| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | simazine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10222312 | Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M: In vitro metabolism of chlorotriazines: characterization of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers. Toxicol Appl Pharmacol. 1999 May 1;156(3):195-205. |
82(1,1,1,2) | Details |
| 10647908 | Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M: In vitro metabolism of simazine, atrazine and propazine by hepatic cytochrome P450 enzymes of rat, mouse and guinea pig, and oestrogenic activity of chlorotriazines and their main metabolites. Xenobiotica. 1999 Dec;29(12):1213-26. |
32(0,1,1,2) | Details |
| 17193734 | Gunasekara AS, Troiano J, Goh KS, Tjeerdema RS: Chemistry and fate of simazine. . Rev Environ Contam Toxicol. 2007;189:1-23. Metabolism of simazine in higher organisms is via cytochrome P-450-mediated oxidation and conjugation. |
31(0,1,1,1) | Details |
| 9711812 | Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M: Changes in rat liver cytochrome P450 enzymes by atrazine and simazine treatment. Xenobiotica. 1998 Jul;28(7):683-98. |
12(0,0,2,2) | Details |
| 8593046 | Shao ZQ, Behki R: Characterization of the expression of the thcB gene, coding for a pesticide-degrading cytochrome P-450 in Rhodococcus strains. Appl Environ Microbiol. 1996 Feb;62(2):403-7. Atrazine, simazine, or carbofuran, although metabolized by the system, had no effect on the thcB-lacZ expression. |
3(0,0,0,3) | Details |
| 8284829 | Snoz SV, Dmitrenko NP: [N-demethylation and denitrosation activity of the rat liver, thymus lymphocytes and spleen after exposure to simazine and Ukr Biokhim Zh. 1993 Jul-Aug;65(4):94-8. Simazine and NaNO2 have been studied for their effect on cytochrome P-450-binding N-demethylation and denitrosation activity in the rat liver and lymphocytes in the subchronic (two-month-long) experiment. |
31(0,1,1,1) | Details |
| 10746939 | Sanderson JT, Seinen W, Giesy JP, van den Berg M: 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?. Toxicol Sci. 2000 Mar;54(1):121-7. Our laboratory is using the human H295R adrenocortical carcinoma cell line to examine chemicals for their potential to interfere with the activity and/or expression of several key cytochrome P450 (CYP) enzymes involved in the biosynthesis of steroid hormones. In this report we demonstrated that the commonly used 2-chloro-s-triazine herbicides atrazine, simazine, and propazine dose-dependently (0-30 microM) induced aromatase (CYP19) activity to an apparent maximum of about 2.5-fold in H295R cells. |
1(0,0,0,1) | Details |
| 15788727 | Vinggaard AM, Christiansen S, Laier P, Poulsen ME, Breinholt V, Jarfelt K, Jacobsen H, Dalgaard M, Nellemann C, Hass U: Perinatal exposure to the fungicide prochloraz feminizes the male rat offspring. Toxicol Sci. 2005 Jun;85(2):886-97. Epub 2005 Mar 23. In addition cytochrome P450 (CYP) 1A activities in livers were induced by prochloraz, possibly as a result of Ah receptor activation. The purpose of this study was to investigate reproductive toxic effects after exposure during gestation and lactation to prochloraz alone and a mixture of five pesticides (deltamethrin, methiocarb, prochloraz, simazine, and tribenuron-methyl). |
1(0,0,0,1) | Details |
| 16248553 | Kawahigashi H, Hirose S, Ohkawa H, Ohkawa Y: Transgenic rice plants expressing human CYP1A1 remediate the triazine herbicides atrazine and simazine. J Agric Food Chem. 2005 Nov 2;53(22):8557-64. The human cytochrome P450 CYP1A1 gene was introduced into rice plants (Oryza sativa cv. |
1(0,0,0,1) | Details |