| Name | P450scc |
|---|---|
| Synonyms | CYP11A; CYP11A1; CYPXIA 1; CYPXIA1; Cholesterol 20 22 desmolase; Cholesterol desmolase; Cholesterol monooxygenase (side chain cleaving); Cholesterol side chain cleavage enzyme… |
| Name | dibutyl phthalate |
|---|---|
| CAS | dibutyl 1,2-benzenedicarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15987825 | Thompson CJ, Ross SM, Hensley J, Liu K, Heinze SC, Young SS, Gaido KW: Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di (n-butyl) Biol Reprod. 2005 Nov;73(5):908-17. Epub 2005 Jun 29. A DBP time-course experiment showed that testicular steroidogenesis was decreased within 1 h of DBP exposure and that this decrease preceded the repressed transcription of Star (steroidogenic acute regulatory protein); Scarb1 (scavenger receptor class B, member 1; also know as Sr-b1); Cyp11a1 (cytochrome P450, family 11, subfamily a, polypeptide 1; also known as P450SCC); and Cyp17a1 (cytochrome P450 family 17, subfamily a, polypeptide 1; also known as Cyp17). |
1(0,0,0,1) | Details |
| 18923996 | Ryu JY, Lee E, Kim TH, Lee YJ, Lee J, Lee BM, Kwack SJ, Jung KK, Han SY, Kim SH, Kacew S, Kim HS: Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di (n-butyl) J Toxicol Environ Health A. 2008;71(23):1542-9. The level of cytochrome P-450 (P450) side-chain cleavage (P450scc) mRNA decreased in the group treated with DBP at 750 mg/kg/d at 7 d. |
2(0,0,0,2) | Details |
| 17379376 | Ryu JY, Lee BM, Kacew S, Kim HS: Identification of differentially expressed genes in the testis of Sprague-Dawley rats treated with di (n-butyl) Toxicology. 2007 May 5;234(1-2):103-12. Epub 2007 Feb 17. In addition, the expression patterns of the steroidogenesis-related genes such as scavenger receptor class B-1 (SR-B1), steroidogenic acute regulated protein (StAR), P450 side chain cleavage (P450scc), CYP17, and CYP19 were further analyzed by RT-PCR. |
2(0,0,0,2) | Details |
| 17379624 | Plummer S, Sharpe RM, Hallmark N, Mahood IK, Elcombe C: Time-dependent and compartment-specific effects of in utero exposure to Di (n-butyl) on gene/protein expression in the fetal rat testis as revealed by transcription profiling and laser capture microdissection. Toxicol Sci. 2007 Jun;97(2):520-32. Epub 2007 Mar 22. At e17.5-19.5, reduced expression of genes involved in uptake/metabolism and steroidogenesis was identified in DBP-exposed animals, including scavenger receptor B1 (SCARB1), HMGCoA synthase, steroidogenic acute regulatory protein, Cyp11a, and Cyp17. |
1(0,0,0,1) | Details |
| 17431488 | Hallmark N, Walker M, McKinnell C, Mahood IK, Scott H, Bayne R, Coutts S, Anderson RA, Greig I, Morris K, Sharpe RM: Effects of monobutyl and di (n-butyl) in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human. Environ Health Perspect. 2007 Mar;115(3):390-6. Epub 2006 Dec 19. RESULTS: Exposure of rats in utero to DBP (500 mg/kg/day) for 48 hr before GD21.5 induced major suppression of intratesticular levels and cytochrome P450 side chain cleavage enzyme (P450scc) expression; this short-term treatment induced LCA, but was less marked than longer term (GD13.5-20.5) DBP treatment. |
1(0,0,0,1) | Details |
| 17400582 | Howdeshell KL, Furr J, Lambright CR, Rider CV, Wilson VS, Gray LE Jr: Cumulative effects of dibutyl phthalate and diethylhexyl on male rat reproductive tract development: altered fetal steroid hormones and genes. Toxicol Sci. 2007 Sep;99(1):190-202. Epub 2007 Mar 30. Fetal T and expression of insl3 and cyp11a were cumulatively decreased by the DBP+DEHP dose. |
1(0,0,0,1) | Details |
| 16458459 | Borch J, Axelstad M, Vinggaard AM, Dalgaard M: Diisobutyl has comparable anti-androgenic effects to di-n-butyl in fetal rat testis. Toxicol Lett. 2006 Jun 1;163(3):183-90. Epub 2006 Feb 2. Additionally, immunohistochemical expression of P450scc and StAR proteins in Leydig cells was reduced by DiBP. |
1(0,0,0,1) | Details |