Protein Information

Name P glycoprotein
Synonyms ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS…

Compound Information

Name thiodicarb
CAS

Reference List

PubMed Abstract RScore(About this table)
8644124 Lanning CL, Ayad HM, Abou-Donia MB: P-glycoprotein involvement in cuticular penetration of [14C] thiodicarb in resistant tobacco budworms. Toxicol Lett. 1996 Jun;85(3):127-33.

For these studies, resistant tobacco budworm larvae, expressing four times the P-gp as susceptible larvae, were pretreated with the P-gp inhibitor, quinidine, and challenged topically with thiodicarb.
132(1,2,5,7) Details
8898877 Lanning CL, Fine RL, Corcoran JJ, Ayad HM, Rose RL, Abou-Donia MB: Tobacco budworm P-glycoprotein: biochemical characterization and its involvement in pesticide resistance. Biochim Biophys Acta. 1996 Oct 24;1291(2):155-62.

Inhibition of P-gp decreased the LD50 for thiodicarb by a factor of 12.5.
118(1,2,2,8) Details