Protein Information

Name peroxisome proliferator activated receptor gamma
Synonyms HUMPPARG; PAX8/PPARG fusion gene; NR1C3; PPAR gamma; PPAR gamma2; PPARG; PPARG 1; PPARG 2…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
12565198 Kobayashi T, Niimi S, Kawanishi T, Fukuoka M, Hayakawa T: Changes in peroxisome proliferator-activated receptor gamma-regulated gene expression and inhibin/activin-follistatin system gene expression in rat testis after an administration of di-n-butyl phthalate. Toxicol Lett. 2003 Mar 3;138(3):215-25.

3(0,0,0,3) Details
18923996 Ryu JY, Lee E, Kim TH, Lee YJ, Lee J, Lee BM, Kwack SJ, Jung KK, Han SY, Kim SH, Kacew S, Kim HS: Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di (n-butyl) phthalate. J Toxicol Environ Health A. 2008;71(23):1542-9.


DBP significantly increased the peroxisome proliferator-activated receptor-gamma (PPAR-r) and phosphorylated extracellular-signal-regulated kinase (p-ERK1/2) levels in the testis.
1(0,0,0,1) Details
17379376 Ryu JY, Lee BM, Kacew S, Kim HS: Identification of differentially expressed genes in the testis of Sprague-Dawley rats treated with di (n-butyl) phthalate. Toxicology. 2007 May 5;234(1-2):103-12. Epub 2007 Feb 17.


DBP (750 mg/kg/day) significantly increased the TR-alpha1 and PPARgamma expression in testes, whereas the AR and ERbeta protein levels were significantly reduced in the same group.
1(0,0,0,1) Details
18602795 Kusu R, Oishi A, Kakizawa K, Kimura T, Toda C, Hashizume K, Ueda K, Kojima N: Effects of phthalate ester derivatives including oxidized metabolites on coactivator recruiting by PPARalpha and PPARgamma. Toxicol In Vitro. 2008 Sep;22(6):1534-8. Epub 2008 Jun 2.

Other derivatives oxidized at the alkyl group and benzene ring of DEHP, MEHP, dibutyl phthalate and its monoester were also investigated and some affected PPAR activities.
1(0,0,0,1) Details