| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7683635 | Tsuda H, Matsumoto K, Ogino H, Ito M, Hirono I, Nagao M, Sato K, Cabral R, Bartsch H: Demonstration of initiation potential of carcinogens by induction of preneoplastic glutathione S-transferase P-form-positive liver cell foci: possible in vivo assay system for environmental carcinogens. Jpn J Cancer Res. 1993 Mar;84(3):230-6. Initiating potential was assayed on the basis of significant increase in values of preneoplastic placental form glutathione S-transferase-positive (GST-P+) foci of more than 3 cells in cross section at week 10. In Experiment 2, group 1 rats were subjected to PH and 12 h later received a suspected carcinogenic mixture of opium pyrolysate (OP) or carcinogenic pesticide p,p'-dichloro-diphenyltrichloroethane or hexachlorobenzene. |
1(0,0,0,1) | Details |
| 19628380 | Said RA, Grassi TF, Scolastici C, Alves de Lima RO, Darros BR, Barbisan LF, de Camargo JL: Absence of chemopreventive influence of propolis on the rat liver altered foci development. Exp Toxicol Pathol. 2009 Jul 21. Male Wistar rats were sequentially initiated with diethylnitrosamine (DEN, 200mg/kgb.w.) and, 2 weeks later, exposed to a diet containing hexachlorobenzene (HCB, 100ppm) and to APE 0.1% through drinking water for 6 weeks. The animals were sacrificed at the weeks 8th and 30th when liver samples were processed to evaluate the development of altered hepatocyte foci (AHF) identified under hematoxylin and eosin (H&E;) staining and by the immunohistochemical expression of the enzyme glutathione S-transferase placental form (GST-P). |
1(0,0,0,1) | Details |
| 17618397 | Elia AC, Dorr AJ, Galarini R: Comparison of organochlorine pesticides, PCBs, and heavy metal contamination and of detoxifying response in tissues of Ameiurus melas from Corbara, Alviano, and Trasimeno Lakes, Italy. Bull Environ Contam Toxicol. 2007 Jun;78(6):463-8. Epub 2007 Jul 7. Accumulation of cadmium (Cd), mercury (Hg), lead (Pb), (Cr), hexachlorobenzene, gamma-HCH, DDTs, and PCBs has been investigated in the muscle of Ameiurus melas sampled during the same period from Lake Corbara, Alviano, and Trasimeno. content and the enzymatic activities of glutathione reductase, peroxidase, catalase, glutathione S-transferase, and glyoxalase I were examined in gills, liver, and kidneys of each specimen. |
1(0,0,0,1) | Details |
| 18098036 | Grassi TF, Tararam CA, Spinardi-Barbisan AL, Domingues MA, de Camargo JL, Barbisan LF: Diuron lacks promoting potential in a rat liver bioassay. Toxicol Pathol. 2007;35(7):897-903. The promoting activity of the herbicide Diuron was evaluated in a medium-term rat liver carcinogenesis bioassay that uses as endpoint immunohistochemically identified glutathione S-transferase positive (GST-P+) foci. |
1(0,0,0,1) | Details |
| 8330354 | Smith AG, Carthew P, Francis JE, Cabral JR, Manson MM: Enhancement by iron of hepatic neoplasia in rats caused by hexachlorobenzene. Carcinogenesis. 1993 Jul;14(7):1381-7. Cytosolic glutathione S-transferase activities were also induced by HCB, but, unlike microsomal EROD, preloading with iron enhanced the effects. |
1(0,0,0,1) | Details |
| 4032490 | Carpenter HM, Williams DE, Buhler DR: Hexachlorobenzene-induced porphyria in Japanese quail: changes in microsomal enzymes. J Toxicol Environ Health. 1985;15(3-4):431-44. Changes included elevation of microsomal protein concentrations and increases in the specific content of cytochrome P-450, in the activities of aryl hydrocarbon hydroxylase (AHH), biphenyl hydroxylase (BPH), ethoxyresorufin-O-deethylase (EROD), and ethoxycoumarin-O-deethylase (ECOD), and in cytosolic and microsomal glutathione S-transferase (GSH-t) levels. |
1(0,0,0,1) | Details |
| 2731154 | Vincent SH, Smith AG, Muller-Eberhard U: Modulation of hepatic heme-binding Z protein in mice by the porphyrogenic carcinogens griseofulvin and hexachlorobenzene. Cancer Lett. 1989 May;45(2):109-14. In contrast, both treatments caused a greater than 4-fold increase in the immunoreactive levels of glutathione S-transferase isozymes (GST) which like HBP also bind heme. |
1(0,0,0,1) | Details |
| 10754204 | Kishima MO, Barbisan LF, Estevao D, Rodrigues MA, Viana de Camargo JL: Promotion of hepatocarcinogenesis by hexachlorobenzene in energy-restricted rats. Cancer Lett. 2000 Apr 28;152(1):37-44. |
0(0,0,0,0) | Details |
| 12038708 | Iscan M, Coban T, Cok I, Bulbul D, Eke BC, Burgaz S: The organochlorine pesticide residues and antioxidant enzyme activities in human breast tumors: is there any association?. Breast Cancer Res Treat. 2002 Mar;72(2):173-82. The levels of some organochlorine pesticides (OCP) s (hexachlorobenzene, HCB, alpha-hexachlorocyclohexane, alpha-HCH, beta-HCH, gamma-HCH, heptachlorepoxide, HE, bis (4-chlorophenyl)-1,1-dichloroethene, p.p'DDE, bis (4-chlorophenyl)-1,1,1-trichloroethane, p.p' DDT and total DDT (E-DDT) and antioxidant enzyme activities namely Cu, Zn superoxide dismutase (SOD), catalase (CAT), -dependent peroxidase (Se--Px), total peroxidase (T--Px), independent peroxidase -Px II), glutathione reductase (GRd), level of and lipid peroxidation (LP), glutathione S-transferase (GST) activity toward several substrates including 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), ethacrynic acid (EAA), 1,2-epoxy-3-(p-nitrophenoxy)-propane (ENPP) were measured in tumor and surrounding tumor free tissues of 24 female breast cancer patients and was evaluated whether there exist any association between the levels of OCPs and antioxidants. |
31(0,1,1,1) | Details |
| 3355583 | Vos RM, Snoek MC, van Berkel WJ, Muller F, van Bladeren PJ: Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Biochem Pharmacol. 1988 Mar 15;37(6):1077-82. |
13(0,0,2,3) | Details |
| 6636202 | Miranda CL, Wang JL, Henderson MC, Carpenter HM, Nakaue HS, Buhler DR: Studies on the porphyrinogenic action of 1,2,4-trichlorobenzene in birds. Toxicology. 1983 Sep;28(1-2):83-92. Liver and glutathione S-transferase activity were also significantly increased following repeated administration of TCB in quail, which could indicate an enhancement of detoxication of reactive metabolites of TCB. |
2(0,0,0,2) | Details |
| 19954812 | Faria M, Huertas D, Soto DX, Grimalt JO, Catalan J, Riva MC, Barata C: Contaminant accumulation and multi-biomarker responses in field collected zebra mussels (Dreissena polymorpha) and crayfish (Procambarus clarkii), to evaluate toxicological effects of industrial hazardous dumps in the Ebro river (NE Spain). Chemosphere. 2010 Jan;78(3):232-40. Epub 2009 Dec 1. Biological responses included levels of metallothioneins, activities of ethoxyresorufin-O-deethylase, oxidative stress biomarkers content, enzymatic activities of superoxide dismutase, catalase, glutathione s-transferase, peroxidise and glutathione reductase), levels of lipid peroxidation and of DNA strand breaks. The aforementioned stress levels could be related with concentrations of mercury, cadmium, hexachlorobenzene, polychlorobiphenyls and dichlorodiphenyltrichloroethanes from 4- to 195-fold greater than local background levels. |
1(0,0,0,1) | Details |
| 12297372 | Ruus A, Sandvik M, Ugland KI, Skaare JU: Factors influencing activities of biotransformation enzymes, concentrations and compositional patterns of organochlorine contaminants in members of a marine food web. Aquat Toxicol. 2002 Nov 13;61(1-2):73-87. The accumulation of polychlorinated biphenyls (PCBs; 34 congeners), sigmaDDT (p,p'-DDT, o,p'-DDT, p,p'-DDD, o,p'-DDD and p,p'-DDE), chlordanes (sigmaCHL; trans-chlordane, cis-chlordane, trans-nonachlor, cis-nonachlor and oxychlordane), hexachlorocyclohexanes (sigmaHCH; alpha-, beta- and gamma-isomers), hexachlorobenzene (HCB) and mirex was investigated in members of a marine food web from the Hvaler and Torbjornskaer archipelago, south-eastern Norway. Furthermore, hepatic biotransformation enzyme activities (ethoxyresorufin-O-deethylase (EROD), pentoxyresorufin-O-depentylase (PROD) and glutathione S-transferase (GST)) were measured in all species. |
1(0,0,0,1) | Details |
| 3981666 | Carpenter HM, Williams DE, Buhler DR: A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail. J Toxicol Environ Health. 1985;15(1):93-108. Additional similarities between HCB- and BNF-treated quail included a comparable hypsochromic absorption shift in the CO-reduced difference spectra of cytochrome P-450 and similar effects on the activities of cytosolic glutathione S-transferase (GSH-t), biphenyl hydroxylase (BPH), and ethoxyresorufin O-deethylase (EROD). |
1(0,0,0,1) | Details |