| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | myclobutanil |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19010342 | Chen PJ, Padgett WT, Moore T, Winnik W, Lambert GR, Thai SF, Hester SD, Nesnow S: Three conazoles increase hepatic microsomal metabolism and decrease mouse hepatic levels in vivo. Toxicol Appl Pharmacol. 2009 Jan 15;234(2):143-55. Epub 2008 Oct 29. The goals of this study were to examine effects of propiconazole, triadimefon, and myclobutanil, three triazole-containing conazoles, on the microsomal metabolism of atRA, the associated hepatic cytochrome P450 (P450) enzyme (s) involved in atRA metabolism, and their effects on hepatic atRA levels in vivo. |
31(0,1,1,1) | Details |
| 16971344 | Barton HA, Tang J, Sey YM, Stanko JP, Murrell RN, Rockett JC, Dix DJ: Metabolism of myclobutanil and triadimefon by human and rat cytochrome P450 enzymes and liver microsomes. Xenobiotica. 2006 Sep;36(9):793-806. |
31(0,1,1,1) | Details |
| 19938956 | Goetz AK, Rockett JC, Ren H, Thillainadarajah I, Dix DJ: Inhibition of rat and human steroidogenesis by triazole antifungals. Syst Biol Reprod Med. 2009 Dec;55(5-6):214-26. Three agricultural antifungal triazoles that are known to modulate expression of cytochrome P450 (CYP) genes and enzymatic activities were tested for effects on steroidogenesis using rat in vivo (triadimefon), rat in vitro (myclobutanil and triadimefon), and human in vitro (myclobutanil, propiconazole, and triadimefon) model systems. |
31(0,1,1,1) | Details |
| 17484520 | Sun G, Grindstaff RD, Thai SF, Lambert GR, Tully DB, Dix DJ, Nesnow S: Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon. Xenobiotica. 2007 Feb;37(2):180-93. |
12(0,0,2,2) | Details |
| 17178687 | Allen JW, Wolf DC, George MH, Hester SD, Sun G, Thai SF, Delker DA, Moore T, Jones C, Nelson G, Roop BC, Leavitt S, Winkfield E, Ward WO, Nesnow S: Toxicity profiles in mice treated with hepatotumorigenic and non-hepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil. Toxicol Pathol. 2006;34(7):853-62. As a component of a large-scale study aimed at determining the mode (s) of action for tumorigenic conazoles, we report the results from comparative evaluations of liver and body weights, liver histopathology, cell proliferation, cytochrome P450 (CYP) activity, and serum high-density lipoprotein and triglyceride levels after exposure to propiconazole, triadimefon, and myclobutanil. |
6(0,0,1,1) | Details |
| 18944284 | Schnabel G, Jones AL: The 14alpha-Demethylasse (CYP51A1) Gene is Overexpressed in Venturia inaequalis Strains Resistant to Myclobutanil. Phytopathology. 2001 Jan;91(1):102-10. ABSTRACT We identified the cytochrome P450 sterol 14alpha-demethylase (CYP51A1) gene from Venturia inaequalis and optional insertions located upstream from CYP51A1 and evaluated their potential role in conferring resistance to the sterol demethylation-inhibitor (DMI) fungicide my-clobutanil. |
1(0,0,0,1) | Details |
| 16643972 | Tully DB, Bao W, Goetz AK, Blystone CR, Ren H, Schmid JE, Strader LF, Wood CR, Best DS, Narotsky MG, Wolf DC, Rockett JC, Dix DJ: Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides. Toxicol Appl Pharmacol. 2006 Sep 15;215(3):260-73. Epub 2006 Apr 27. Adult male Sprague-Dawley rats were dosed for 14 days by gavage with fluconazole, myclobutanil, propiconazole, or triadimefon. Triazole fungicides are designed to inhibit fungal cytochrome P450 (CYP) 51 enzyme but can also modulate the expression and function of mammalian CYP genes and enzymes. |
1(0,0,0,1) | Details |
| 16730040 | Goetz AK, Bao W, Ren H, Schmid JE, Tully DB, Wood C, Rockett JC, Narotsky MG, Sun G, Lambert GR, Thai SF, Wolf DC, Nesnow S, Dix DJ: Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides. Toxicol Appl Pharmacol. 2006 Sep 15;215(3):274-84. Epub 2006 May 26. Besides organ weight, histopathology, and cytochrome P450 (CYP) enzyme induction, DNA microarrays were used to generate gene expression profiles and hypotheses on potential mechanisms of action for this class of chemicals. Adult male CD-1 mice were exposed daily for 14 days to fluconazole, myclobutanil, propiconazole, or triadimefon at three dose levels by oral gavage. |
1(0,0,0,1) | Details |