Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name carvone
CAS 2-methyl-5-(1-methylethenyl)-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
6285897 Dreesen TD, Koch RB: Odorous chemical perturbations of (Na+ + K+)-dependent ATPase activities. Biochem J. 1982 Apr 1;203(1):69-75.

Individual turbinals from the right and left sides of dog olfactory tissue were removed and nerve-ending-particle preparations were prepared. (Na+ + K+)-dependent ATPase activities of the individual preparations, and the effect of several odorous compounds [including (+)- and (-)-carvone] on the (Na+ + K+)-dependent ATPase activities, were determined.
9(0,0,1,4) Details
16250659 Sohoel H, Liljefors T, Ley SV, Oliver SF, Antonello A, Smith MD, Olsen CE, Isaacs JT, Christensen SB: Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin. J Med Chem. 2005 Nov 3;48(22):7005-11.

The two inhibitors were synthesized using (S)-carvone as starting material and found to be 3 and 10 times more potent than thapsigargin.
2(0,0,0,2) Details