Protein Information

Name androgen receptor
Synonyms AIS; AR; Androgen receptor; DHTR; Dihydrotestosterone receptor; HUMARA; KD; NR3C4…

Compound Information

Name pyrethrins
CAS pyrethrins

Reference List

PubMed Abstract RScore(About this table)
16125883 Xu LC, Sun H, Chen JF, Bian Q, Song L, Wang XR: Androgen receptor activities of p,p'-DDE, fenvalerate and phoxim detected by androgen receptor reporter gene assay. Toxicol Lett. 2006 Jan 5;160(2):151-7. Epub 2005 Aug 25.

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16621434 Kim HJ, Park YI, Dong MS: Comparison of prostate cancer cell lines for androgen receptor-mediated reporter gene assays. Toxicol In Vitro. 2006 Oct;20(7):1159-67. Epub 2006 Mar 8.

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12711008 Hartel A, Didier A, Pfaffl MW, Meyer HH: Characterisation of gene expression patterns in 22RV1 cells for determination of environmental androgenic/antiandrogenic compounds. J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):231-8.


Alteration of androgen receptor function due to hormonally active compounds in the environment, may be responsible for impaired reproductive function in aquatic wildlife.
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16857237 Sun H, Xu XL, Xu LC, Song L, Hong X, Chen JF, Cui LB, Wang XR: Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay. Chemosphere. 2007 Jan;66(3):474-9. Epub 2006 Jul 20.


We tested three frequently encountered pyrethroids (fenvalerate, cypermethrin, permethrin) and their metabolite 3-phenoxybenzoic acid (3-PBA) for antiandrogenic and androgenic activity using a human androgen receptor (AR) mediated luciferase reporter gene assay in CV-1 African green monkey kidney cell.
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12628315 Yamada T, Ueda S, Yoshioka K, Kawamura S, Seki T, Okuno Y, Mikami N: Lack of estrogenic or (anti-) androgenic effects of d-phenothrin in the uterotrophic and Hershberger assays. Toxicology. 2003 Apr 22;186(3):227-39.


Recently, d-phenothrin, a synthetic pyrethroid, is suspected to have endocrine activities through the estrogen and androgen receptors.
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12052007 Kunimatsu T, Yamada T, Ose K, Sunami O, Kamita Y, Okuno Y, Seki T, Nakatsuka I: Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays. Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 1):227-37.


In the present study, we evaluated the interaction of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) with androgen receptor (AR)- and estrogen receptor (ER)-mediated mechanisms using in vivo short-term assays.
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18586453 Zhang J, Zhu W, Zheng Y, Yang J, Zhu X: The antiandrogenic activity of pyrethroid pesticides cyfluthrin and beta-cyfluthrin. Reprod Toxicol. 2008 Aug;25(4):491-6. Epub 2008 May 15.


A stably transfected, androgen-responsive cell line, MDA-kb2, was used to determine the androgen receptor (AR) antagonistic effects of cyfluthrin and beta-cyfluthrin in vitro, and the Hershberger assay was utilized to detect the antiandrogenic potential of the two pyrethroids in vivo.
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