| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | endosulfan |
|---|---|
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3971059 | Narayan S, Bajpai A, Tyagi SR, Misra UK: Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats. Bull Environ Contam Toxicol. 1985 Jan;34(1):55-62. |
6(0,0,1,1) | Details |
| 12564895 | Bargar TA, Scott GI, Cobb GP: Chorioallantoic membranes indicate avian exposure and biomarker responses to environmental contaminants: a laboratory study with White Leghorn chickens (Gallus domesticus). Environ Sci Technol. 2003 Jan 15;37(2):256-60. PCB and endosulfan concentrations in the chorioallantoic membrane (CAM) of white leghorn chickens (Gallus domesticus) were evaluated as indicators of hepatic cytochrome P450 isozyme activity in hens and chicks as well as toxicant concentrations in eggs and hens. |
6(0,0,1,1) | Details |
| 16190021 | Bebe FN, Panemangalore M: Pesticides and essential minerals modify endogenous antioxidants and cytochrome P450 in tissues of rats. J Environ Sci Health B. 2005;40(5):769-84. In both experiments, six rats/group were fed diets based on the AIN-93M diet (Control) or the same modified to contain either 500 mg (Low Ca), 7 mg Zn (Low Zn): 2 mg (Low Cu), 60 mg zinc (High Zn) or 12 mg (High Cu) in the following combination: Control, LCa/LZn, LCa/LZn/LCu, or HZn/HCu, with and without a pesticide mixture containing acephate, endosulfan, and thiram at 25% LD50 for four or two weeks. |
2(0,0,0,2) | Details |
| 15912569 | Espinosa PJ, Contreras J, Quinto V, Gravalos C, Fernandez E, Bielza P: Metabolic mechanisms of insecticide resistance in the western flower thrips, Frankliniella occidentalis (Pergande). Pest Manag Sci. 2005 Oct;61(10):1009-15. The interactions between six insecticides (methiocarb, formetanate, acrinathrin, deltamethrin, methamidophos and endosulfan) and three potential synergists (piperonyl butoxide (PBO), S,S,S-tributyl phosphorotrithioate (DEF) and diethyl (DEM)) were studied by topical exposure in strains selected for resistance to each insecticide, and in a susceptible strain of Frankliniella occidentalis (Pergande). These studies indicate that an enhanced detoxification, mediated by cytochrome P-450 monooxygenases, is the major mechanism imparting resistance to different insecticides in F occidentalis. |
1(0,0,0,1) | Details |
| 2279768 | Singh SK, Pandey RS: Effect of sub-chronic endosulfan exposures on plasma gonadotrophins, testicular and enzymes of androgen biosynthesis in rat. Indian J Exp Biol. 1990 Oct;28(10):953-6. A significant decrease in the contents/activities of microsomal cytochrome P-450 and related mixed function oxidases (MFOs) in testis of treated rats was also observed, along with a marked inhibition in the activity of cytosolic conjugation enzyme, glutathione-S-transferase at both doses studied. |
1(0,0,0,1) | Details |
| 2372869 | Ruch RJ, Fransson R, Flodstrom S, Warngard L, Klaunig JE: Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chlordane and heptachlor. Carcinogenesis. 1990 Jul;11(7):1097-101. |
0(0,0,0,0) | Details |
| 10877774 | Sutherland TD, Horne I, Lacey MJ, Harcourt RL, Russell RJ, Oakeshott JG: Enrichment of an endosulfan-degrading mixed bacterial culture. Appl Environ Microbiol. 2000 Jul;66(7):2822-8. |
0(0,0,0,0) | Details |
| 4093546 | Tyagi SR, Sriram K, Narayan S, Misra UK: Induction of cytochrome P-450 and synthesis by endosulfan in liver of rats: effect of quality of dietary proteins. J Environ Sci Health B. 1985 Dec;20(6):651-64. |
93(1,1,3,3) | Details |
| 16581944 | Lee HK, Moon JK, Chang CH, Choi H, Park HW, Park BS, Lee HS, Hwang EC, Lee YD, Liu KH, Kim JH: Stereoselective metabolism of endosulfan by human liver microsomes and human cytochrome P450 isoforms. Drug Metab Dispos. 2006 Jul;34(7):1090-5. Epub 2006 Mar 31. |
62(0,2,2,2) | Details |
| 6424426 | Sriram K, Misra UK: Interaction of endosulfan and dietary on rat hepatic drug metabolising enzymes. Acta Vitaminol Enzymol. 1983;5(4):213-8. Administration of (10,000 I.U./100 g body weight) daily for ten days reduced the activity of the above mentioned enzymes, when and endosulfan were given together, reduced the endosulfan induced increase of microsomal proteins and cytochrome P-450 levels, the activity of cytochrome C-reductase, aminopyrine N-demethylase and -hydroxylase. |
37(0,1,2,2) | Details |
| 8593059 | Kullman SW, Matsumura F: Metabolic pathways utilized by Phanerochaete chrysosporium for degradation of the cyclodiene pesticide endosulfan. Appl Environ Microbiol. 1996 Feb;62(2):593-600. Piperonyl butoxide, a known cytochrome P-450 inhibitor, significantly inhibited the oxidation of endosulfan to endosulfan and enhanced hydrolysis of endosulfan to endosulfan diol. |
31(0,1,1,1) | Details |
| 16855053 | Casabar RC, Wallace AD, Hodgson E, Rose RL: Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4. Drug Metab Dispos. 2006 Oct;34(10):1779-85. Epub 2006 Jul 19. With the use of recombinant cytochrome P450 (P450) isoforms, we identified CYP2B6 (Km = 16.2 microM, Vmax = 11.4 nmol/nmol P450/min) and CYP3A4 (Km = 14.4 microM, Vmax = 1.3 nmol/nmol P450/min) as the primary enzymes catalyzing the metabolism of endosulfan-alpha, although CYP2B6 had an 8-fold higher intrinsic clearance rate (CL (int) = 0.70 microl/min/pmol P450) than CYP3A4 (CL (int) = 0.09 microl/min/pmol P450). |
31(0,1,1,1) | Details |
| 15649640 | Dehn PF, Allen-Mocherie S, Karek J, Thenappan A: Organochlorine insecticides: impacts on human HepG2 cytochrome P4501A, 2B activities and levels. Toxicol In Vitro. 2005 Mar;19(2):261-73. This study examined the effects of the organochlorine (OC) insecticides chlordane, o,p'-DDT, dieldrin, endosulfan, kepone, methoxychlor, and toxaphene on human HepG2 cytochrome P450 (1A-EROD and 2B-PROD) activities and (GSH) levels. |
6(0,0,1,1) | Details |
| 3680862 | Siddiqui MK, Anjum F, Qadri SS: Some metabolic changes induced by endosulfan in hepatic and extra hepatic tissues of rat. J Environ Sci Health B. 1987 Oct;22(5):553-64. Effects of three different doses of endosulfan respectively designated as low, medium and high on cytochrome P450 (Cyt.P450), glutathione S-transferase (GST) activity and content (GSH) of hepatic and extra hepatic tissues of rat were determined after 24 hours of treatment. |
6(0,0,1,1) | Details |