Protein Information

Name gamma glutamyl transferase
Synonyms CD224; CD224 antigen; D22S672; D22S732; GGT; GGT 1; GGT1; GGT1 protein…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
2365410 Srivastava S, Singh GB, Srivastava SP, Seth PK: Testicular toxicity of di-n-butyl phthalate in adult rats: effect on marker enzymes of spermatogenesis. Indian J Exp Biol. 1990 Jan;28(1):67-70.


The activity of sorbitol dehydrogenase was found to be significantly decreased while that of lactate dehydrogenase, gamma-glutamyl transpeptidase, beta-glucuronidase, and glucose-6-phosphate dehydrogenase, significantly increased in the animals exposed to 500 and 1000 mg/kg of DBP.
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2391408 Fukuoka M, Zhou Y, Tanaka A, Ikemoto I, Machida T: Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. J Appl Toxicol. 1990 Aug;10(4):285-93.


Biochemically, there was elevation of gamma-glutamyl transferase, a decrease in sorbitol levels at 3 h and a decrease in the activity of aldose reductase at 6 h, in the testes of treated rats.
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17214610 Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO: Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):43-8.


While only DBP treatment significantly increased the testicular malondialdehyde level and gamma-glutamyl transferase activity (gamma-GT), it markedly decreased glutathione level, the testicular catalase, glucose-6-phosphate dehydrogenase, superoxide dismutase, sperm gamma-GT activities and serum testosterone level compared to the control group.
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2350234 Srivastava SP, Srivastava S, Saxena DK, Chandra SV, Seth PK: Testicular effects of di-n-butyl phthalate (DBP): biochemical and histopathological alterations. Arch Toxicol. 1990;64(2):148-52.


The activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells, beta-glucuronidase, gamma-glutamyl transpeptidase and glucose-6-phosphate dehydrogenase were significantly increased.
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