| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | monuron |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16661486 | Reichhart D, Salaun JP, Benveniste I, Durst F: Time Course of Induction of Cytochrome P-450, -Cytochrome c Reductase, and Hydroxylase by Phenobarbital, Herbicides, and in Higher Plant Microsomes. Plant Physiol. 1980 Oct;66(4):600-604. The mixed function oxidase 4-hydroxylase, cytochrome P-450, cytochrome b (5), and -cytochrome c (P-450) reductase were measured in microsomes from aging artichoke tuber slices exposed to phenobarbital, and the herbicides Chloro-IPC, Dichlobenil, and Monuron. |
33(0,1,1,3) | Details |
| 11940454 | Elcombe CR, Odum J, Foster JR, Stone S, Hasmall S, Soames AR, Kimber I, Ashby J: Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens. Environ Health Perspect. 2002 Apr;110(4):363-75. We administered the chemicals (diethylhexyl cinnamyl chlorendic acid, 1,4-dichlorobenzene, monuron, ethylene thiourea, diethyl thiourea, trimethyl thiourea, and to the same strains of mice and rats used in the original NTP bioassays (nine chemicals to rats and seven to mice). We studied relative weight, cell labeling indices, and pathologic changes such as hypertrophy in all tissues; a range of cytochrome P450 enzymes and palmitoyl coenzyme A oxidase in the liver; changes in the levels of plasma total total and thyroid-stimulating hormone (TSH) as markers of thyroid gland function; and hyaline droplet formation, tubular basophilia, and the formation of granular casts in the kidney. |
1(0,0,0,1) | Details |
| 7903485 | Kitchin KT, Brown JL, Kulkarni AP: Predicting rodent carcinogenicity of halogenated hydrocarbons by in vivo biochemical parameters. Teratog Carcinog Mutagen. 1993;13(4):167-84. The effects of these 40 chemicals on four biochemical assays [hepatic DNA damage by alkaline elution (DD), hepatic ornithine decarboxylase activity (ODC), serum alanine aminotransferase activity (ALT), and hepatic cytochrome P-450 content (P450)] were determined. For predicting the carcinogenicity of the most difficult halogenated hydrocarbons (Ames and SA negative chemicals), TS was capable of successfully predicting the carcinogenicity of 8 (carbon tetrachloride, chloroform, alpha-hexachlorocyclohexane, kepone, mirex, monuron, p,p'-DDE, and 2,4,6-trichlorophenol) out of 16 of these non-DNA-reactive halogenated hydrocarbon carcinogens. |
1(0,0,0,1) | Details |