Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
16828188 Gill AO, Holley RA: Inhibition of membrane bound ATPases of Escherichia coli and Listeria monocytogenes by plant oil aromatics. Int J Food Microbiol. 2006 Sep 1;111(2):170-4. Epub 2006 Jul 7.

L. monocytogenes ATPase activity was significantly inhibited by eugenol (5 or 10 mM), carvacrol (10 mM) and cinnamaldehyde (10 mM).
113(1,2,2,3) Details
12929725 Usta J, Kreydiyyeh S, Barnabe P, Bou-Moughlabay Y, Nakkash-Chmaisse H: Comparative study on the effect of cinnamon and clove extracts and their main components on different types of ATPases. Hum Exp Toxicol. 2003 Jul;22(7):355-62.

The 50% inhibition of the CPx-type Cu2+ ATPase was obtained at 0.94 mM for cinnamaldehyde and 0.65 mM for eugenol.
33(0,1,1,3) Details
16417936 Gill AO, Holley RA: Disruption of Escherichia coli, Listeria monocytogenes and Lactobacillus sakei cellular membranes by plant oil aromatics. Int J Food Microbiol. 2006 Apr 15;108(1):1-9. Epub 2006 Jan 18.

The release of ATP from eugenol and carvacrol-treated cells and absence of release from cinnamaldehyde-treated cells could indicate that eugenol and carvacrol possess ATPase inhibiting activity.
31(0,1,1,1) Details
10930696 Kreydiyyeh SI, Usta J, Copti R: Effect of cinnamon, clove and some of their constituents on the Na (+)-K (+)-ATPase activity and alanine absorption in the rat jejunum. Food Chem Toxicol. 2000 Sep;38(9):755-62.

The IC (50) values of eugenol, aqueous clove extract and ethanolic clove extract all fell within the same range and were not significantly different from each other, suggesting that eugenol is the major inhibitory component in both alcoholic and aqueous extracts.
6(0,0,0,6) Details
15550789 Damiani CE, Moreira CM, Zhang HT, Creazzo TL, Vassallo DV: Effects of eugenol, an essential oil, on the mechanical and electrical activities of cardiac muscle. J Cardiovasc Pharmacol. 2004 Dec;44(6):688-95.

We investigated inotropic effects of EUG in rat left ventricular papillary muscles, measuring isometric force, time variables, and post rest potentiation and EUG actions on the effects of Ca2+ (0.62 to 2.5 mM) and isoproterenol (5 ng/ml), on myosin ATPase activity and on the calcium currents in single ventricular myocytes.
1(0,0,0,1) Details
12065215 Usta J, Kreydiyyeh S, Bajakian K, Nakkash-Chmaisse H: In vitro effect of eugenol and cinnamaldehyde on membrane potential and respiratory chain complexes in isolated rat liver mitochondria. Food Chem Toxicol. 2002 Jul;40(7):935-40.

0(0,0,0,0) Details