| Name | glutathione S transferases |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | 2,4,5-T |
|---|---|
| CAS | 2-(2,4,5-trichlorophenoxy)acetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6719464 | Vessey DA, Boyer TD: Differential activation and inhibition of different forms of rat liver glutathione S-transferase by the herbicides 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T). Toxicol Appl Pharmacol. 1984 May;73(3):492-9. Glutathione S-transferase form YaYa was maximally inhibited by 72 and 30%, respectively, by 2,4-D and 2,4,5-T. |
194(2,3,3,4) | Details |
| 4060158 | Singh SV, Awasthi YC: Inhibition of human glutathione S-transferases by 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T). Toxicol Appl Pharmacol. 1985 Nov;81(2):328-36. |
31(0,1,1,1) | Details |
| 3358263 | Vessey DA, Boyer TD: Characterization of the activation of rat liver glutathione S-transferases by nonsubstrate ligands. Toxicol Appl Pharmacol. 1988 Apr;93(2):275-80. Pharmacol., 35, 289-295) the activity of glutathione S-transferase form YcYc from rat liver was found to be stimulated by the herbicide 2,4,5-T. |
7(0,0,1,2) | Details |
| 16426233 | Vollrath V, Wielandt AM, Iruretagoyena M, Chianale J: Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem J. 2006 May 1;395(3):599-609. The Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) transcription factor regulates gene expression of the GCLC (glutamate-cysteine ligase catalytic subunit), which is a key enzyme in synthesis, and GSTs (glutathione S-transferases) via the ARE (antioxidant-response element). A similar pattern of co-induction of Mrp2 and GCLC genes was also observed in mouse (Hepa 1-6) and human (HepG2) hepatoma cells treated with BHA, beta-NF (beta-naphthoflavone), 2,4,5-T (trichlorophenoxyacetic acid) or 2AAF (2-acetylaminofluorene), suggesting that these genes share common mechanism (s) of transcriptional activation in response to exposure to xenobiotics. |
1(0,0,0,1) | Details |
| 1494887 | James SI, Ahokas JT: Effect of peroxisome proliferators on -dependent sulphobromophthalein excretion. Xenobiotica. 1992 Dec;22(12):1425-32. The effect of pretreatment of rats with the peroxisome proliferator 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) on sulphobromophthalein excretion from the isolated perfused rat liver has been investigated and compared with the effect of clofibrate which is also a peroxisome proliferator. 2. The results of the present study confirm previous studies that have shown an association between peroxisome proliferation treatment and inhibition of glutathione S-transferase-mediated sulphobromophthalein excretion. |
1(0,0,0,1) | Details |
| 7538273 | Daubaras DL, Hershberger CD, Kitano K, Chakrabarty AM: Sequence analysis of a gene cluster involved in metabolism of 2,4,5-trichlorophenoxyacetic acid by Burkholderia cepacia AC1100. Appl Environ Microbiol. 1995 Apr;61(4):1279-89. Burkholderia cepacia AC1100 utilizes 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) as a sole source of carbon and energy. |
0(0,0,0,0) | Details |