Protein Information

Name demethylase
Synonyms DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases…

Compound Information

Name zineb
CAS

Reference List

PubMed Abstract RScore(About this table)
174473 Albrecht R, Pelissier MA, Manchon P, Dupuis D: [Effect of methyl parathion and zineb administration on the activity of some hepatic enzymes in rats]. Ann Nutr Aliment. 1975;29(3):223-38.

The activity of hepatic microsomal enzymes, namely :aminopyrine N-demethylase, BHT oxidase, aniline hydroxylase, Butter Yellow & Amaranth reductases, NADPH-cyt. c reductase, G6P phosphatase, were measured.
1(0,0,0,1) Details
9311082 Nebbia C, Dacasto M, Topi B, Burdino E, Ugazio G: Zinc ethylene-bis-dithiocarbamate (Zineb)-mediated inhibition of monooxygenases and lipid peroxidation in bovine liver microsomes. Vet Hum Toxicol. 1997 Oct;39(5):272-5.

Only the higher concentrations of the fungicide (2.5 and 0.25 mM) elicited a sharp decline in cytochrome P450, cytochrome b5 and total sulphydryl groups content as well as in the activities of NADPH cytochrome c reductase, aminopyrine N-demethylase and aniline 4-hydroxylase.
1(0,0,0,1) Details
1946188 Siddiqui A, Ali B, Srivastava SP: Heterogeneous effects of ethylenebisdithiocarbamate (EBDC) pesticides on oxidative metabolism of xenobiotics. Pharmacol Toxicol. 1991 Jul;69(1):13-6.

Mancozeb inhibited p-nitroanisole O-dealkylase and aniline hydroxylase to a greater degree than zineb, whereas the inhibition of aminopyrine N-demethylase by the two fungicides was quantitatively comparable.
82(1,1,1,2) Details
8434452 Siddiqui A, Ali B, Srivastava SP: Age-related effects in the inhibition of oxidative metabolism of xenobiotics by mancozeb. Vet Hum Toxicol. 1993 Feb;35(1):4-6.


Mancozeb caused a dose-dependent inhibition in the activities of p-nitroanisole O-dealkylase and aniline hydroxylase, while the activities of aminopyrine N-demethylase and benzo (a) pyrene hydroxylase were unaffected in all the age groups.
1(0,0,0,1) Details
1015739 Pelissier MA, Atteba S, Manchon P, Albrecht R: [Diminution of activity of liver microsomal oxygenase in a rat fed with a diet with added zineb]. Ann Nutr Aliment. 1976;30(1):45-54.

The microsomes are then used for measuring the activity of both aminophenazone demethylase and aniline hydroxylase as well as the liver concentration of cyt.
1(0,0,0,1) Details