| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | mirex |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6200121 | Ebel RE: Hepatic microsomal p-nitroanisole O-demethylase. Biochem Pharmacol. 1984 Feb 15;33(4):559-64. The effects of chlordecone (CD) or mirex treatment on the hepatic microsomal monooxygenase system of male and female rats were investigated, and kinetic parameters (apparent Vmax and apparent Km) for p-nitroanisole O-demethylase were studied in detail. |
7(0,0,1,2) | Details |
| 3738931 | Yarbrough JD, Grimley JM, Alley EG: Induction of the hepatic cytochrome P-450 dependent monooxygenase system by cis- and trans-5,10-dihydrogen mirex. Toxicol Lett. 1986 Jul-Aug;32(1-2):65-71. In contrast, aminopyrine N-demethylase was significantly increased by the cis-isomer in both sexes. |
2(0,0,0,2) | Details |
| 3113478 | Thomas PE, Bandiera S, Maines SL, Ryan DE, Levin W: Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes. Biochemistry. 1987 Apr 21;26(8):2280-9. Several xenobiotics, such as Aroclor 1254, mirex, and 3-methylcholanthrene, repressed cytochrome P-450j levels when administered to male rats. |
2(0,0,0,2) | Details |
| 9456078 | Khan MA, Jovanovich LV, Martin LT, Qadri SY, Podowski AA: Effects of photoisomers of cyclodiene insecticides on liver and microsomal cytochrome P450 in rats. Arch Toxicol. 1998;72(2):74-83. Maximum increase in total P450 concentration (30%) and demethylases activities (100%) was always respectively one-third or one-tenth of that reported for parent cyclodienes. However, higher dosages of photoisomers caused wasting and lowered both the liver weight and the activity of hydroxylase while those of mirex and endrin, which also caused wasting and lowered hydroxylase activity, continued causing further hepatic hypertrophy. |
1(0,0,0,1) | Details |
| 7817119 | Thakore KN, Mehendale HM: Effect of phenobarbital and mirex pretreatments on CCl4 autoprotection. Toxicol Pathol. 1994 May-Jun;22(3):291-9. In a second experiment, in rats maintained on N, PB, or M diet, liver microsomal cytochromes P-450, aminopyrine demethylase, and hydroxylase were measured at various time points after the administration of the protective dose of CCl4. |
1(0,0,0,1) | Details |
| 2481745 | Lewandowski M, Levi P, Hodgson E: Induction of cytochrome P-450 isozymes by mirex and chlordecone. J Biochem Toxicol. 1989 Fall;4(3):195-9. Benzphetamine N-demethylase, ethoxyresorufin O-deethylase, benzo [a] pyrene hydroxylase, and acetanilide hydroxylase activities were also determined. |
1(0,0,0,1) | Details |
| 6188242 | Chambers JE, Trevathan CA: Effect of mirex, dechlorinated mirex derivatives and chlordecone on microsomal mixed-function oxidase activity and other hepatic parameters. Toxicol Lett. 1983 Apr;16(1-2):109-15. All compounds except chlordecone increased relative liver weight and the activities of aminopyrine N-demethylase and p-nitroanisole O-demethylase. |
1(0,0,0,1) | Details |
| 6618147 | Campbell MA, Gyorkos J, Leece B, Homonko K, Safe S: The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes. Gen Pharmacol. 1983;14(4):445-54. The effects of 22 organohalogen pesticides as inducers of hepatic drug-metabolizing enzymes in the immature male Wistar rat have been determined, this group includes four isomeric hexachlorocyclohexanes, technical chlordane, alpha-chlordane, gamma-chlordane, oxychlordane, trans-nonachlor, heptachlor, heptachlor epoxide, aldrin, dieldrin, kepone, toxaphene, mirex, hexachlorobenzene (HCB) and several DDT analogs. With the exception of HCB, all of the pesticides induced microsomal dimethylaminoantipyrine, N-demethylase and aldrin epoxidase activities and the cytochrome P-450 content of microsomes from animals pretreated with most of the compounds was also increased compared to control rats. |
1(0,0,0,1) | Details |
| 6838646 | Bulger WH, Kupfer D: Effect of xenobiotic estrogens and structurally related compounds on 2-hydroxylation of and on other monooxygenase activities in rat liver. Biochem Pharmacol. 1983 Mar 15;32(6):1005-10. Treatment of ovariectomized (ovex) rats with o,p'DDT or p,p'DDE caused induction of hepatic -2-hydroxylation and increased demethylase activities of several substrates. Administration of Kepone (estrogenic) and Mirex (nonestrogenic), both inducers of hepatic monooxygenase, also increased 2-hydroxylation of |
1(0,0,0,1) | Details |