate and carbamate resistance in Culex quinquefasciatus from Saudi Arabia. Med Vet Entomol. 1990 Jul;4(3):275-82.


The resistance has a metabolic basis and confers cross-resistance against the carbamate propoxur.
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