Protein Information

Name glycine receptor beta subunit
Synonyms GLRB; Glycine receptor 58 kDa subunit; Glycine receptor beta; Glycine receptor beta subunit; Glycine receptor subunit beta; Glycine receptor subunit beta precursor; Glycine receptor 58 kDa subunits; Glycine receptor betas…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
8717357 Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR: The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes. Brain Res Mol Brain Res. 1996 Jan;35(1-2):211-9.

Neither [3H] strychnine binding nor glycine-gated currents were detected when the human GlyR beta subunit cDNA was expressed in the human embryonic kidney 293 cell line.
2(0,0,0,2) Details
15928085 Hirata H, Saint-Amant L, Downes GB, Cui WW, Zhou W, Granato M, Kuwada JY: Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8345-50. Epub 2005 May 31.

Similar simultaneous contractions are observed in wild-type embryos treated with strychnine, a blocker of the inhibitory glycine receptor (GlyR).
1(0,0,0,1) Details
8635460 Hartenstein B, Schenkel J, Kuhse J, Besenbeck B, Kling C, Becker CM, Betz H, Weiher H: Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice. EMBO J. 1996 Mar 15;15(6):1275-82.

1(0,0,0,1) Details
18553216 Shen W, Jiang Z, Li B: Glycine input induces the synaptic facilitation in salamander rod photoreceptors. J Biomed Sci. 2008 Nov;15(6):743-54. Epub 2008 Jun 16.


Using specific antibodies against a glycine transporter (GlyT2) and glycine receptor beta subunit, we identified the morphology of glycinergic input in photoreceptor terminals.
1(0,0,0,1) Details
16396929 Balse E, Tessier LH, Forster V, Roux MJ, Sahel JA, Picaud S: Glycine receptors in a population of adult mammalian cones. J Physiol. 2006 Mar 1;571(Pt 2):391-401. Epub 2006 Jan 5.


These glycine-elicited currents were sensitive to strychnine but not to picrotoxin consistent with the expression of alpha-beta-heteromeric glycine receptors.
0(0,0,0,0) Details