| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | zineb |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 4082194 | Borin C, Periquet A, Mitjavila S: Studies on the mechanism of nabam- and zineb-induced inhibition of the hepatic microsomal monooxygenases of the male rat. Toxicol Appl Pharmacol. 1985 Dec;81(3 Pt 1):460-8. Incubation of nabam and zineb with hepatic microsomes, without leads to an inhibition of the metabolism of aminopyrine and and to a denaturation of cytochrome P-450 into cytochrome P-420; in addition nabam causes the destruction of cytochrome P-450. |
113(1,2,2,3) | Details |
| 9311082 | Nebbia C, Dacasto M, Topi B, Burdino E, Ugazio G: ethylene-bis-dithiocarbamate (Zineb)-mediated inhibition of monooxygenases and lipid peroxidation in bovine liver microsomes. Vet Hum Toxicol. 1997 Oct;39(5):272-5. It is concluded that Zineb can depress monooxygenase activity in bovine hepatic microsomes mainly through the denaturation of cytochrome P450 and the impaired transfer of reducing equivalents to the complex cytochrome P450-substrate. |
83(1,1,1,3) | Details |
| 8295852 | Nebbia C, Dacasto M, Soffietti MG, Rasero R, Principato GB, Di Simplicio P: Inhibition of hepatic xenobiotic metabolism and of -dependent enzyme activities by zinc ethylene-bis-dithiocarbamate in the rabbit. Pharmacol Toxicol. 1993 Oct;73(4):233-9. While a pronounced reduction in the rate of oxidative biotransformations occurred after either single or repeated exposure, both cytochrome P450 and total haem content were lowered following acute challenge to zineb. |
31(0,1,1,1) | Details |
| 9037261 | Della Croce C, Morichetti E, Intorre L, Soldani G, Bertini S, Bronzetti G: Biochemical and genetic interactions of two commercial pesticides with the monooxygenase system and chlorophyllin. J Environ Pathol Toxicol Oncol. 1996;15(1):21-8. Two commercial preparations of atrazine and zineb were tested on a diploid D7 strain of the yeast Saccharomyces cerevisiae using cells from logarithmic growth phase (with a high level of cytochrome P-450) and from stationary growth phase. |
7(0,0,1,2) | Details |
| 8434452 | Siddiqui A, Ali B, Srivastava SP: Age-related effects in the inhibition of oxidative metabolism of xenobiotics by mancozeb. Vet Hum Toxicol. 1993 Feb;35(1):4-6. There was a concentration-dependent decrease in cytochrome P-450 and microsomal protein contents. |
1(0,0,0,1) | Details |