Protein Information

Name acetylcholine receptors (protein family or complex)
Synonyms Acetylcholine receptor; Acetylcholine receptors

Compound Information

Name aldicarb
CAS

Reference List

PubMed Abstract RScore(About this table)
14644616 Smulders CJ, Bueters TJ, Van Kleef RG, Vijverberg HP: Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase. Toxicol Appl Pharmacol. 2003 Dec 1;193(2):139-46.

The potency order of six carbamates to inhibit alpha4beta4 nicotinic receptors is fenoxycarb > EPTC > carbaryl, bendiocarb > propoxur > aldicarb with IC50 values ranging from 3 microM for fenoxycarb to 165 microM for propoxur and > 1 mM for aldicarb.
3(0,0,0,3) Details
3508476 Mansour NA, Valdes JJ, Shamoo AE, Annau Z: Biochemical interactions of carbamates and ecothiophate with the activated conformation of nicotinic acetylcholine receptor. J Biochem Toxicol. 1987 Spring;2:25-42.

While we observed a high potency of Neo and Physo in inhibiting [125-I]-alpha-BGT binding, it was undetectable for the carbamate insecticide 2-methyl-2-(methylthio) propionaldehyde-O-(methylcarbamoyl) oxime (aldicarb).
2(0,0,0,2) Details
3822252 Bakry NM, Sherby SM, Eldefrawi AT, Eldefrawi ME: Oxadiazolidinones: irreversible inhibition of cholinesterases and effects on acetylcholine receptors. Neurotoxicology. 1986 Fall;7(3):1-10.

Aldicarb, a carbamate anticholinesterase, which protected Torpedo AChE against irreversible phosphorylation by DFP, also protected it against irreversible inhibition by DBOX and MPOX.
1(0,0,0,1) Details
12954868 Bany IA, Dong MQ, Koelle MR: Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior. J Neurosci. 2003 Sep 3;23(22):8060-9.


In addition, increasing synaptic acetylcholine by reducing acetylcholinesterase activity, with either mutations or the inhibitor aldicarb, decreased egg laying.
0(0,0,0,0) Details