Protein Information

Name protein is
Synonyms ANX 2; p36; LIP 2; LIP2; ANX2; ANX2L4; ANX2P1; ANX2P2…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
3768018 van Ommen B, Adang AE, Brader L, Posthumus MA, Muller F, van Bladeren PJ: The microsomal metabolism of hexachlorobenzene. Biochem Pharmacol. 1986 Oct 1;35(19):3233-8.

In addition, a considerable amount of covalent binding to protein is detected (250 pmoles pentachlorophenol, 17 pmoles tetrachlorohydroquinone and 11 pmoles covalent binding in an incubation containing 50 mumoles of hexachlorobenzene).
31(0,1,1,1) Details
16679308 Plante I, Charbonneau M, Cyr DG: Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt. Carcinogenesis. 2006 Sep;27(9):1923-9. Epub 2006 May 5.

We have shown that Cx32 is downregulated in the liver of female rats exposed to hexachlorobenzene (HCB), an epigenetic environmental carcinogen.
E-cadherin, an adhering junction protein, is also downregulated in the liver of these female rats, owing to the inactivation of GSK3beta.
1(0,0,0,1) Details