| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | pyrethrins |
|---|---|
| CAS | pyrethrins |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18381673 | Margaritopoulos JT, Skavdis G, Kalogiannis N, Nikou D, Morou E, Skouras PJ, Tsitsipis JA, Vontas J: Efficacy of the pyrethroid alpha-cypermethrin against Bactrocera oleae populations from Greece, and improved diagnostic for an iAChE mutation. Pest Manag Sci. 2008 Sep;64(9):900-8. Cytochrome P450 monoxygenase activities showed an association with resistance. |
1(0,0,0,1) | Details |
| 16952383 | Yadav S, Johri A, Dhawan A, Seth PK, Parmar D: Regional specificity in deltamethrin induced cytochrome P450 expression in rat brain. Toxicol Appl Pharmacol. 2006 Nov 15;217(1):15-24. Epub 2006 Jul 29. |
1(0,0,0,1) | Details |
| 14527728 | Pridgeon JW, Zhang L, Liu N: Overexpression of CYP4G19 associated with a pyrethroid-resistant strain of the German cockroach, Blattella germanica (L.). Gene. 2003 Sep 18;314:157-63. A new cytochrome P450 gene, CYP4G19, was identified and isolated as a differentially expressed gene between insecticide susceptible ACY and resistant Apyr-R German cockroach strains using PCR-selected subtractive hybridization and cDNA array techniques. |
1(0,0,0,1) | Details |
| 19298862 | He J, Sun H, Zhang D, Sun Y, Ma L, Chen L, Liu Z, Xiong C, Yan G, Zhu C: Cloning and characterization of 60S ribosomal protein L22 (RPL22) from Culex pipiens pallens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Jun;153(2):216-22. Epub 2009 Mar 17. The mRNA level of cytochrome P450 6A1 (CYP6A1, GenBank accession no. |
1(0,0,0,1) | Details |
| 19198521 | Inceoglu AB, Waite TD, Christiansen JA, McAbee RD, Kamita SG, Hammock BD, Cornel AJ: A rapid luminescent assay for measuring cytochrome P450 activity in individual larval Culex pipiens complex mosquitoes (Diptera: Culicidae). J Med Entomol. 2009 Jan;46(1):83-92. |
1(0,0,0,1) | Details |
| 12232873 | Bouvier JC, Boivin T, Beslay D, Sauphanor B: Age-dependent response to insecticides and enzymatic variation in susceptible and resistant codling moth larvae. Arch Insect Biochem Physiol. 2002 Oct;51(2):55-66. The age variation of the activities of cytochrome P450-dependent monooxygenase (MFO), glutathione S-transferases (GST), and esterases in S and both resistant strains were simultaneously investigated. |
1(0,0,0,1) | Details |
| 18508027 | Daaboub J, Ben Cheikh R, Lamari A, Ben Jha I, Feriani M, Boubaker C, Ben Cheikh H: Resistance to pyrethroid insecticides in Culex pipiens pipiens (Diptera: Culicidae) from Tunisia. Acta Trop. 2008 Jul;107(1):30-6. Epub 2008 Apr 22. The use of synergists showed that the cytochrome P450-dependent monooxygenases had a major contribution to the permethrin and deltamethrin resistance and that the esterases (and/or glutathione-S-transferases) had only a minor contribution. |
1(0,0,0,1) | Details |
| 18615616 | Boonsuepsakul S, Luepromchai E, Rongnoparut P: Characterization of Anopheles minimus CYP6AA3 expressed in a recombinant baculovirus system. Arch Insect Biochem Physiol. 2008 Sep;69(1):13-21. We previously isolated the cytochrome P450 CYP6AA3 from deltamethrin-selected resistant strain of Anopheles minimus mosquito, a major malaria vector in Thailand. |
1(0,0,0,1) | Details |
| 17576809 | Godin SJ, Crow JA, Scollon EJ, Hughes MF, DeVito MJ, Ross MK: Identification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate. Drug Metab Dispos. 2007 Sep;35(9):1664-71. Epub 2007 Jun 18. |
1(0,0,0,1) | Details |
| 11976062 | Valles SM, Woodson WD: Insecticide susceptibility and detoxication enzyme activities among Coptotermes formosanus Shiraki workers sampled from different locations in New Orleans. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Apr;131(4):469-76. As with the bioassay data, although significant differences were noted, a great deal of overlap was observed among the colonies for total cytochrome P450 content (difference of 2.2-fold between high and low value) aldrin epoxidation (3.6-fold) and cytosolic esterase (3.9-fold) activity. |
1(0,0,0,1) | Details |
| 12915179 | Martin T, Ochou OG, Vaissayre M, Fournier D: Oxidases responsible for resistance to pyrethroids sensitize Helicoverpa armigera (Hubner) to triazophos in West Africa. Insect Biochem Mol Biol. 2003 Sep;33(9):883-7. Populations recently developed resistance to pyrethroids in West Africa via the overproduction of cytochrome P450 (oxidases) increasing pyrethroid metabolism. |
1(0,0,0,1) | Details |
| 18163524 | Zhu F, Liu N: Differential expression of CYP6A5 and CYP6A5v2 in pyrethroid-resistant house flies, Musca domestica. Arch Insect Biochem Physiol. 2008 Mar;67(3):107-19. Two cytochrome P450 alleles, CYP6A5 and CYP6A5v2, were isolated from a pyrethroid-resistant house fly stain, ALHF. |
1(0,0,0,1) | Details |
| 14585502 | Nikou D, Ranson H, Hemingway J: An adult-specific CYP6 P450 gene is overexpressed in a pyrethroid-resistant strain of the malaria vector, Anopheles gambiae. Gene. 2003 Oct 30;318:91-102. An adult-specific cytochrome P450 monooxygenase 6 (CYP6) P450 gene, CYP6Z1, located within a large cluster of cytochrome P450 genes in chromosome arm 3R of An. gambiae, is expressed approximately 11-fold higher in males and 4.5-fold in females from a pyrethroid-resistant strain than in a susceptible strain from the same geographical area. |
1(0,0,0,1) | Details |
| 12495187 | Rodriguez MM, Bisset J, Ruiz M, Soca A: Cross-resistance to pyrethroid and organophosphorus insecticides induced by selection with temephos in Aedes aegypti (Diptera: Culicidae) from Cuba. J Med Entomol. 2002 Nov;39(6):882-8. Synergism tests implicated detoxifying esterases in temephos and fenthion resistance and deltamethrin resistance was associated with a cytochrome P450 monooxygenasa. |
1(0,0,0,1) | Details |
| 18022748 | Price RJ, Giddings AM, Scott MP, Walters DG, Capen CC, Osimitz TG, Lake BG: Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes. Toxicology. 2008 Jan 14;243(1-2):84-95. Epub 2007 Oct 7. |
12(0,0,2,2) | Details |
| 17084873 | Takeuchi S, Matsuda T, Kobayashi S, Takahashi T, Kojima H: In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma and quantitative analysis of in vivo induction pathway. Toxicol Appl Pharmacol. 2006 Dec 15;217(3):235-44. Epub 2006 Sep 6. To investigate the in vivo effects of diclofop-methyl, pyrethrins and imazalil, we examined the gene expression of PPARalpha-inducible cytochrome P450 4As (CYP4As) in the liver of female mice intraperitoneally injected with these compounds (< or =300 mg/kg). |
6(0,0,1,1) | Details |
| 12567630 | Zhu CL, Li JM, Tian HS, Ma L, Li XL, Wu GL: [Cloning and identification of cytochrome P450 resistance related genes in the mosquito, Culex pipiens pallens]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000;18(5):263-8. |
6(0,0,0,6) | Details |
| 17188729 | Price RJ, Walters DG, Finch JM, Gabriel KL, Capen CC, Osimitz TG, Lake BG: A mode of action for induction of liver tumors by Pyrethrins in the rat. Toxicol Appl Pharmacol. 2007 Jan 15;218(2):186-95. Epub 2006 Nov 11. The treatment of male and female rats with Pyrethrins and NaPB produced significant increases in hepatic microsomal cytochrome P450 (CYP) content and a marked induction of CYP2B-dependent 7-pentoxyresorufin O-depentylase and 16beta-hydroxylase activities. |
6(0,0,1,1) | Details |
| 12542634 | Zhu YC, Snodgrass GL: Cytochrome P450 CYP6X1 cDNAs and mRNA expression levels in three strains of the tarnished plant bug Lygus lineolaris (Heteroptera: Miridae) having different susceptibilities to pyrethroid insecticide. Insect Mol Biol. 2003 Feb;12(1):39-49. |
5(0,0,0,5) | Details |
| 17066813 | Yang Y, Chen S, Wu S, Yue L, Wu Y: Constitutive overexpression of multiple cytochrome P450 genes associated with pyrethroid resistance in Helicoverpa armigera. J Econ Entomol. 2006 Oct;99(5):1784-9. |
4(0,0,0,4) | Details |
| 11428908 | El-Tawil OS, Abdel-Rahman MS: The role of enzyme induction and inhibition on cypermethrin hepatotoxicity. Pharmacol Res. 2001 Jul;44(1):33-40. The role of cytochrome P450 in the hepatotoxicity of cypermethrin insecticide was investigated in fresh hepatocytes isolated either from phenobarbital pretreated rats or control rats and coincubated with SKF525A. |
3(0,0,0,3) | Details |
| 15365239 | Manna S, Bhattacharyya D, Mandal TK, Das S: Repeated dose toxicity of alfa-cypermethrin in rats. J Vet Sci. 2004 Sep;5(3):241-5. Activities of various enzymes, cytochrome P450 and b5 contents in liver, hepatic antioxidant status, tissue residue concentration, haemogram and pathological changes were studied. |
3(0,0,0,3) | Details |
| 11377398 | Heder AF, Hirsch-Ernst KI, Bauer D, Kahl GF, Desel H: Induction of cytochrome P450 2B1 by pyrethroids in primary rat hepatocyte cultures. Biochem Pharmacol. 2001 Jul 1;62(1):71-9. |
2(0,0,0,2) | Details |
| 16169030 | Anand SS, Bruckner JV, Haines WT, Muralidhara S, Fisher JW, Padilla S: Characterization of deltamethrin metabolism by rat plasma and liver microsomes. Toxicol Appl Pharmacol. 2006 Apr 15;212(2):156-66. Epub 2005 Sep 16. While the carboxylesterase metabolism in plasma and liver was characterized using an inhibitor, tetra isopropyl pyrophosphoramide (isoOMPA), CYP450 metabolism was characterized using the cofactor, |
3(0,0,0,3) | Details |
| 11852648 | Park S, Brown TM: Linkage of genes for sodium channel and cytochrome P450 (CYP6B10) in Heliothis virescens. Pest Manag Sci. 2002 Feb;58(2):209-12. |
2(0,0,0,2) | Details |
| 18948380 | Scollon EJ, Starr JM, Godin SJ, DeVito MJ, Hughes MF: In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450 isoforms. Drug Metab Dispos. 2009 Jan;37(1):221-8. Epub 2008 Oct 23. |
2(0,0,0,2) | Details |
| 16859670 | Johri A, Yadav S, Singh RL, Dhawan A, Ali M, Parmar D: Long lasting effects of prenatal exposure to deltamethrin on cerebral and hepatic cytochrome P450s and behavioral activity in rat offspring. Eur J Pharmacol. 2006 Aug 21;544(1-3):58-68. Epub 2006 Jun 27. Prenatal exposure to different doses (0.25, or 0.5 or 1.0 mg/kg corresponding to 1/320 th or 1/160 th or 1/80 th of LD50) of deltamethrin to the pregnant Wistar rats from gestation day 5 to 21 were found to produce a dose dependent increase in the activity of cytochrome P450 (CYP) dependent 7-ethoxyresorufin-O-deethylase (EROD), 7-pentoxyresorufin-O-dealkylase (PROD) and N-nitrosodimethylamine demethylase (NDMA-D) in brain and liver of offspring postnatally at 3 weeks. |
2(0,0,0,2) | Details |
| 14714662 | Rongnoparut P, Boonsuepsakul S, Chareonviriyaphap T, Thanomsing N: Cloning of cytochrome P450, CYP6P5, and CYP6AA2 from Anopheles minimus resistant to deltamethrin. J Vector Ecol. 2003 Dec;28(2):150-8. |
2(0,0,0,2) | Details |
| 12504175 | Dayal M, Parmar D, Dhawan A, Ali M, Dwivedi UN, Seth PK: Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin. Food Chem Toxicol. 2003 Mar;41(3):431-7. |
2(0,0,0,2) | Details |
| 15880260 | Gong MQ, Gu Y, Hu XB, Sun Y, Ma L, Li XL, Sun LX, Sun J, Qian J, Zhu CL: Cloning and overexpression of CYP6F1, a cytochrome P450 gene, from deltamethrin-resistant Culex pipiens pallens. Acta Biochim Biophys Sin. 2005 May;37(5):317-26. |
2(0,0,0,2) | Details |
| 16022326 | Chen S, Yang Y, Wu Y: Correlation between fenvalerate resistance and cytochrome P450-mediated O-demethylation activity in Helicoverpa armigera (Lepidoptera: Noctuidae). J Econ Entomol. 2005 Jun;98(3):943-6. |
2(0,0,0,2) | Details |
| 12144700 | Li X, Berenbaum MR, Schuler MA: Plant allelochemicals differentially regulate Helicoverpa zea cytochrome P450 genes. Insect Mol Biol. 2002 Aug;11(4):343-51. |
2(0,0,0,2) | Details |
| 15273811 | Gonzalez Audino P, Vassena C, Barrios S, Zerba E, Picollo MI: Role of enhanced detoxication in a deltamethrin-resistant population of Triatoma infestans (Hemiptera, Reduviidae) from Argentina. Mem Inst Oswaldo Cruz. 2004 May;99(3):335-9. Epub 2004 Jul 19. Cytochrome p450 mono-oxygenase (p450) activity was measured on individual insects through ethoxycoumarine deethylase (ECOD) activity using a fluorescence microplate reader. |
2(0,0,0,2) | Details |
| 17710279 | Dzul FA, Patricia Penilla R, Rodriguez AD: [Susceptibility and insecticide resistance mechanisms in Anopheles albimanus from the southern Yucatan Peninsula, Mexico]. Salud Publica Mex. 2007 Jul-Aug;49(4):302-11. Biochemical assays showed high levels of glutathione S-transferase (GST), cytochrome P450 and esterases (with pNPA substrate) in all villages. |
2(0,0,0,2) | Details |
| 11455663 | Juliet S, Chakraborty AK, Koley KM, Mandal TK, Bhattacharyya A: Toxico-kinetics, recovery efficiency and microsomal changes following administration of deltamethrin to black Bengal goats. Pest Manag Sci. 2001 Mar;57(3):311-9. A study of the toxico-kinetics, recovery percentage from different substrates, cytotoxicity and role of cytochrome P450 and b5 of liver microsome in the metabolism of deltamethrin were carried out in female black Bengal goat. |
2(0,0,0,2) | Details |
| 17014948 | Muguruma M, Nishimura J, Jin M, Kashida Y, Moto M, Takahashi M, Yokouchi Y, Mitsumori K: Molecular pathological analysis for determining the possible mechanism of piperonyl butoxide-induced hepatocarcinogenesis in mice. Toxicology. 2006 Dec 7;228(2-3):178-87. Epub 2006 Sep 1. Piperonyl butoxide (PBO), alpha-[2-(2-butoxyethoxy) ethoxy]-4,5-methylene-dioxy-2-propyltoluene, is widely used as a synergist for pyrethrins. In the microarray analysis, the expression of oxidative and metabolic stress-related genes--cytochrome P450 (Cyp) 1A1, Cyp2A5 (week 1 only), Cyp2B9, Cyp2B10, and -cytochrome P450 oxidoreductase (Por) was over-expressed in mice given PBO at weeks 1 and 4. |
1(0,0,0,1) | Details |
| 19125173 | Pasay C, Arlian L, Morgan M, Gunning R, Rossiter L, Holt D, Walton S, Beckham S, McCarthy J: The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides. PLoS Negl Trop Dis. 2009;3(1):e354. Epub 2009 Jan 6. Then, to investigate the relative role of specific metabolic pathways inhibited by these synergists, enzyme assays were developed to measure esterase, glutathione S-transferase (GST) and cytochrome P450 monooxygenase (cytochrome P450) activity in mite extracts. |
1(0,0,0,1) | Details |
| 15315820 | Sasabe M, Wen Z, Berenbaum MR, Schuler MA: Molecular analysis of CYP321A1, a novel cytochrome P450 involved in metabolism of plant allelochemicals (furanocoumarins) and insecticides (cypermethrin) in Helicoverpa zea. Gene. 2004 Sep 1;338(2):163-75. |
1(0,0,0,1) | Details |
| 15154513 | Ahmad M, Hollingworth RM: Synergism of insecticides provides evidence of metabolic mechanisms of resistance in the obliquebanded leafroller Choristoneura rosaceana (Lepidoptera: Tortricidae). Pest Manag Sci. 2004 May;60(5):465-73. These studies indicate that enhanced detoxification, often mediated by cytochrome P-450 monooxygenases, but with probable esterase and glutathione S-transferase contributions in some cases, is the major mechanism imparting resistance to different insecticides in C. rosaceana. |
1(0,0,0,1) | Details |
| 12371615 | Varanka Z, Deer KA, Rojik I, Varanka I, Laszlo K, Bartok T, Nemcsok J, Abraham M: Influence of the polyphenolic tannic acid on the toxicity of the insecticide deltametihrin to fish. Acta Biol Hung. 2002;53(3):351-65. Deltamethrin, applied in a very low dose, induced oxyradical production in fish via activation of cytochrome P450 isozymes. |
1(0,0,0,1) | Details |
| 16413821 | Cui Y, Guo J, Xu B, Chen Z: Potential of chlorpyrifos and cypermethrin forming DNA adducts. Mutat Res. 2006 Apr 30;604(1-2):36-41. Epub 2006 Jan 18. However, cypermethrin didn't form DNA interstrand crosslinks on calf thymus DNA and in hepatocytes treated with SKF-525A, a cytochrome P450 inhibitor, which suggests that active metabolites of cypermethrin instead of cypermethrin itself caused DNA interstrand crosslinks and that cytochrome P450 may be involved in the activation of cypermethrin. |
1(0,0,0,1) | Details |
| 19399609 | Brausch JM, Smith PN: Development of resistance to cyfluthrin and naphthalene among Daphnia magna. Ecotoxicology. 2009 Jul;18(5):600-9. Epub 2009 Apr 28. When the cytochrome P450 inhibitor piperonyl butoxide was used in conjunction with cyfluthrin and naphthalene the sensitivity of resistant and control D. magna were equal, suggesting P450s were responsible for conveying resistance. |
1(0,0,0,1) | Details |
| 16494911 | Johri A, Dhawan A, Lakhan Singh R, Parmar D: Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):279-89. Epub 2006 Feb 21. Prenatal exposure to low doses (0.25 or 0.5 or 1.0 mg/kg, p.o.) of deltamethrin, a type II pyrethroid insecticide, to pregnant dams from gestation days 5 to 21 (GD5-21) produced dose-dependent alterations in the ontogeny of xenobiotic metabolizing cytochrome P450 (CYP) isoforms in brain and liver of the offsprings. |
1(0,0,0,1) | Details |
| 17257205 | Grubor VD, Heckel DG: Evaluation of the role of CYP6B cytochrome P450s in pyrethroid resistant Australian Helicoverpa armigera. Insect Mol Biol. 2007 Feb;16(1):15-23. In evaluating the cytochrome P450 genes CYP6B7, CYP6B6, and CYP6B2 as candidates for RFen1, we found that they occur in a tandem array in the genome, next to the gene encoding the para-type sodium channel; the target of pyrethroid insecticides. |
1(0,0,0,1) | Details |
| 19176366 | Deguchi Y, Yamada T, Hirose Y, Nagahori H, Kushida M, Sumida K, Sukata T, Tomigahara Y, Nishioka K, Uwagawa S, Kawamura S, Okuno Y: Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation. Toxicol Sci. 2009 Mar;108(1):69-80. Epub 2009 Jan 27. To understand the mode of action (MOA) by which the tumors are produced, a series of studies examined the effects of Metofluthrin on hepatic microsomal cytochrome P450 (CYP) content, hepatocellular proliferation, hepatic gap junctional intercellular communication (GJIC), oxidative stress and apoptosis was conducted after one or two weeks of treatment. |
1(0,0,0,1) | Details |
| 18179425 | Muller P, Chouaibou M, Pignatelli P, Etang J, Walker ED, Donnelly MJ, Simard F, Ranson H: Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon. Mol Ecol. 2008 Feb;17(4):1145-55. Epub 2007 Dec 20. Several genes with antioxidant roles, including superoxide dismutases, a glutathione S-transferase and a thioredoxin-dependent peroxidase, and a cytochrome P450 showed elevated expression in mosquito families collected during the insecticide-spraying programme. |
1(0,0,0,1) | Details |
| 17484068 | Fang XK, Huang DF, Wang ZX, Wan CL, Sun T, Xu WJ, Liu CY, Zhou P, Qiao ZD: Identification of the proteins related to cytochrome P450 induced by fenvalerate in a Trichoplusia ni cell line. Cell Biol Toxicol. 2007 Nov;23(6):445-57. Epub 2007 May 7. |
1(0,0,0,1) | Details |
| 11777067 | Stumpf N, Nauen R: Cross-resistance, inheritance, and biochemistry of mitochondrial electron transport inhibitor-acaricide resistance in Tetranychus urticae (Acari: Tetranychidae). J Econ Entomol. 2001 Dec;94(6):1577-83. The METI resistant strains AKITA and UK-99 showed 2.4- and 1.7-fold enhanced O-ethoxycoumarin O-deethylation (cytochrome P450) activity. |
1(0,0,0,1) | Details |
| 11233122 | Kranthi KR, Jadhav D, Wanjari R, Kranthi S, Russell D: Pyrethroid resistance and mechanisms of resistance in field strains of Helicoverpa armigera (Lepidoptera: Noctuidae). J Econ Entomol. 2001 Feb;94(1):253-63. Studies carried out through estimation of detoxification enzyme activity and synergists indicated that enhanced cytochrome p450 and esterase activities were probably important mechanisms for pyrethroid resistance in field strains. |
1(0,0,0,1) | Details |
| 18237281 | Amenya DA, Naguran R, Lo TC, Ranson H, Spillings BL, Wood OR, Brooke BD, Coetzee M, Koekemoer LL: Over expression of a cytochrome P450 (CYP6P9) in a major African malaria vector, Anopheles Funestus, resistant to pyrethroids. Insect Mol Biol. 2008 Feb;17(1):19-25. |
1(0,0,0,1) | Details |
| 11948970 | Kumar S, Thomas A, Sahgal A, Verma A, Samuel T, Pillai MK: Effect of the synergist, piperonyl butoxide, on the development of deltamethrin resistance in yellow fever mosquito, Aedes aegypti L. (Diptera: Culicidae). Arch Insect Biochem Physiol. 2002 May;50(1):1-8. The data indicate the involvement of cytochrome P450-dependent detoxification as the primary mechanism of development of resistance to deltamethrin in the larvae. |
1(0,0,0,1) | Details |
| 15825765 | Rodpradit P, Boonsuepsakul S, Chareonviriyaphap T, Bangs MJ, Rongnoparut P: Cytochrome P450 genes: molecular cloning and overexpression in a pyrethroid-resistant strain of Anopheles minimus mosquito. J Am Mosq Control Assoc. 2005 Mar;21(1):71-9. |
1(0,0,0,1) | Details |
| 19610439 | Ramoutar D, Cowles RS, Alm SR: Pyrethroid resistance mediated by enzyme detoxification in Listronotus maculicollis (Coleoptera: Curculionidae) from Connecticut. J Econ Entomol. 2009 Jun;102(3):1203-8. In this study, topical application bioassays with bifenthrin and bifenthrin combined with synergists affecting three detoxification systems were conducted on four field-collected adult populations of L. maculicollis from Connecticut to determined whether cytochrome P450 monooxgenases (P450s), glutathione S-transferases (GSTs), and/or carboxyl-esterases (COEs) mediated metabolic detoxification. |
1(0,0,0,1) | Details |
| 16831841 | Mirfazaelian A, Kim KB, Anand SS, Kim HJ, Tornero-Velez R, Bruckner JV, Fisher JW: Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague-Dawley rat. Toxicol Sci. 2006 Oct;93(2):432-42. Epub 2006 Jul 10. Cytochrome P450-mediated metabolism was accounted for in the liver and carboxylesterase (CaE)-mediated metabolism in plasma and liver. |
1(0,0,0,1) | Details |
| 19326768 | Das PC, Streit TM, Cao Y, Rose RL, Cherrington N, Ross MK, Wallace AD, Hodgson E: Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36. Pyrethroids are known to be capable of inducing cytochrome P450 (CYP) 2B1/2B2, CYP1A1 and overall CYP content in rat liver. |
1(0,0,0,1) | Details |