| Name | P glycoprotein |
|---|---|
| Synonyms | ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS… |
| Name | abamectin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17134887 | Lespine A, Martin S, Dupuy J, Roulet A, Pineau T, Orlowski S, Alvinerie M: Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. Eur J Pharm Sci. 2007 Jan;30(1):84-94. Epub 2006 Oct 26. In a first approach, the ability of ivermectin (IVM), eprinomectin (EPR), abamectin (ABA), doramectin (DOR), selamectin (SEL), or moxidectin (MOX) to inhibit the rhodamine123 efflux was measured in recombinant cells overexpressing P-gp. |
89(1,1,1,9) | Details |
| 8949985 | Didier A, Loor F: The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor. . Anticancer Drugs. 1996 Sep;7(7):745-51. |
32(0,1,1,2) | Details |
| 9144452 | Lankas GR, Cartwright ME, Umbenhauer D: P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity. Toxicol Appl Pharmacol. 1997 Apr;143(2):357-65. Insensitive CF-1 and CD-1 mice showed abundant levels of P-glycoprotein in these tissues and tolerated doses of abamectin at least 50-fold the minimum toxic dose in the sensitive subgroup. |
9(0,0,1,4) | Details |
| 19879343 | Sun YJ, Long DX, Li W, Hou WY, Wu YJ, Shen JZ: Effects of avermectins on neurite outgrowth in differentiating mouse neuroblastoma N2a cells. Toxicol Lett. 2009 Oct 29. The multidrug resistance transporter, P-glycoprotein (P-gp), is associated with the efflux transport of AVMs and other drugs across the blood-brain and placental barrier, and plays an important role in attenuating the neurotoxicity and developmental toxicity of AVMs. In this study, the mouse neuroblastoma N2a cell line was used to investigate the neurotoxicity of two AVM derivatives: abamectin (ABM) and doramectin (DOR). |
4(0,0,0,4) | Details |