Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name dimethyl phthalate
CAS dimethyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
7115078 Walseth F, Toftgard R, Nilsen OG: Phthalate esters I: Effects on cytochrome P-450 mediated metabolism in rat liver and lung, serum enzymatic activities and serum protein levels. Arch Toxicol. 1982 May;50(1):1-10.

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6754361 Seth PK: Hepatic effects of phthalate esters. Environ Health Perspect. 1982 Nov;45:27-34.

DEHP produced a time- and route-dependent effect on the hepatic cytochrome P-450 contents and activity of aminopyrine N-demethylase, aniline hydroxylase, alcohol dehydrogenase and high and low Km aldehyde dehydrogenases when given orally or intraperitoneally.
Activity of aminopyrine N-demethylase and aniline hydroxylase was also inhibited by dimethyl phthalate (DMP) and dibutyl phthalate (DBP) after a single oral administration.
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