| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | mirex |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 35323 | Mehendale HM, Ho IK, Desaiah D: Possible molecular mechanism of mirex-induced hepatobiliary dysfunction. Drug Metab Dispos. 1979 Jan-Feb;7(1):28-33. Whereas mitochondrial Mg++-ATPase and microsomal Na+-K+-ATPase activities were both inhibited by exposure to mirex in a dose-dependent manner, the latter activity was consistently inhibited to a higher degree. |
31(0,1,1,1) | Details |
| 6160190 | Desaiah D: Comparative effects of chlordecone and mirex on rat cardiac ATPases and binding of 3H-catecholamines. J Environ Pathol Toxicol. 1980 Aug;4(1):237-48. However, mirex treated rats showed a slight decrease in the myocardial Na+--K+ ATPase. |
9(0,0,1,4) | Details |
| 66775 | Desaiah D, Ho IK, Mehendale HM: Effects of kepone and mirex on mitochondrial Mg2+-ATPase activity in rat liver. Toxicol Appl Pharmacol. 1977 Feb;39(2):219-28. |
6(0,0,1,1) | Details |
| 6175765 | Desaiah D: Interaction of chlordecone with biological membranes. . J Toxicol Environ Health. 1981 Nov-Dec;8(5-6):719-30. Chlordecone (Kepone) is a close structural analog of mirex, but it differs considerably from mirex in toxic action. The order of sensitivity of the ATPases tested to chlordecone was: oligomycin-sensitive (mitochondrial) Mg2+-ATPase greater than Na+,K+-ATPase greater than Ca2+-ATPase greater than oligomycin-insensitive Mg2+-ATPase. |
3(0,0,0,3) | Details |
| 1696822 | Kodavanti PR, Kodavanti UP, Mehendale HM: Altered hepatic energy status in chlordecone (Kepone)-potentiated CCl4 hepatotoxicity. Biochem Pharmacol. 1990 Aug 15;40(4):859-66. Oligomycin-sensitive Mg2 (+)-ATPase was decreased significantly only starting at 6 hr (21%) after CCl4 administration, indicating that depletion of ATP at early time points was most likely due to rapid utilization consequent to toxic events. CCl4 administration to mirex or PB pretreated rats resulted in a smaller decrease in ATP levels (18-24%) only at 24 hr, returning to normal levels by 36-48 hr, in accord with rapid recovery from limited liver injury. |
2(0,0,0,2) | Details |
| 6188962 | Shankland DL: action of chlorinated hydrocarbon insecticides. Neurobehav Toxicol Teratol. 1982 Nov-Dec;4(6):805-11. These actions may be functionally related to inhibition of an ecto Ca2+ ATPase, but at this time there is insufficient evidence to draw that conclusion. Bicyclodienes, lindane and mirex and certain of its analogs act at presynaptic terminals to enhance the release of neurotransmitter. |
2(0,0,0,2) | Details |
| 4279111 | Koch RB, Desaiah D: Inhibition of Escherichia coli Mg2+ ATPase. Biochim Biophys Acta. 1974 Oct 29;367(2):259-63. Synergism between a fire ant, Solenopsis richteri (Forel) abdomen factor and a photoreduction product of Mirex. |
1(0,0,0,1) | Details |
| 1696754 | Teo S, Vore M: Mirex exposure inhibits the uptake of -17 beta (beta-D- taurocholate, and into isolated rat hepatocytes. Toxicol Appl Pharmacol. 1990 Jul;104(3):411-20. |
0(0,0,0,0) | Details |