| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 577371 | Dybing E, Aune T: Hexachlorobenzene induction of 2,4-diaminoanisole mutagenicity in vitro. Acta Pharmacol Toxicol. 1977 May;40(5):575-83. Hexachlorobenzene (HCB)-pretreatment of rats leads to an increase in liver microsomal 2,4-diaminoanisole activation to a mutagen after a dose of 10 mg/kg intraperitoneally and to an increase in ethylmorphine N-demethylase after a dose of 50 mg/kg intraperitoneally. 2,4-Diaminoanisole mutagenicity was increased 24 hrs after HCB-pretreatment, whereas ethylmorphine N-demethylase first increased after 48 hrs. |
81(1,1,1,1) | Details |
| 2425856 | Gutkina NI, Mishin VM, Liakhovich VV: [Induction of the phenobarbital form of cytochrome P-450 by chemically unrelated compounds]. Biokhimiia. 1986 Jul;51(7):1223-9. The induction of the phenobarbital form of cytochrome P-450 by xenobiotics (phenobarbital, PB, hexachlorobenzene, HCB; hexachlorocyclohexane. It was demonstrated that administration of these compounds to animals is accompanied by an increase in the total cytochrome P-450, -cytochrome P-450 reductase, benzphetamine-N-demethylase and aldrin-epoxidase activities. |
2(0,0,0,2) | Details |
| 6286155 | Goldstein JA, Linko P, Huckins JN, Stalling DL: Structure-activity relationships of chlorinated benzenes as inducers of different forms of cytochrome P-450 in rat liver. Chem Biol Interact. 1982 Aug;41(2):131-9. Hexachlorobenzene (HCB) produced increases in ethoxyresorufin (ERR) O-deethylase, aryl hydrocarbon hydroxylase (AHH) and aminopyrine N-demethylase activities in rat liver phenobarbital which were intermediate between those produced by phenobarbital and 3,4-benzpyrene (BP), alpha-Naphthoflavone (ANF) selectivity inhibited ERR activity in BP and HCB-induced microsomes (94% and 88%). |
31(0,1,1,1) | Details |
| 6640429 | Denomme MA, Leece B, Gyorkos J, Homonko K, Safe S: Polychlorinated and congeners as inducers of rat hepatic drug-metabolizing enzymes in immature male Wistar rats. Can J Physiol Pharmacol. 1983 Sep;61(9):1063-70. Hexachlorobenzene induced N-demethylase and aldrin epoxidase, two PB-inducible enzymes, and benzo [a] pyrene hydroxylase and ethoxyresorufin O-deethylase, two enzymes induced by 3-methylcholanthrene (MC). |
7(0,0,1,2) | Details |
| 3596752 | Li SM, Denomme MA, Leece B, Safe S, Dutton D, Parkinson A, Thomas PE, Ryan D, Bandiera S, Reik LM, et al.: Hexachlorobenzene and substituted pentachlorobenzenes (X-C6Cl5) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases. IARC Sci Publ. 1986;(77):527-34. Hexachlorobenzene (HCB) and 2,3,4,4',5-pentachlorobiphenyl induced a similar spectrum of cytochrome-P-450-dependent mono-oxygenase activities in the rat, including 4-dimethylaminoantipyrine N-demethylase, aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin O-deethylase (EROD). |
7(0,0,1,2) | Details |
| 7126264 | Holme JA, Dybing E: Induction of liver microsomal cytochrome P-450 and associated monooxygenases by octachlorostyrene in inbred strains of mice. Biochem Pharmacol. 1982 Aug 1;31(15):2523-9. Single intraperitoneal injections of octachlorostyrene (OCS) and hexachlorobenzene in genetically polycyclic aromatic hydrocarbon "responsive' C57/BL/6 (B6) mice led to a time- and dose-dependent increase in the levels of liver microsomal cytochromes P-450 and b5 as well as in the activities of cytochrome P-450 (cytochrome c) reductase, ethylmorphine (EM) N-demethylase, 4-nitroanisole (PNA) O-demethylase and acetanilide 4-hydroxylase (AcA hydroxylase). |
7(0,0,1,2) | Details |
| 8154922 | Goerz G, Bolsen K, Kalofoutis A, Tsambaos D: Influence of oral on hepatic and cutaneous P-450-dependent isozyme activities. Arch Dermatol Res. 1994;286(2):104-6. Oral administration of (6 mg/kg per day), 0.05% hexachlorobenzene (HCB) or both drugs simultaneously for 10 days to female Wistar rats caused a statistically significant induction of aminopyrine-N-demethylase (ADM), 7-ethoxyresorufin-O-deethylase (7-ERO-D) and erythromycin-N-demethylase (EMDM) in the liver microsomes. |
6(0,0,1,1) | Details |
| 6620405 | Chu I, Villeneuve D, Secours V, Valli VE: Comparative toxicity of 1,2,3,4-, 1,2,4,5-, and 1,2,3,5-tetrachlorobenzene in the rat: results of acute and subacute studies. J Toxicol Environ Health. 1983 Apr-Jun;11(4-6):663-77. Hepatic microsomal aminopyrine demethylase activity was increased by the administration of this compound at 50 ppm and higher in males and at 500 ppm in the females. |
2(0,0,0,2) | Details |
| 3879174 | Merk H, von Zittwitz A, Bolsen K, Goerz G: Influence of (+)- on the hexachlorobenzene-induced porphyria of rats. Arzneimittelforschung. 1985;35(11):1685-7. The simultaneous treatment of rats with HCB and (+)- decreased the HCB induced cytochrome P-450 content and the aminopyrine-N-demethylase activity. |
2(0,0,0,2) | Details |
| 15808524 | Billi de Catabbi SC, Faletti A, Fuentes F, San Martin de Viale LC, Cochon AC: Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment. Toxicol Appl Pharmacol. 2005 Apr 15;204(2):187-95. HCB treatment induced the accumulation of hepatic porphyrins from day 17 and increased the activities of liver ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and aminopyrine N-demethylase (APND) from day 3 after the last dose. |
1(0,0,0,1) | Details |
| 3085962 | Gutkina NI, Mishin VM: Immunochemical evidences that hexachlorobenzene induces two forms of cytochrome P-450 in the rat liver microsomes. Chem Biol Interact. 1986 Apr;58(1):57-68. Like PB, HCB induces the activities of aminopyrine- and benzphetamine-N-demethylases. |
1(0,0,0,1) | Details |
| 4002661 | Mishin VM, Gutkina NI: [Hexachlorobenzene induction of 2 forms of cytochrome P-450 in the rat liver microsome]. Vopr Med Khim. 1985 Mar-Apr;31(2):68-72. HCB was shown to increase the content of cytochrome P-450 as well as aminopyrine- and benzphetamine-N-demethylase activities in liver microsomes. |
1(0,0,0,1) | Details |
| 3629612 | Cantoni L, Rizzardini M, Tacconi MT, Graziani A: Comparison of hexachlorobenzene-induced alterations of microsomal membrane composition and monooxygenase activity in male and female rats. Toxicology. 1987 Sep;45(3):291-305. Analysis of patterns of induction of microsomal monooxygenases showed that aminopyrine-N-demethylase activity doubled in both sexes after treatment while aryl hydrocarbon hydroxylase activity was 16 times the control value in the females and 1.5 times in the males. |
1(0,0,0,1) | Details |
| 731187 | Mull RL, Winterlin WL, Peoples SA, Giri SN, Ocampo L: Hexachlorobenzene II. J Environ Pathol Toxicol. 1978 Jul-Aug;1(6):927-37. Additionally, hepatic microsomal N-demethylase was increased significantly by the 90-day exposure at 1.0 ppm and the 19-day exposure at 100 ppm, but the hepatic microsomal O-demethylase was significantly increased only after the 1.0-ppm exposure. |
1(0,0,0,1) | Details |
| 6618147 | Campbell MA, Gyorkos J, Leece B, Homonko K, Safe S: The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes. Gen Pharmacol. 1983;14(4):445-54. The effects of 22 organohalogen pesticides as inducers of hepatic drug-metabolizing enzymes in the immature male Wistar rat have been determined, this group includes four isomeric hexachlorocyclohexanes, technical chlordane, alpha-chlordane, gamma-chlordane, oxychlordane, trans-nonachlor, heptachlor, heptachlor epoxide, aldrin, dieldrin, kepone, toxaphene, mirex, hexachlorobenzene (HCB) and several DDT analogs. With the exception of HCB, all of the pesticides induced microsomal dimethylaminoantipyrine, N-demethylase and aldrin epoxidase activities and the cytochrome P-450 content of microsomes from animals pretreated with most of the compounds was also increased compared to control rats. |
1(0,0,0,1) | Details |
| 317704 | Vizethum W, Goerz G: Induction of the hepatic microsomal and nuclear cytochrome P-450 system by hexachlorobenzene, pentachlorophenol and trichlorophenol. Chem Biol Interact. 1979 Dec;28(2-3):291-9. |
0(0,0,0,0) | Details |
| 3952775 | Rozman K, Gorski JR, Rozman P, Parkinson A: Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. Toxicol Lett. 1986 Jan;30(1):71-8. At the end of the experiment (day 97), the concentration of liver microsomal cytochrome P-450 and cytochrome bs and the activity of ethoxyresorufin-O-deethylase, pentoxyresorufin-O-dealkylase, aminopyrine-N-demethylase and UDP-glucuronosyl transferase were significantly induced, whereas the activity of -cytochrome c reductase and benzo [a] pyrene hydroxylase was not. |
1(0,0,0,1) | Details |
| 7979550 | Tsambaos D, Bolsen K, Georgiou S, Monastirli A, Goerz G: Effects of oral thalidomide on rat liver and skin microsomal P450 isozyme activities and on urinary excretion: interaction with oral hexachlorobenzene. Arch Dermatol Res. 1994;286(6):347-9. The protein and P450 contents and the activities of aminopyrine-N-demethylase (ADM) and 7-ethoxyresorufin-O-deethylase (7-ERO-D) were determined in the liver microsomes. |
1(0,0,0,1) | Details |
| 233 | Ivanov E, Krustev L, Adjarov D, Chernev K, Apostolov I, Dimitrov P, Drenska E, Stefanova M, Pramatarova V: Studies on the mechanism of the changes in serum and liver gamma-glutamyl transpeptidase activity. Enzyme. 1976;21(1):8-20. Experimental hexachlorobenzene porphyria in rabbits.. There was a considerable increase in liver microsomal protein, gamma-GT, cytochrome P-450, anilinehydroxylase, aminopyrine-demethylase and synthase. |
1(0,0,0,1) | Details |
| 2510602 | Rodman LE, Shedlofsky SI, Swim AT, Robertson LW: Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture. Arch Biochem Biophys. 1989 Nov 15;275(1):252-62. Dose-response effects for the induction of total cytochrome P450 ethoxyresorufin-O-deethylase (EROD) activity, and benzphetamine demethylase (BPDM) activity were studied using 10 selected tetra- to hexachlorinated PCB congeners. |
1(0,0,0,1) | Details |
| 7466831 | Debets FM, Strik JJ, Olie K: Effects of pentachlorophenol on rat liver changes induced by hexachlorobenzene, with special reference to porphyria, and alterations in mixed function oxygenases. Toxicology. 1980;15(3):181-95. Microsomal cytochrome P-450, -cytochrome c reductase, ethoxyresorufin O-de-ethylase, aminopyrine N-demethylase, and glucuronyl transferase increased to a maximum in 2-4 weeks in HCB and HCB + PCP fed rats. |
1(0,0,0,1) | Details |
| 3872633 | Goerz G, Bolsen K, Merk H: Influence of chloroquine on the metabolism. . Arch Dermatol Res. 1985;277(2):114-7. Rats were treated with the well-known porphyrogen hexachlorobenzene (HCB) to induce experimental porphyria. |
0(0,0,0,0) | Details |
| 7064718 | Holme JA, Dybing E: Induction of liver microsomal cytochrome P-450 and associated monooxygenases by octachlorostyrene in the rat. Acta Pharmacol Toxicol. 1982 Jan;50(1):41-9. The inducing effects of octachlorostyrene (OCS) and hexachlorobenzene (HCB), chlorinated hydrocarbon contaminants found in fish, on the microsomal cytochrome p-450 system were studied in rats. |
0(0,0,0,0) | Details |
| 1265351 | Turner JC, Green RS: The use of a liver biopsy technique for investigating the effects of hexacholrobenzene on some drug-metabolising enzymes in sheep. Res Vet Sci. 1976 Mar;20(2):155-7. Sheep dosed with hexachlorobenzene (hcb) showed increased activities of hydroxylase and 4-nitroanisole O-demethylase but not of the -independent esterases. |
0(0,0,0,0) | Details |
| 7197951 | Goerz G, Bolsen K, Staib AH, Lissner R: [Influence of on hexachlorobenzene induced porphyria (author's transl)]. Arzneimittelforschung. 1981;31(9):1446-7. |
0(0,0,0,0) | Details |