| Name | alpha 2 adrenoreceptor |
|---|---|
| Synonyms | Alpha 2A Adrenoceptor; ZNF32; ADRA2; ADRA2A; ADRA2R; ADRAR; ALPHA2AAR; Alpha 2A adrenergic receptor… |
| Name | amitraz |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3000030 | Moser VC, MacPhail RC: Yohimbine attenuates the delayed lethality induced in mice by amitraz, a formamidine pesticide. Toxicol Lett. 1985 Nov;28(2-3):99-104. These data suggest that an alpha 2-adrenergic mechanism is involved in the delayed lethality produced by amitraz. |
81(1,1,1,1) | Details |
| 3758001 | Roberts MC, Argenzio A: Effects of amitraz, several opiate derivatives and anticholinergic agents on intestinal in ponies. Equine Vet J. 1986 Jul;18(4):256-60. The results suggest potential clinical applications in horses for in diarrhoea therapy, for alpha 2 adrenergic antagonists in obstruction and ileus and, possibly, of amitraz-like agents in reducing fluid losses in diarrhoea. |
37(0,1,2,2) | Details |
| 15516314 | Lehner AF, Hughes CG, Karpiesiuk W, Harkins JD, Dirikolu L, Bosken J, Camargo F, Boyles J, Troppmann A, Woods WE, Tobin T: Development of a method for the detection and confirmation of the alpha-2 agonist amitraz and its major metabolite in horse urine. J Anal Toxicol. 2004 Oct;28(7):553-62. Amitraz (N'-(2,4-dimethylphenyl)-N-[[(2,4-dimethylphenyl) imino] methyl]-N-methyl-me thanimidamide) is an alpha-2 adrenergic agonist used in veterinary medicine primarily as a scabicide- or acaricide-type insecticide. |
32(0,1,1,2) | Details |
| 15822764 | Gursoy S, Kunt N, Kaygusuz K, Kafali H: Intravenous amitraz poisoning. Clin Toxicol. 2005;43(2):113-6. Amitraz inhibits monoamine oxidase and prostaglandin synthesis and is an alpha-2 adrenergic agonist. |
31(0,1,1,1) | Details |
| 1675967 | Pass MA, Mogg TD: Effect of amitraz and its metabolites on intestinal motility. Comp Biochem Physiol C. 1991;99(1-2):169-72. The results suggest that despite the significant antihistamine activity of amitraz and BTS27271 in vitro, it is probably the alpha-2-adrenergic agonist activity that is the most important in causing large intestinal stasis in vivo. |
31(0,1,1,1) | Details |
| 3012823 | Hsu WH, Lu ZX, Hembrough FB: Effect of amitraz on heart rate and aortic blood pressure in conscious dogs: influence of atropine, prazosin, tolazoline, and yohimbine. Toxicol Appl Pharmacol. 1986 Jun 30;84(2):418-22. Yohimbine, an alpha 2-adrenoreceptor antagonist, given iv at 0.1 mg/kg, prevented hypertension, bradycardia, and sinus arrhythmia induced by amitraz. |
31(0,1,1,1) | Details |
| 2157035 | Cullen LK, Reynoldson JA: Central and peripheral alpha-adrenoceptor actions of amitraz in the dog. J Vet Pharmacol Ther. 1990 Mar;13(1):86-92. |
6(0,0,1,1) | Details |
| 2884938 | Hsu WH, Shaw RN, Schaffer DD, Crump MH, Greer MH: Further evidence to support the alpha 2-adrenergic nature of amitraz-induced decrease in intestinal motility. Arch Int Pharmacodyn Ther. 1987 Mar;286(1):145-51. |
6(0,0,1,1) | Details |
| 2508150 | Gilbert ME, Mack CM: Enhanced susceptibility to kindling by chlordimeform may be mediated by a local anesthetic action. Psychopharmacology. 1989;99(2):163-7. The formamidine pesticides amitraz and chlordimeform have recently been shown to be potent proconvulsants (Gilbert 1988). Two main neuroactive properties have been identified as mediators of formamidine neurotoxicity, alpha-2 adrenergic agonism and local anesthetic actions. |
2(0,0,0,2) | Details |
| 2163971 | Wu D, Costa LG, Murphy SD: [The effect of pesticides-CDM and AMZ on inhibition of the binding of 3H-clonidine to alpha 2-adrenoreceptor in rat forebrain tissue]. Hua Xi Yi Ke Da Xue Xue Bao. 1990 Mar;21(1):17-21. Chlordimeform (CDM) and Amitraz (AMZ) are two formamidine pesticides. |
2(0,0,0,2) | Details |
| 9363478 | Jorens PG, Zandijk E, Belmans L, Schepens PJ, Bossaert LL: An unusual poisoning with the unusual pesticide amitraz. . Hum Exp Toxicol. 1997 Oct;16(10):600-1. We report on a case of human poisoning with amitraz with typical signs of alpha 2-adrenoreceptor stimulation. |
7(0,0,1,2) | Details |
| 3211100 | Gilbert ME: Formamidine pesticides enhance susceptibility to kindled seizures in amygdala and hippocampus of the rat. Neurotoxicol Teratol. 1988 May-Jun;10(3):221-7. Electrical kindling of the amygdala and hippocampus was used to evaluate the effects of two formamidines, chlordimeform (CDF) and amitraz (AMZ), upon seizures susceptibility in the rat. The alpha-2 adrenergic agonist and/or local anesthetic-like properties of these compounds may be responsible for these seizure enhancing effects. |
1(0,0,0,1) | Details |
| 2385843 | Schaffer DD, Hsu WH, Hopper DL: The effects of yohimbine and four other antagonists on amitraz-induced depression of shuttle avoidance responses in dogs. Toxicol Appl Pharmacol. 1990 Jul;104(3):543-7. |
0(0,0,0,0) | Details |
| 6326347 | Hsu WH, Kakuk TJ: Effect of amitraz and chlordimeform on heart rate and pupil diameter in rats: mediated by alpha 2-adrenoreceptors. Toxicol Appl Pharmacol. 1984 May;73(3):411-5. Amitraz-induced mydriasis and bradycardia were blocked by antagonists with alpha 2-adrenoreceptor blocking activity: yohimbine and phentolamine (2.5 mg/kg each, iv). |
112(1,2,2,2) | Details |
| 4075998 | Hsu WH, McNeel SV: Amitraz-induced prolongation of gastrointestinal and bradycardia in dogs and their antagonism by yohimbine: preliminary study. Drug Chem Toxicol. 1985;8(4):239-53. Yohimbine, an alpha 2-adrenergic blocking agent, given IV 20 minutes after amitraz administration, at a dosage of 0.1 mg/kg, reversed both the gastrointestinal and bradycardic effects of amitraz. |
81(1,1,1,1) | Details |
| 11312645 | Altobelli D, Martire M, Maurizi S, Preziosi P: Interaction of formamidine pesticides with the presynaptic alpha (2)-adrenoceptor regulating. Toxicol Appl Pharmacol. 2001 May 1;172(3):179-85. Amitraz also diminished the inhibitory effects of the alpha (2)-adrenergic agonists clonidine and xylazine. |
81(1,1,1,1) | Details |