| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | dibutyl phthalate |
|---|---|
| CAS | dibutyl 1,2-benzenedicarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1488412 | Okita RT, Okita JR: Effects of diethyl and other plasticizers on hydroxylation in rat liver microsomes. Pharm Res. 1992 Dec;9(12):1648-53. In this study, we have compared DEP to four other commonly used plasticizers, 2-diethylhexyl (DEHP), dibutyl phthalate (DBP), 2-diethylhezyl (DEHA), and acetyltributyl (ATBC), for their ability to induce the cytochrome P450-mediated fatty acid omega-hydroxylation system, which is one of the initial cellular responses when animals are treated with peroxisome proliferators. |
31(0,1,1,1) | Details |
| 3099543 | Walseth F, Nilsen OG: esters: effects of orally administered dibutylphthalate on cytochrome P-450 mediated metabolism in rat liver and lung. Acta Pharmacol Toxicol. 1986 Oct;59(4):263-9. |
5(0,0,0,5) | Details |
| 6089701 | Walseth F, Nilsen OG: esters. Arch Toxicol. 1984 Jul;55(2):132-6. Effects of inhaled dibutylphthalate on cytochrome P-450 mediated metabolism in rat liver and lung.. |
3(0,0,0,3) | Details |
| 7115078 | Walseth F, Toftgard R, Nilsen OG: esters I: Effects on cytochrome P-450 mediated metabolism in rat liver and lung, serum enzymatic activities and serum protein levels. Arch Toxicol. 1982 May;50(1):1-10. |
3(0,0,0,3) | Details |
| 6754361 | Seth PK: Hepatic effects of esters. Environ Health Perspect. 1982 Nov;45:27-34. DEHP produced a time- and route-dependent effect on the hepatic cytochrome P-450 contents and activity of aminopyrine N-demethylase, hydroxylase, alcohol dehydrogenase and high and low Km aldehyde dehydrogenases when given orally or intraperitoneally. Activity of aminopyrine N-demethylase and hydroxylase was also inhibited by dimethyl (DMP) and dibutyl phthalate (DBP) after a single oral administration. |
1(0,0,0,1) | Details |
| 18923996 | Ryu JY, Lee E, Kim TH, Lee YJ, Lee J, Lee BM, Kwack SJ, Jung KK, Han SY, Kim SH, Kacew S, Kim HS: Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di (n-butyl) J Toxicol Environ Health A. 2008;71(23):1542-9. The level of cytochrome P-450 (P450) side-chain cleavage (P450scc) mRNA decreased in the group treated with DBP at 750 mg/kg/d at 7 d. |
1(0,0,0,1) | Details |
| 19585553 | Struve MF, Gaido KW, Hensley JB, Lehmann KP, Ross SM, Sochaski MA, Willson GA, Dorman DC: Reproductive toxicity and pharmacokinetics of di-n-butyl (DBP) following dietary exposure of pregnant rats. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):345-54. DBP dietary exposure resulted in significant dose-dependent reductions in testicular mRNA concentration of scavenger receptor class B, member 1; steroidogenic acute regulatory protein; cytochrome P450, family 11, subfamily a, polypeptide 1; and cytochrome P450 family 17, subfamily a, polypeptide 1. |
1(0,0,0,1) | Details |
| 15987825 | Thompson CJ, Ross SM, Hensley J, Liu K, Heinze SC, Young SS, Gaido KW: Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di (n-butyl) Biol Reprod. 2005 Nov;73(5):908-17. Epub 2005 Jun 29. A DBP time-course experiment showed that testicular steroidogenesis was decreased within 1 h of DBP exposure and that this decrease preceded the repressed transcription of Star (steroidogenic acute regulatory protein); Scarb1 (scavenger receptor class B, member 1; also know as Sr-b1); Cyp11a1 (cytochrome P450, family 11, subfamily a, polypeptide 1; also known as P450SCC); and Cyp17a1 (cytochrome P450 family 17, subfamily a, polypeptide 1; also known as Cyp17). |
1(0,0,0,1) | Details |
| 17884934 | Kuhl AJ, Ross SM, Gaido KW: CCAAT/enhancer binding protein beta, but not steroidogenic factor-1, modulates the -induced dysregulation of rat fetal testicular steroidogenesis. Endocrinology. 2007 Dec;148(12):5851-64. Epub 2007 Sep 20. Prolonged in utero exposure of fetal male rats to dibutyl phthalate (DBP) can result in a feminized phenotype characterized by malformed epididymides, hypospadias, cryptorchidism, and retained thoracic nipples, among others. To understand these mechanisms in rats, in vivo DNase footprinting was adapted to provide a semiquantitative map of changes in DNA-protein interactions in the promoter region of steroidogenic genes, including steroidogenic acute regulatory, scavenger receptor B-1, cytochrome P450 side chain cleavage, and cytochrome P450 17A1, that are down-regulated after an in utero DBP exposure. |
1(0,0,0,1) | Details |
| 15141095 | Lehmann KP, Phillips S, Sar M, Foster PM, Gaido KW: Dose-dependent alterations in gene expression and synthesis in the fetal testes of male rats exposed to di (n-butyl) Toxicol Sci. 2004 Sep;81(1):60-8. Epub 2004 May 12. DBP exposure resulted in significant dose-dependent reductions in mRNA and protein concentration of scavenger receptor, steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage, 3beta-hydroxysteroid dehydrogenase, and cytochrome P450c17. |
1(0,0,0,1) | Details |