| 17483257 |
Trefzer A, Jungmann V, Molnar I, Botejue A, Buckel D, Frey G, Hill DS, Jorg M, Ligon JM, Mason D, Moore D, Pachlatko JP, Richardson TH, Spangenberg P, Wall MA, Zirkle R, Stege JT: Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. Appl Environ Microbiol. 2007 Jul;73(13):4317-25. Epub 2007 May 4.
Discovery of the CYP107Z subfamily of cytochrome P450 oxidases (CYPs) led to an alternative biocatalytic synthesis of 4''-oxo-avermectin, a key intermediate for the commercial production of the semisynthetic insecticide emamectin. |
31(0,1,1,1) |
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| 17073793 |
Molnar I, Jungmann V, Stege J, Trefzer A, Pachlatko JP: Biocatalytic conversion of avermectin into 4''-oxo-avermectin: discovery, characterization, heterologous expression and specificity improvement of the cytochrome P450 enzyme. Biochem Soc Trans. 2006 Dec;34(Pt 6):1236-40.
4''-Oxo-avermectin is a key intermediate in the manufacture of the insecticide emamectin benzoate from the natural product avermectin. |
2(0,0,0,2) |
Details |