Protein Information

Name c Myc
Synonyms MYC; Myc proto oncogene protein; Oncogene MYC; Transcription factor p64; c Myc; v myc avian myelocytomatosis viral oncogene homolog; v myc myelocytomatosis viral oncogene homolog (avian); Myc proto oncogene proteins…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
11857776 Ge R, Tao L, Kramer PM, Cunningham ML, Pereira MA: Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liver. J Biochem Mol Toxicol. 2002;16(1):41-7.

Therefore, the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D), dibutyl phthalate (DBP), gemfibrozil, and Wy-14,643 were evaluated for the ability to alter the methylation and expression of the c-myc protooncogene.
83(1,1,1,3) Details
16137013 Wan WQ, Liu XY, Deng B: [Mechanisms of dibutyl phthalate to purge leukemic cells] . Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Feb;29(1):79-80.

The effects of DBP on the protein expression of c-myc and bcl-2 genes of leukemic cells were measured by immunohistochemical assay.
3(0,0,0,3) Details
16326419 Kang SC, Lee BM: DNA methylation of estrogen receptor alpha gene by phthalates. J Toxicol Environ Health A. 2005 Dec 10;68(23-24):1995-2003.

The phthalates are ubiquitous industrial plasticizers and include agents such as di (2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and butyl benzyl phthalate (BBP), which are classified as endocrine disruptors because of their anti-androgenic or pro-estrogenic effects.
A recent study suggested that DBP produced the hypomethylation of c-myc protooncogene in mouse liver to activate c-myc.
1(0,0,0,1) Details