Protein Information

Name EGFR
Synonyms EGF receptor; EGFR; EGFR protein; ERBB; ERBB 1; ERBB1; Epidermal growth factor receptor; Epidermal growth factor receptor isoform a variant…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
12732362 Randi AS, Sancovich HA, Ferramola de Sancovich AM, Loaiza A, Kolliker Frers RA, Spinelli F, Kleiman de Pisarev DL: Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver. Biochem Pharmacol. 2003 May 1;65(9):1495-506.

In the present study, the effects of hexachlorobenzene (HCB) on epidermal growth factor receptor (EGFR) content of liver microsomes and plasma membrane, and on EGFR-tyrosine kinase activity in the microsomal fraction were investigated.
39(0,1,2,4) Details
18295415 Randi AS, Sanchez MS, Alvarez L, Cardozo J, Pontillo C, Kleiman de Pisarev DL: Hexachlorobenzene triggers AhR translocation to the nucleus, c-Src activation and EGFR transactivation in rat liver. Toxicol Lett. 2008 Mar 15;177(2):116-22. Epub 2008 Jan 12.
34(0,1,1,4) Details
9570324 Randi AS, Sancovich HA, Ferramola de Sancovich AM, Loaiza A, Krawiec L, Kleiman de Pisarev DL: Hexachlorobenzene-induced alterations of rat hepatic microsomal membrane function. Toxicology. 1998 Feb 6;125(2-3):83-94.

Administration of HCB (100 mg/100 g b.w.) for 10 days caused a 50% reduction in epidermal growth factor receptor (EGF-R) ligand binding.
1(0,0,0,1) Details