| Name | vanilloid receptor 1 |
|---|---|
| Synonyms | Capsaicin receptor; OTRPC 1; Osm 9 like TRP channel 1; TRP vanilloid 1; TRPV 1; TRPV1; Transient receptor potential cation channel subfamily V member 1… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17720863 | Li HY, Park CK, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB: Eugenol inhibits K+ currents in trigeminal ganglion neurons. . J Dent Res. 2007 Sep;86(9):898-902. Eugenol inhibits voltage-activated Na (+) and Ca (2+) channels in a transient receptor potential vanilloid 1 (TRPV1)-independent manner. |
163(2,2,2,3) | Details |
| 19376653 | Park CK, Kim K, Jung SJ, Kim MJ, Ahn DK, Hong SD, Kim JS, Oh SB: Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system. Pain. 2009 Jul;144(1-2):84-94. Epub 2009 Apr 18. At cellular level, eugenol reversibly inhibited APs and VGSCs in IB (4)+/TRPV1+/Na (v) 1.8+ nociceptive TG neurons (Type I-Type III) and IB (4)-/TRPV1-/Na (v) 1.8- nociceptive TG neurons (Type IV). |
113(1,2,2,3) | Details |
| 14514756 | Yang BH, Piao ZG, Kim YB, Lee CH, Lee JK, Park K, Kim JS, Oh SB: Activation of vanilloid receptor 1 (VR1) by eugenol. . J Dent Res. 2003 Oct;82(10):781-5. |
112(1,2,2,2) | Details |
| 19967073 | Li HY, Lee BK, Kim JS, Jung SJ, Oh SB: Eugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons. . Korean J Physiol Pharmacol. 2008 Dec;12(6):315-21. Epub 2008 Dec 31. We suggest, therefore, that eugenol inhibits P2X (3) currents in a TRPV1-independent manner, which contributes to its analgesic effect. |
81(1,1,1,1) | Details |
| 20152883 | Moreira-Lobo DC, Linhares-Siqueira ED, Cruz GM, Cruz JS, Carvalho-de-Souza JL, Lahlou S, Coelho-de-Souza AN, Barbosa R, Magalhaes PJ, Leal-Cardoso JH: Eugenol modifies the excitability of rat sciatic nerve and superior cervical ganglion neurons. Neurosci Lett. 2010 Mar 26;472(3):220-4. Epub 2010 Feb 10. Eugenol possesses analgesic effects that may be related to the inhibition of voltage-dependent Na+ channels and/or to the activation of TRPV1 receptors or both. |
81(1,1,1,1) | Details |
| 9372790 | Ohkubo T, Kitamura K: Eugenol activates Ca (2+)-permeable currents in rat dorsal root ganglion cells. J Dent Res. 1997 Nov;76(11):1737-44. Our results suggest that eugenol activates a Ca (2+)-permeable ion channel in rat DRG neurons through two different mechanisms: a capsaicin receptor-mediated pathway and a pathway independent of the capsaicin-receptor. |
81(1,1,1,1) | Details |
| 16998128 | Park CK, Li HY, Yeon KY, Jung SJ, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB: Eugenol inhibits currents in dental afferent neurons. . J Dent Res. 2006 Oct;85(10):900-4. Our results demonstrated that eugenol inhibits I (Na) in a TRPV1-independent manner. |
81(1,1,1,1) | Details |
| 9126180 | Ohkubo T, Shibata M: The selective antagonist capsazepine abolishes the antinociceptive action of eugenol and J Dent Res. 1997 Apr;76(4):848-51. These results suggest that eugenol and may exert their antinociceptive effects via the capsaicin receptor located on sensory terminals in the spinal cord. |
6(0,0,1,1) | Details |
| 18218839 | Chung G, Rhee JN, Jung SJ, Kim JS, Oh SB: Modulation of CaV2.3 calcium channel currents by eugenol. . J Dent Res. 2008 Feb;87(2):137-41. In contrast, TRPV1 activation is prerequisite for the inhibition of Ca (V) 2.3 channels by |
1(0,0,0,1) | Details |
| 16109996 | Lee MH, Yeon KY, Park CK, Li HY, Fang Z, Kim MS, Choi SY, Lee SJ, Lee S, Park K, Lee JH, Kim JS, Oh SB: Eugenol inhibits currents in dental afferent neurons. . J Dent Res. 2005 Sep;84(9):848-51. Abbreviations: high-voltage-activated calcium channel, HVACC; transient receptor potential vanilloid 1, TRPV1; trigeminal ganglion, TG; dorsal root ganglion, DRG; capsazepine, CZP. |
1(0,0,0,1) | Details |
| 18824159 | Cho JS, Kim TH, Lim JM, Song JH: Effects of eugenol on Na+ currents in rat dorsal root ganglion neurons. . Brain Res. 2008 Dec 3;1243:53-62. Epub 2008 Sep 19. It also regulates ion channels involved in pain signaling, such as TRPV1 receptor, high-voltage-activated Ca (2+) channels, NMDA receptor and (A) receptor. |
1(0,0,0,1) | Details |
| 18543354 | Morsy MA, Fouad AA: Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother Res. 2008 Oct;22(10):1361-6. |
0(0,0,0,0) | Details |