| Name | IL 1beta |
|---|---|
| Synonyms | Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17509409 | Lee YY, Hung SL, Pai SF, Lee YH, Yang SF: Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages. J Endod. 2007 Jun;33(6):698-702. Epub 2007 Apr 2. Eugenol was shown to block the release of the bone resorbing mediators, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and from LPS-stimulated macrophages. |
162(2,2,2,2) | Details |
| 12029496 | De Smedt AC, Van Den Heuvel RL, Van Tendeloo VF, Berneman ZN, Schoeters GE, Weber E, Tuschl H: Phenotypic alterations and IL-1beta production in CD34 (+) progenitor- and monocyte-derived dendritic cells after exposure to allergens: a comparative analysis. Arch Dermatol Res. 2002 May;294(3):109-16. Epub 2002 Apr 9. The aim of this study was to determine the state of maturation/activation of both populations after exposure to several concentrations of four well-established model allergens eugenol, alpha-hexylcinnamaldehyde and 2,4,6-trinitrobenzene or the irritant |
3(0,0,0,3) | Details |
| 19296372 | Rodrigues TG, Fernandes A Jr, Sousa JP, Bastos JK, Sforcin JM: In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. Nat Prod Res. 2009;23(4):319-26. This work was aimed to investigate the effect in vivo of a water-soluble part of hydroalcoholic extract of clove on pro-inflammatory cytokines (IL-1beta and IL-6) production by macrophages of BALB/c mice. Eugenol was found to be the major component of the clove extract and essential oil, and probably is the causative agent of cytokine inhibition. |
2(0,0,0,2) | Details |
| 11566557 | Tuschl H, Kovac R: Langerhans cells and immature dendritic cells as model systems for screening of skin sensitizers. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):327-31. The sensitizers NiSO (4), dinitrochlorobenzene, 2,4,6-trinitrobenzene alpha-hexylcinnamaldehyde and eugenol were applied. Both the expression of surface markers and the induction of intracellular interleukin-1 beta (IL-1 beta) were analyzed. |
1(0,0,0,1) | Details |
| 12789158 | Haglund R, He J, Jarvis J, Safavi KE, Spangberg LS, Zhu Q: Effects of root-end filling materials on fibroblasts and macrophages in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Jun;95(6):739-45. CONCLUSION: All root-end filling materials inhibited cell growth, and none induced IL-1beta and IL-6 production. |
1(0,0,0,1) | Details |
| 19671757 | Koeberle A, Northoff H, Werz O: blocks biosynthesis through direct inhibition of the microsomal synthase-1. Mol Cancer Ther. 2009 Aug;8(8):2348-55. Epub 2009 Aug 11. reversibly inhibited the conversion of PGH (2) to PGE (2) by microsomal PGE (2) synthase-1 in microsomes of interleukin-1beta-stimulated A549 lung carcinoma cells with an IC (50) of 0.2 to 0.3 micromol/L. Closely related polyphenols (e.g., coniferyl eugenol, failed in this respect, and isolated ovine COX-1 and human recombinant COX-2 were not inhibited by up to 30 micromol/L. |
1(0,0,0,1) | Details |
| 9759017 | Koh ET, McDonald F, Pitt Ford TR, Torabinejad M: Cellular response to Mineral Trioxide Aggregate. J Endod. 1998 Aug;24(8):543-7. Media were removed for ELISA analysis of interleukin (IL)-1 alpha, IL-1 beta, IL-6, and macrophage colony-stimulating factor. |
1(0,0,0,1) | Details |
| 15585374 | Verheyen GR, Schoeters E, Nuijten JM, Van Den Heuvel RL, Nelissen I, Witters H, Van Tendeloo VF, Berneman ZN, Schoeters GE: Cytokine transcript profiling in CD34+-progenitor derived dendritic cells exposed to contact allergens and irritants. Toxicol Lett. 2005 Jan 15;155(1):187-94. We here investigated wether genes encoding the interleukins IL-1beta, IL-6 and IL-8, and the chemokines CCL2, CCL3, CCL3L1 and CCL4 are useful markers for sensitization testing in CD34+-progenitor derived dendritic cells (CD34-DC). CD34-DC from at least three donors were exposed during 0.5 up to 24h to the chemical sensitizers sulphate, oxazolone, 2,4-dinitrochlorobenzene (DNCB) and eugenol, and to the irritants (SDS) and benzalkonium sulphate (BC). mRNA expression was evaluated using real-time RT-PCR. |
1(0,0,0,1) | Details |
| 17118622 | Miyazawa M, Ito Y, Yoshida Y, Sakaguchi H, Suzuki H: Phenotypic alterations and cytokine production in THP-1 cells in response to allergens. Toxicol In Vitro. 2007 Apr;21(3):428-37. Epub 2006 Oct 14. Indeed, all tested allergens, except eugenol (EU), caused significant increased changes in at least four of the analyzed six markers, while non-allergens did not induce any changes. At the same time, we have also reported that augmented expression of HLA and CD80, and production of IL-1beta were up-regulated in THP-1 cells when treated with an allergen, 2,4-dinitrochlorobenzene (DNCB). |
1(0,0,0,1) | Details |
| 9772097 | Corsini E, Primavera A, Marinovich M, Galli CL: Selective induction of cell-associated interleukin-1alpha in murine keratinocytes by chemical allergens. Toxicology. 1998 Aug 21;129(2-3):193-200. In the mouse only, it has been demonstrated by other, that contact sensitizers up-regulated keratinocytes-derived interleukin-1alpha (IL-1), macrophage inflammatory protein-2 and interferon induced protein 10 mRNAs. We investigated the effects of five relevant skin allergens (dinitrochlorobenzene, oxazolone, penicillin G and eugenol), two skin irritants (benzalkonium and methylsalicilate) and two compounds with no sensitizing activity and on IL-1 production in HEL30 cells. |
4(0,0,0,4) | Details |