Protein Information

Name vesicular GABA transporter
Synonyms GABA and glycine transporter; SLC32A1; Solute carrier family 32 member 1; VGAT; VIAAT; Vesicular GABA transporter; Vesicular inhibitory amino acid transporter; bA122O1.1…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
17418495 Fujii M, Arata A, Kanbara-Kume N, Saito K, Yanagawa Y, Obata K: Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter. Neuroscience. 2007 May 25;146(3):1044-52. Epub 2007 Apr 5.

Strychnine reversed inspiratory-phase hyperpolarization to large depolarization in expiratory neurons.
2(0,0,0,2) Details
11487628 Dumoulin A, Triller A, Dieudonne S: IPSC kinetics at identified GABAergic and mixed GABAergic and glycinergic synapses onto cerebellar Golgi cells. J Neurosci. 2001 Aug 15;21(16):6045-57.


Double immunocytochemical stainings demonstrate that GABAergic and glycinergic markers are coexpressed in Lugaro cell axonal varicosities, together with the mixed vesicular inhibitory amino acid transporter.
1(0,0,0,1) Details
12401451 Meier J, Juttner R, Kirischuk S, Grantyn R: Synaptic anchoring of glycine receptors in developing collicular neurons under control of metabotropic glutamate receptor activity. Mol Cell Neurosci. 2002 Oct;21(2):324-40.

Two distinct stages of inhibitory synaptogenesis in cultured collicular neurons were defined on the basis of strychnine sensitivity of IPSCs, presence of EPSCs, KCC2 expression, and transmitter-induced Ca (2+) responses.
In the absence of KCC2 and glutamatergic transmission, newborn VIAAT-labeled boutons contained GlyT2, released glycine, and accumulated postsynaptic gephyrin and GlyRs.
1(0,0,0,1) Details
15555918 Danglot L, Rostaing P, Triller A, Bessis A: Morphologically identified glycinergic synapses in the hippocampus. . Mol Cell Neurosci. 2004 Dec;27(4):394-403.

Inhibitory transmission in the hippocampus is predominantly GABAergic, but electrophysiological data evidenced strychnine-sensitive glycine-induced currents.
Synaptic GlyRs were apposed to glycinergic boutons characterized by the expression of the vesicular and the plasma membrane transporters of glycine (VIAAT and GlyT2, respectively).
1(0,0,0,1) Details
18815261 Rousseau F, Aubrey KR, Supplisson S: The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. J Neurosci. 2008 Sep 24;28(39):9755-68.


At inhibitory synapses, glycine and GABA are accumulated into synaptic vesicles by the same vesicular transporter VGAT/VIAAT (vesicular GABA transporter/vesicular inhibitory amino acid transporter), enabling a continuum of glycine, GABA, and mixed phenotypes.
1(0,0,0,1) Details
15746915 Gillespie DC, Kim G, Kandler K: Inhibitory synapses in the developing auditory system are glutamatergic. Nat Neurosci. 2005 Mar;8(3):332-8. Epub 2005 Jan 30.


Immunohistochemical studies demonstrate synaptic colocalization of the vesicular glutamate transporter 3 with the vesicular GABA transporter, indicating that GABA, glycine and glutamate are released from single MNTB terminals.
1(0,0,0,1) Details